Patents by Inventor Seiichi Hara
Seiichi Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11935282Abstract: A server of a crop growth stage determination system includes a processor. The processor inputs first images obtained by image capturing crops in a manner such that crop shapes are extractable. The Processor inputs growth stages each indicating a level of physiological growth of the crops for each of the first images. The processor constructs a learned model by performing deep learning to associate images of the crops and growth stages of the crops based on the input first images and the input growth stage. The processor inputs a second image obtained by image capturing crops a growth stage of which is unknown, in a manner such that crop-shapes are extractable. The processor determines the growth stage for the input second image based on the learned model. The processor outputs the determined growth stage.Type: GrantFiled: February 26, 2021Date of Patent: March 19, 2024Assignees: NTT DATA CCS CORPORATIONInventors: Norio Iwasawa, Aritoshi Mio, Seiichi Hara, Hiroto Shimojo, Hiroshi Takemoto
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Publication number: 20230159968Abstract: The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields, even if an inorganic selenium compound is used as a selenium compound. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant to obtain selenoneine, wherein the transformant has at least one gene selected from the group consisting of a SatA gene, a CysB gene and a MetR gene, and an EgtA gene inserted therein and can overexpress the inserted genes.Type: ApplicationFiled: June 14, 2019Publication date: May 25, 2023Applicant: KIKKOMAN CORPORATIONInventors: Seiichi HARA, Keiichi ICHIKAWA
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Patent number: 11629341Abstract: The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine. (1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).Type: GrantFiled: May 13, 2021Date of Patent: April 18, 2023Assignee: KIKKOMAN CORPORATIONInventors: Keiichi Ichikawa, Yasutomo Shinohara, Seiichi Hara, Keiko Kurosawa, Yumiko Yamashita, Michiaki Yamashita
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Publication number: 20210403929Abstract: The objective of the present invention is to provide a transformed Aspergillus microorganism lacking at least two types of selection marker genes available for marker recycling method and a composition therefor. The objective can be achieved by a transformed Aspergillus microorganism lacking at least two types of selection marker genes available for marker recycling method on its chromosomes, or a composition for transforming an Aspergillus microorganism containing at least two types of nucleic acid fragments containing a loop-out region and a selection marker gene available for marker recycling method between homologous recombination regions, wherein the selection marker genes contain a tryptophan biosynthesis gene and a gene different from tryptophan biosynthesis gene.Type: ApplicationFiled: November 4, 2019Publication date: December 30, 2021Applicant: KIKKOMAN CORPORATIONInventor: Seiichi HARA
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Patent number: 11208466Abstract: A cytochrome b-glucose dehydrogenase fusion protein having modified electron transfer properties, and a glucose measurement method and measuring kit using the cytochrome b-glucose dehydrogenase fusion protein are provided. Provided are a cytochrome b-glucose dehydrogenase fusion protein in which glucose dehydrogenase having homology with SEQ ID NO: 1 or SEQ ID NO: 4 and cytochrome b are linked together, as well as a glucose measurement method, a measurement reagent kit and a sensor using the cytochrome b-glucose dehydrogenase fusion protein. The cytochrome b-glucose dehydrogenase fusion protein of the present invention has modified electron transfer properties, and can be used for measuring glucose in the presence of a free-form mediator in reduced concentration or in the absence of a free-form mediator, and can be used, for example, in continuous glucose monitoring.Type: GrantFiled: November 30, 2016Date of Patent: December 28, 2021Assignee: KIKKOMAN CORPORATIONInventors: Yosuke Masakari, Seiichi Hara
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Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
Patent number: 11186855Abstract: The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5?-phosphate as a coenzyme.Type: GrantFiled: April 27, 2020Date of Patent: November 30, 2021Assignee: KIKKOMAN CORPORATIONInventors: Seiichi Hara, Keiko Kurosawa, Keiichi Ichikawa -
Publication number: 20210317463Abstract: The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine. (1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).Type: ApplicationFiled: May 13, 2021Publication date: October 14, 2021Applicant: KIKKOMAN CORPORATIONInventors: Keiichi ICHIKAWA, Yasutomo SHINOHARA, Seiichi HARA, Keiko KUROSAWA, Yumiko YAMASHITA, Michiaki YAMASHITA
