Patents by Inventor Seetharamaiyer Padmanabhan

Seetharamaiyer Padmanabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS
    Publication number: 20140323554
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: February 21, 2014
    Publication date: October 30, 2014
    Applicant: SPRING BANK PHARMACEUTICALS, INC.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Nucleotide and oligonucleotide prodrugs
    Patent number: 8691787
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: April 8, 2014
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • METHODS AND PROCESSES FOR ATTACHING COMPOUNDS TO MATRICES
    Publication number: 20130078390
    Abstract: The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 28, 2013
    Applicant: Spring Bank Pharmaceuticals, Inc.
    Inventors: Seetharamaiyer Padmanabhan, Radhakrishnan P. Iyer
  • Compositions and methods for treating viral infections
    Patent number: 8404651
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: March 26, 2013
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS
    Publication number: 20120264709
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: November 14, 2011
    Publication date: October 18, 2012
    Applicant: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Methods and processes for attaching compounds to matrices
    Patent number: 8287700
    Abstract: The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: October 16, 2012
    Assignee: Spring Bank
    Inventors: Seetharamaiyer Padmanabhan, Radhakrishnan P. Iyer
  • Nucleotide and oligonucleotide prodrugs
    Patent number: 8076303
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: December 13, 2011
    Assignee: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20110207690
    Abstract: The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
    Type: Application
    Filed: October 4, 2010
    Publication date: August 25, 2011
    Applicant: Spring Bank Pharmaceuticals, Inc.
    Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
  • Methods and Processes for Attaching Compounds to Matrices
    Publication number: 20100096251
    Abstract: The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 22, 2010
    Inventors: Seetharamaiyer Padmanabhan, Radhakrishnan P. Iyer
  • Nucleotide and oligonucleotide prodrugs
    Publication number: 20070149462
    Abstract: The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 28, 2007
    Inventors: Radhakrishnan Iyer, Seetharamaiyer Padmanabhan
  • Pharmaceutically active compounds and methods of use
    Publication number: 20060270741
    Abstract: The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
    Type: Application
    Filed: March 17, 2006
    Publication date: November 30, 2006
    Applicant: Scion Pharmaceuticals, Inc.
    Inventors: Graham Durant, Seetharamaiyer Padmanabhan
  • Pharmaceutically active compounds and methods of use
    Patent number: 7041702
    Abstract: The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 9, 2006
    Assignee: Scion Pharmaceuticals, Inc.
    Inventors: Graham J. Durant, Seetharamaiyer Padmanabhan
  • Reactor for chemical synthesis
    Publication number: 20060014176
    Abstract: The present invention relates to the design and use of a multipurpose reactor that may be adapted to accommodate a wide variety of solid phase and liquid phase reaction chemistries.
    Type: Application
    Filed: May 25, 2005
    Publication date: January 19, 2006
    Inventors: Radhakrishnan Iyer, Seetharamaiyer Padmanabhan, John Coughlin
  • Methods and processes for attaching compounds to matrices
    Publication number: 20050239112
    Abstract: The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.
    Type: Application
    Filed: March 31, 2005
    Publication date: October 27, 2005
    Applicant: Migenix, Inc.
    Inventors: Seetharamaiyer Padmanabhan, Radhakrishnan Iyer
  • Pharmaceutically active compound and methods of use
    Patent number: 6774263
    Abstract: This invention relates to racemic and optically active N-(2-chloro-5-methylthiophenyl)-N′-(3-methylsulfinylphenyl)-N′-methylguanidine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, and N-(3-methylsulfinylphenyl)-N-methyl-N′-(2-chloro-5-methoxyphenyl)guanidine and pharmaceutically acceptable salts thereof, and pharmaceutical compositions and therapeutic methods of treatment that comprise such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: August 10, 2004
    Assignee: Cambridge Neuroscience, Inc.
    Inventors: Graham J. Durant, Michael Perlman, James B. Fischer, Seetharamaiyer Padmanabhan