Patents by Inventor Sei Kwang Hahn
Sei Kwang Hahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME
Publication number: 20160243246Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.Type: ApplicationFiled: May 11, 2016Publication date: August 25, 2016Inventors: Sei Kwang HAHN, Kitae Park, Jeonga Yang, Won Ho Kong, Min Young Lee -
Publication number: 20160223842Abstract: One aspect of the present disclosure relates to a remotely controllable lens device. The lens device can include a lens material and a circuit physically coupled to the lens material. The circuit can be configured to be powered based on an energy signal from a power source to perform a function (e.g., release of drug, generation of electromagnetic radiation, detection of electromagnetic radiation, and/or control of an optical refractive property). For example, the power source can be an external power source and/or an auto-powered source. The external power source can be, for example, a power source that utilizes synchronized magnetic flux phase coupling (e.g., WiTricity). The auto-powered source can be provided on-site (e.g., on-chip) using a harvesting system (e.g., solar-cell, photo-cell, piezoelectric, etc.Type: ApplicationFiled: September 9, 2014Publication date: August 4, 2016Inventors: Seok-Hyun Yun, Ehsan Kamrani, Sei Kwang Hahn, Hyemin Kim, Dohee Keum, Keon Jae Lee, Choun-Ki Joo
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Publication number: 20160174885Abstract: The present invention relates to a microneedle, a sensor for detecting nitrogen monoxide, including the microneedle, a medical apparatus including the microneedle, and a manufacturing method thereof. The microneedle of the present invention may detect whether nitrogen monoxide is present or not by using electrochemical principles. Further, a change in concentration of nitrogen monoxide may be sensed in real time. The effects of detecting nitrogen monoxide may be used to diagnose cancer and forecast the size and growth degree of a tumor.Type: ApplicationFiled: September 16, 2015Publication date: June 23, 2016Inventors: Sei Kwang HAHN, Dohee KEUM, Ho Sang JUNG, Hyemin KIM, Myeong Hwan SHIN
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Patent number: 9221893Abstract: An HA-protein conjugate in which an HA-aldehyde derivative, in which an aldehyde group is introduced to a hyaluronic acid or a salt thereof, is conjugated to the N-terminus of a protein, and a method for preparing the same are provided. The HA-protein conjugate includes a protein drug exhibiting an excellent bioconjugation efficiency and long-term medicinal effects, and has excellent protein drug activities since the hyaluronic acid is specifically conjugated to the N-terminus of the protein. Also, since liver-targeting properties of the hyaluronic acid can be freely controlled by changing an aldehyde substitution rate of the HA-aldehyde derivative, the HA-protein conjugate can be effectively used as a protein drug for treating liver diseases, and also be useful in enabling long-term medicinal effects of a protein drug required to bypass the liver. Accordingly, the HA-protein conjugate can be effectively used for a drug delivery system of proteins.Type: GrantFiled: December 5, 2011Date of Patent: December 29, 2015Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang Hahn, Jeong A. Yang, Seung Kyu Yoon, Won Hee Hur, Ki Tae Park, Hye Min Kim, Hyun Tae Jung
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Publication number: 20150297749Abstract: This disclosure relates to a low density lipoprotein-like cationic solid lipid nanoparticle targeting liver cells including parenchyma cells and non-parenchyma cells, a composition for liver target delivery, a composition for diagnosis and/or treatment of liver disease comprising the same, and a method for liver targeting of an active ingredient.Type: ApplicationFiled: October 2, 2013Publication date: October 22, 2015Inventors: Sei Kwang HAHN, Won Ho KONG, Kitae PARK
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Patent number: 9101669Abstract: Provided are a self-assembled conjugate of a host molecule containing compound and a guest molecule containing compound, a delivery composition of a bioactive material comprising the self-assembled conjugate and a bioactive material to be delivered, and a composition for tissue engineering containing the self-assembled conjugate and a cell.Type: GrantFiled: January 31, 2012Date of Patent: August 11, 2015Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang Hahn, Kimoon Kim, Hyuntae Jung, Jeong-A Yang, Kyeng Min Park
