Abstract: The present invention relates to an electroceutical system for driving a photoelectric element implanted in a sub-retinal optic nerve using a smart photonic lens. According to the present invention, by artificially emitting the light of the smart photonic lens to a photoelectric element connected to the optic nerve, it is possible to utilize stimulation of the nerve with an electric current generated in the photoelectric element to treat various diseases.

Abstract: The present invention relates to a wireless theranostic contact lens, which includes gold hollow nanowires having excellent safety and stability in vivo and excellent sensitivity and a controlled drug delivery system allowed to contain a high content of a drug for treating glaucoma. The contact lens of the present invention is allowed to monitor intraocular pressure in real time and release an appropriate drug from the controlled drug delivery system according to a state of the intraocular pressure, thereby enabling personalized intraocular pressure adjustment.

Abstract: The present invention provides a wirelessly driven contact lens including a strain sensor capable of detecting an increase in intraocular pressure in real time and a drug reservoir capable of lowering the intraocular pressure by releasing a drug based on the increase in intraocular pressure. In the present invention, there may be provided a personal therapy system that measures intraocular pressure in real time and properly releases a therapeutic drug according to the intraocular pressure that is measured through the strain sensor and the drug reservoir for releasing a drug based on an intraocular pressure state of a glaucoma patient.

Abstract: The present invention relates to a biocompatible polydopamine nanomotor capable of infiltrating a bladder wall in a biological environment and remaining inside a bladder for a long time.

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

Abstract: Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using supramolecular complexes that form a defined gel structure in situ. Such gels can serve as cellular or acellular matrices with or without certain encapsulated therapeutic factors to facilitate tissue regeneration such as multilayered re-epithelialization of wounded corneal stromal tissue.

Abstract: The present invention relates to a contact lens for diagnosis and treatment of dry eye syndrome. The contact lens, according to the present invention, may diagnose dry eye syndrome by means of a change in an electric current occurring as a result of a field effect when a dry eye syndrome biomarker binds to a probe, and when dry eye syndrome is diagnosed, generates an electric current so that a gold film blocking a drug reservoir melts by the electric current, thereby enabling the release of a drug to be controlled.

Abstract: The present invention relates to a system for corneal crosslinking of injured corneas, treating keratoconus, or correcting vision, the system comprising: a hyaluronic acid-dye conjugate; and a contact lens including an LED light source. In the present invention, a dye is activated by receiving light irradiated from the LED light source of the contact lens so as to generate radicals, thereby generating a covalent bond between amino acid radicals of corneal collagen, and strengthening a collagen layer. In the present invention, the hyaluronic acid-dye conjugate, in which hyaluronic acid is bound to the dye, is used to improve penetration of the dye in the cornea, and the contact lens is used together with the hyaluronic acid-dye conjugate to further improve the penetration of the dye. In addition, the structure of the lens which presses the center of the cornea deforms the shape of the cornea, thereby having a vision correction effect.

Abstract: A hydrogel prepared through the supramolecular self-assembly of cyclodextrin and adamantane is described. The hydrogel can be filled with drugs and cells and used for various diseases. The hydrogel uses hyaluronic acid and thus can be applied to transdermal delivery, in vivo drug release, intractable disease treatment using stem cells, etc.

Abstract: A hyaluronic acid-drug conjugate synthesized by introducing a drug to an aldehyde group at the end of hyaluronic acid is provided. Such a hyaluronic acid-drug conjugate allows a drug to be conjugated without modifying the repeating structure of hyaluronic acid, thereby simplifying degradation products.

Abstract: The present invention relates to an electroceutical system for driving a photoelectric element implanted in a sub-retinal optic nerve using a smart photonic lens. According to the present invention, by artificially emitting the light of the smart photonic lens to a photoelectric element connected to the optic nerve, it is possible to utilize stimulation of the nerve with an electric current generated in the photoelectric element to treat various diseases.

Abstract: The present invention relates to a smart remotely controlled contact lens for diagnosing and treating diseases by using a micro-LED. The present invention can diagnose and treat diseases by using a micro-LED or -OLED disposed in a contact lens. Further, the present invention can treat various diseases by using signals according to light wavelengths detected through a photodetector to control drug release from a drug delivery system in the contact lens. The drug delivery system that is a small-sized ocular insert can be electrically controlled. Accordingly, drug can be released from the drug delivery system at a desired time, and thus the drug delivery system can be applied to treatment of various diseases. Further, the photodetector can detect the therapeutic effect in real time through light reflected from a treated target cell, and thus the disease progression in a patient can be easily and quickly checked.

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

Abstract: One aspect of the present disclosure relates to a remotely controllable lens device. The lens device can include a lens material and a circuit physically coupled to the lens material. The circuit can be configured to be powered based on an energy signal from a power source to perform a function (e.g., release of drug, generation of electromagnetic radiation, detection of electromagnetic radiation, and/or control of an optical refractive property). For example, the power source can be an external power source and/or an auto-powered source. The external power source can be, for example, a power source that utilizes synchronized magnetic flux phase coupling (e.g., WiTricity). The auto-powered source can be provided on-site (e.g., on-chip) using a harvesting system (e.g., solar-cell, photo-cell, piezoelectric, etc.

Abstract: The present invention provides a smart contact lens including a sensor capable of non-invasively sensing an eye disease in real time and a drug reservoir, and smart glasses for controlling the smart contact lens.

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

Abstract: A transdermal delivery system of drug and a method of preparing the same are provided. More specifically, the invention can be a transdermal delivery system applied for various protein drugs such as vaccines and chemical drugs, because the drug delivery system has a biocompatibility, biodegradation property, transdermal delivery property, the safety of human body, maximum activity of protein drugs, good bio-conjugation efficiency and a long-term efficacy, a method of preparing the same and its use.

Abstract: The present invention provides a smart contact lens including a sensor capable of non-invasively sensing an eye disease in real time and a drug reservoir, and smart glasses for controlling the smart contact lens.

Abstract: Disclosed is a complex for remedying or treating a retinal disease. The complex includes a hyaluronic acid or a derivative thereof, a carbon nanomaterial covalently bonded to the hyaluronic acid or the derivative thereof, and a photosensitizer bonded to the carbon nanomaterial. The complex for remedying or treating the retinal disease according to the present invention includes a hyaluronic acid-carbon nanomaterial-photosensitizer complex, thus selectively preventing the formation of active oxygen in retinal pigment epithelium cells for a relatively long period of time. Accordingly, the complex has excellent therapeutic efficacy and easily infiltrates into cells. Further, the present invention provides a composition for remedying or treating a retinal disease including the hyaluronic acid-carbon nanomaterial-photosensitizer complex.

Abstract: Provided are a hyaluronic acid derivative for liver-targeting delivery via intravenous injection of cells and a preparation method thereof. More particularly, provided are a preparation method of a hyaluronic acid derivative capable of modifying the surface of cells and also having biocompatibility, biodegradability, and liver-targeting deliver property, and use of the hyaluronic acid derivative prepared thereby as a liver-targeting cell delivery system.