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Patent number: 11073216Abstract: The present invention provides a flow channel switching valve with a reduced number of components as well as a reduced weight, and a method for assembling the same. A valve shaft adapted to be coupled to a valve element so as to transmit torque of a rotary drive portion to the valve element is inserted through a vertical through-hole, which penetrates through the valve element in the direction of the rotation axis O (i.e., vertical direction), and through a fit-insertion hole provided in a valve body. Then, a drive gear that forms the rotary drive portion is fixed to the upper coupling portion of the valve shaft protruding from the fit-insertion hole so that the valve shaft is rotatably supported with respect to the valve body.Type: GrantFiled: January 17, 2017Date of Patent: July 27, 2021Assignee: FUJIKOKI CORPORATIONInventors: Daisuke Kondo, Kenichi Mochizuki, Masashi Yamashita, Seiichi Hara, Takayuki Matsumoto
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Patent number: 11046993Abstract: A glucose dehydrogenase having modified electron transfer properties, and a glucose measurement method and measuring kit using the glucose dehydrogenase are provided. Provided are a glucose dehydrogenase having at least 1, 2 or 3 amino acid substitutions, for example, amino acid substitution with a polar amino acid or alanine, in the region corresponding to the 457th to 477th position in SEQ ID NO: 1 of a glucose dehydrogenase having homology with SEQ ID NO: 1, a glucose measurement method, a measurement reagent kit and a sensor using the glucose dehydrogenase. The electron transfer properties of the glucose dehydrogenase of the present invention is modified and can be used in measuring glucose in the presence of a mediator with reduced concentration or in the absence of a mediator, and can be used, for example, in continuous glucose measurement.Type: GrantFiled: October 31, 2016Date of Patent: June 29, 2021Assignee: KIKKOMAN CORPORATIONInventors: Yosuke Masakari, Seiichi Hara
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Publication number: 20210183045Abstract: A server of a crop growth stage determination system includes a processor. The processor inputs first images obtained by image capturing crops in a manner such that crop shapes are extractable. The Processor inputs growth stages each indicating a level of physiological growth of the crops for each of the first images. The processor constructs a learned model by performing deep learning to associate images of the crops and growth stages of the crops based on the input first images and the input growth stage. The processor inputs a second image obtained by image capturing crops a growth stage of which is unknown, in a manner such that crop-shapes are extractable. The processor determines the growth stage for the input second image based on the learned model. The processor outputs the determined growth stage.Type: ApplicationFiled: February 26, 2021Publication date: June 17, 2021Applicants: NTT DATA CCS CORPORATIONInventors: Norio IWASAWA, Aritoshi MIO, Seiichi HARA, Hiroto SHIMOJO, Hiroshi TAKEMOTO
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Patent number: 11028400Abstract: The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine. (1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).Type: GrantFiled: June 17, 2016Date of Patent: June 8, 2021Assignee: KIKKOMAN CORPORATIONInventors: Keiichi Ichikawa, Yasutomo Shinohara, Seiichi Hara, Keiko Kurosawa, Yumiko Yamashita, Michiaki Yamashita
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TRANSFORMED FUNGUS HAVING ENHANCED ERGOTHIONEINE PRODUCTIVITY AND METHOD FOR PRODUCING ERGOTHIONEINE
Publication number: 20200318147Abstract: The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5?-phosphate as a coenzyme.Type: ApplicationFiled: April 27, 2020Publication date: October 8, 2020Applicant: KIKKOMAN CORPORATIONInventors: Seiichi HARA, Keiko KUROSAWA, Keiichi ICHIKAWA -
Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
Patent number: 10760107Abstract: The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5?-phosphate as a coenzyme.Type: GrantFiled: December 25, 2015Date of Patent: September 1, 2020Assignee: KIKKOMAN CORPORATIONInventors: Seiichi Hara, Keiko Kurosawa, Keiichi Ichikawa -
Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
Patent number: 10711290Abstract: The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5?-phosphate as a coenzyme.Type: GrantFiled: December 25, 2015Date of Patent: July 14, 2020Assignee: KIKKOMAN CORPORATIONInventors: Seiichi Hara, Keiko Kurosawa, Keiichi Ichikawa -
Publication number: 20200141502Abstract: The present invention provides a flow channel switching valve with a reduced number of components as well as a reduced weight, and a method for assembling the same. A valve shaft adapted to be coupled to a valve element so as to transmit torque of a rotary drive portion to the valve element is inserted through a vertical through-hole, which penetrates through the valve element in the direction of the rotation axis O (i.e., vertical direction), and through a fit-insertion hole provided in a valve body. Then, a drive gear that forms the rotary drive portion is fixed to the upper coupling portion of the valve shaft protruding from the fit-insertion hole so that the valve shaft is rotatably supported with respect to the valve body.Type: ApplicationFiled: November 9, 2017Publication date: May 7, 2020Applicant: Fujikoki CorporationInventors: Daisuke KONDO, Kenichi MOCHIZUKI, Masashi YAMASHITA, Seiichi HARA, Takayuki MATSUMOTO