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Publication number: 20150150994Abstract: The present invention relates to liver targeted drug delivery system using metal nanoparticles and a method for preparing the same. More particularly, the present invention relates to a method for preparing hyaluronic acid-gold nanoparticles/protein complex that can be used as liver targeted drug delivery system, by surface modifying gold nanoparticles having excellent stability in the body with hyaluronic acid having biocompatibility, biodegradability and liver tissue-specific delivery property, and binding protein drugs for treating liver diseases to the non-modified surface of the gold nanoparticles. And, the present invention relates to use of the hyaluronic acid-gold nanoparticles/protein complex for liver disease drug that may be safely applied to human body, increase drug efficacy duration time, and be effectively delivered to liver.Type: ApplicationFiled: May 21, 2013Publication date: June 4, 2015Inventors: Sei Kwang Hahn, Min Young Lee, Jeonga Yang, Ho Sang Jung
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Patent number: 9017712Abstract: The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.Type: GrantFiled: July 11, 2011Date of Patent: April 28, 2015Assignees: Shin Poong Pharmaceutical Co., Ltd., Postech Academy-Industry FoundationInventors: Il Hwan Cho, Eui Jin Hwang, Moo Seok Seo, Young Soo Park, Byung Su Kim, Sei Kwang Hahn, Jung Kyu Park, Jun Seok Yeom, Eun Ju Oh
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Publication number: 20150056254Abstract: A transdermal delivery system of drug and a method of preparing the same are provided. More specifically, the invention can be a transdermal delivery system applied for various protein drugs such as vaccines and chemical drugs, because the drug delivery system has a biocompatibility, biodegradation property, transdermal delivery property, the safety of human body, maximum activity of protein drugs, good bio-conjugation efficiency and a long-term efficacy, a method of preparing the same and its use.Type: ApplicationFiled: February 7, 2013Publication date: February 26, 2015Applicant: PHI BioMed Co., Ltd.Inventors: Sei Kwang Hahn, Eung-Sam Kim, Jeonga Yang, Hyemin Kim, Kwan Yong Choi, Ji Hye Shin, Jung-Hee Kwon
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Patent number: 8895069Abstract: The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.Type: GrantFiled: December 15, 2011Date of Patent: November 25, 2014Assignee: Postech Academy-Industry FoundationInventors: Sei Kwang Hahn, Choun-Ki Joo, Yoon Keun Kim, Seung Kew Yoon, Eun Ju Oh, Ki Su Kim, Hyemin Kim, Kitae Park, Jeong-A Yang, Jun-Sub Choi, You Me Tae, Wonhee Hur
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Patent number: 8747903Abstract: The present invention relates to a composition for nucleic acid delivery and a method for preparing the same, more particularly to a composition for nucleic acid delivery having excellent stability in the body environment and excellent intracellular delivery efficiency of nucleic acid, and enabling target directed delivery of nucleic acid, and a method for preparing the same.Type: GrantFiled: March 27, 2012Date of Patent: June 10, 2014Assignee: Postech Academy-Industry FoundationInventors: Sei Kwang Hahn, Min-Young Lee, Kitae Park, Ki Su Kim, Hwiwon Lee
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Patent number: 8703740Abstract: The present invention relates to a composition for preventing tissue adhesion which comprising a bio-compatible hyaluronic acid and a polymer compound. More specifically, the invention is a composition containing hyaluronic acid which has not been modified by a chemical crosslinking or other chemical modification a method for preparing the same, and a composition for adhesion prevention with superior efficacy. The composition of the present invention for preventing adhesion exhibits a physical barrier function and a new adhesion prevention function whereby thrombus formation, which is the basis of adhesion, is inhibited.Type: GrantFiled: November 25, 2009Date of Patent: April 22, 2014Assignees: Shin Poong Pharmaceutical Co., Ltd., Postech Academy-Industry FoundationInventors: Il Hwan Cho, Sei Kwang Hahn, Eui Jin Hwang, Jang Sik Shin, Junseok Yeom
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HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME
Publication number: 20140080897Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.Type: ApplicationFiled: September 16, 2013Publication date: March 20, 2014Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang HAHN, Kitae Park, Jeonga Yang, Won Ho Kong, Min Young Lee -
Patent number: 8575332Abstract: The present invention provides long-acting sustained-release formulations of drugs such as proteins or peptides, which are injectable, completely biodegradable and safe, as well as ensuring efficient encapsulation of the drugs such as proteins or peptides without inhibiting their biological activity. It is possible to achieve injectable sustained-release formulations that ensure efficient encapsulation and long-term sustained release of drugs such as proteins or peptides while retaining their biological activity, when a solution containing a drug and a polysaccharide derivative such as hyaluronic acid having a crosslinkable functional group(s) or a salt thereof is dehydrated in microparticulate form starting from a dilute state, where crosslinking proceeds slowly, to reach a concentration which facilitates crosslinking, to thereby cause crosslinking reaction during concentration, so that the drug is encapsulated into the crosslinked polysaccharide to give drug-carrying microparticles.Type: GrantFiled: November 15, 2004Date of Patent: November 5, 2013Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Sei Kwang Hahn, Tsuyoshi Shimoboji
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Publication number: 20130253170Abstract: An HA-protein conjugate in which an HA-aldehyde derivative, in which an aldehyde group is introduced to a hyaluronic acid or a salt thereof, is conjugated to the N-terminus of a protein, and a method for preparing the same are provided. The HA-protein conjugate includes a protein drug exhibiting an excellent bioconjugation efficiency and long-term medicinal effects, and has excellent protein drug activities since the hyaluronic acid is specifically conjugated to the N-terminus of the protein. Also, since liver-targeting properties of the hyaluronic acid can be freely controlled by changing an aldehyde substitution rate of the HA-aldehyde derivative, the HA-protein conjugate can be effectively used as a protein drug for treating liver diseases, and also be useful in enabling long-term medicinal effects of a protein drug required to bypass the liver. Accordingly, the HA-protein conjugate can be effectively used for a drug delivery system of proteins.Type: ApplicationFiled: December 5, 2011Publication date: September 26, 2013Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang Hahn, Jeong A. Yang, Seung Kyu Yoon, Won Hee Hur, Ki Tae Park, Hye Min Kim, Hyun Tae Jung
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Publication number: 20130203856Abstract: The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.Type: ApplicationFiled: July 11, 2011Publication date: August 8, 2013Applicants: Postech Academy-Industry Foundation, Shin Poon Pharmaceutical Co., Ltd.Inventors: Il Hwan Cho, Eui Jin Hwang, Moo Seok Seo, Young Soo Park, Byung Su Kim, Sei Kwang Hahn, Jung Kyu Park, Jun Seok Yeom, Eun Ju Oh
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Publication number: 20130195751Abstract: Provided are a self-assembled conjugate of a host molecule containing compound and a guest molecule containing compound, a delivery composition of a bioactive material comprising the self-assembled conjugate and a bioactive material to be delivered, and a composition for tissue engineering containing the self-assembled conjugate and a cell.Type: ApplicationFiled: January 31, 2012Publication date: August 1, 2013Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang HAHN, Kimoon KIM, Hyuntae JUNG, Jeong-A YANG, Kyeng Min PARK
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Publication number: 20130095187Abstract: The present invention relates to a composition for nucleic acid delivery and a method for preparing the same, more particularly to a composition for nucleic acid delivery having excellent stability in the body environment and excellent intracellular delivery efficiency of nucleic acid, and enabling target directed delivery of nucleic acid, and a method for preparing the same.Type: ApplicationFiled: March 27, 2012Publication date: April 18, 2013Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang HAHN, Min-Young Lee, Kitae Park, Ku Su Kim, Hwiwon Lee
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Patent number: 8318856Abstract: The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.Type: GrantFiled: April 4, 2008Date of Patent: November 27, 2012Assignees: Postech Academy-Industry Foundation, Korea University Industry and Academy Collaboration FoundationInventors: Yu-Kyoung Oh, Hyun-Gu Kang, Ji-Seok Kim, Jiang Ge, Ki-Su Kim, Ki-Tae Park, Su-Eun Han, Ga-Yong Shim, Ii-Hwan Cho, Sei-Kwang Hahn
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Publication number: 20120294945Abstract: The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.Type: ApplicationFiled: December 15, 2011Publication date: November 22, 2012Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang HAHN, Choun-Ki Joo, Yoon Keun Kim, Seung Kew Yoon, Eun Ju Oh, Ki Su Kim, Hyemin Kim, Kitae Park, Jeong-A Yang, Jun-sub Choi, You Me Tae, Wonhee Hur