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Publication number: 20180355022Abstract: A cytochrome b-glucose dehydrogenase fusion protein having modified electron transfer properties, and a glucose measurement method and measuring kit using the cytochrome b-glucose dehydrogenase fusion protein are provided. Provided are a cytochrome b-glucose dehydrogenase fusion protein in which glucose dehydrogenase having homology with SEQ ID NO: 1 or SEQ ID NO: 4 and cytochrome b are linked together, as well as a glucose measurement method, a measurement reagent kit and a sensor using the cytochrome b-glucose dehydrogenase fusion protein. The cytochrome b-glucose dehydrogenase fusion protein of the present invention has modified electron transfer properties, and can be used for measuring glucose in the presence of a free-form mediator in reduced concentration or in the absence of a free-form mediator, and can be used, for example, in continuous glucose monitoring.Type: ApplicationFiled: November 30, 2016Publication date: December 13, 2018Inventors: Yosuke MASAKARI, Seiichi HARA
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Publication number: 20180340211Abstract: A glucose dehydrogenase having modified electron transfer properties, and a glucose measurement method and measuring kit using the glucose dehydrogenase are provided. Provided are a glucose dehydrogenase having at least 1, 2 or 3 amino acid substitutions, for example, amino acid substitution with a polar amino acid or alanine, in the region corresponding to the 457th to 477th position in SEQ ID NO: 1 of a glucose dehydrogenase having homology with SEQ ID NO: 1, a glucose measurement method, a measurement reagent kit and a sensor using the glucose dehydrogenase. The electron transfer properties of the glucose dehydrogenase of the present invention is modified and can be used in measuring glucose in the presence of a mediator with reduced concentration or in the absence of a mediator, and can be used, for example, in continuous glucose measurement.Type: ApplicationFiled: October 31, 2016Publication date: November 29, 2018Inventors: Yosuke MASAKARI, Seiichi HARA
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Publication number: 20180237815Abstract: The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine. (1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).Type: ApplicationFiled: June 17, 2016Publication date: August 23, 2018Applicant: KIKKOMAN CORPORATIONInventors: Keiichi ICHIKAWA, Yasutomo SHINOHARA, Seiichi HARA, Keiko KUROSAWA, Yumiko YAMASHITA, Michiaki YAMASHITA
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Patent number: 10035747Abstract: The present invention provides a method for allowing a used inert material that has been subjected to a reaction once, which is disposed of in the background art, to be used again as well as a brand-new one. A method of recovering an inert material of the present invention is characterized by in the fixed-bed reactor, the inert material is loaded in an inert material layer provided between a first-stage catalyst layer and a second-stage catalyst layer, the first-stage catalyst layer is loaded with a first-stage catalyst for producing acrolein from propylene, and the second-stage catalyst layer is loaded with a second-stage catalyst for producing acrylic acid from acrolein, the method comprising the steps of: extracting the inert material from the fixed-bed reactor; washing the extracted inert material; and screening the washed inert material.Type: GrantFiled: July 30, 2015Date of Patent: July 31, 2018Assignee: NIPPON SHOKUBAI CO., LTD.Inventors: Yasuhiro Mimura, Fumio Munechika, Hisao Kakuta, Motoki Hisanaga, Seiichi Hara
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Publication number: 20170354900Abstract: A method for purifying an easily polymerizable substance efficiently to improve the troublesome matters when cleaning, e.g., reducing the number of times the metal mesh is cleaned. The method for purifying an easily polymerizable substance of the present invention comprises a step of introducing a crude liquid containing the easily polymerizable substance into a distillation column, and a first separation step of introducing a bottoms liquid extracted from a collection part of the distillation column into a wet cyclone, to separate a first purified liquid containing the easily polymerizable substance from a liquid containing an insoluble solid.Type: ApplicationFiled: November 20, 2015Publication date: December 14, 2017Applicant: NIPPON SHOKUBAI CO., LTD.Inventors: Hiroki IMAZU, Masahiro MOTOFUJI, Hisao KAKUTA, Motoki HISANAGA, Seiichi HARA