Patents by Inventor Seiji Niwa
Seiji Niwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10173263Abstract: An additive manufacturing apparatus includes a shaping part, a powder feeding part that feeds the powder material to the shaping part, a powder storage part that stores the powder material, and a pipe through which the powder material is transferred from the powder storage part to the powder feeding part. The powder storage part is arranged on a lower side of the powder feeding part in the vertical direction. The pipe is provided with a bent part in a transfer section in which the powder material is transferred from a lower side to an upper side in the vertical direction. The bent part stops the falling of the powder material that is present in the transfer section in the middle of the transfer section when the suction is stopped.Type: GrantFiled: April 6, 2016Date of Patent: January 8, 2019Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Katsuji Harajiri, Yoshiyuki Mitsuya, Takeshi Kimura, Michiyoshi Keta, Seiji Niwa, Katsuhiro Ito
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Publication number: 20180079715Abstract: A method for producing an alkylamine derivative having a urea bond represented by formula (I), or a salt thereof, comprises the following steps (a) and (b), step (a): and step (b): deprotecting as necessary the reaction product obtained in step (a). The production method suitable for industrialization of the alkylamine derivative having a urea bond represented by formula (I), which is a compound highly useful as an agent having CaSR agonist effects is provided.Type: ApplicationFiled: November 30, 2017Publication date: March 22, 2018Applicant: AJINOMOTO CO., INC.Inventors: Kotaro OKADO, Nobuteru ABE, Shin MURONOI, Yasuhisa KOBAYASHI, Seiji NIWA, Toshihiro MATSUZAWA
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Publication number: 20160297005Abstract: An additive manufacturing apparatus includes a shaping part, a powder feeding part that feeds the powder material to the shaping part, a powder storage part that stores the powder material, and a pipe through which the powder material is transferred from the powder storage part to the powder feeding part. The powder storage part is arranged on a lower side of the powder feeding part in the vertical direction. The pipe is provided with a bent part in a transfer section in which the powder material is transferred from a lower side to an upper side in the vertical direction. The bent part stops the falling of the powder material that is present in the transfer section in the middle of the transfer section when the suction is stopped.Type: ApplicationFiled: April 6, 2016Publication date: October 13, 2016Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Katsuji HARAJIRI, Yoshiyuki MITSUYA, Takeshi KIMURA, Michiyoshi KETA, Seiji NIWA, Katsuhiro ITO
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Patent number: 9352401Abstract: An indexable ball end mill comprising first to third inserts having arcuate cutting edges detachably attached with first to third screws to first to third seats in a semispherical tip end portion of a tool body; a first threaded hole for the first screw slantingly penetrating a slit-shaped first seat; the first insert having an inclined hole to avoid interference between the first screw and the second and third screws; a hole of the first insert and the first screw having at least partially finished surfaces, so that when the first screw penetrates the first insert attached to the first seat, the first insert is precisely positioned by tight engagement of both finished surfaces.Type: GrantFiled: March 5, 2012Date of Patent: May 31, 2016Assignee: Mitsubishi Hitachi Tool Engineering, Ltd.Inventors: Yoshimitsu Nagashima, Yoshiyuki Kobayashi, Haruhisa Higasayama, Seiji Niwa
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Publication number: 20130336731Abstract: An indexable ball end mill comprising first to third inserts having arcuate cutting edges detachably attached with first to third screws to first to third seats in a semispherical tip end portion of a tool body; a first threaded hole for the first screw slantingly penetrating a slit-shaped first seat; the first insert having an inclined hole to avoid interference between the first screw and the second and third screws; a hole of the first insert and the first screw having at least partially finished surfaces, so that when the first screw penetrates the first insert attached to the first seat, the first insert is precisely positioned by tight engagement of both finished surfaces.Type: ApplicationFiled: March 5, 2012Publication date: December 19, 2013Applicant: HITACHI TOOL ENGINEERING, LTD.Inventors: Yoshimitsu Nagashima, Yoshiyuki Kobayashi, Haruhisa Higasayama, Seiji Niwa
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Patent number: 8299064Abstract: The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R? represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R? represent a hydrogen atom.Type: GrantFiled: March 4, 2011Date of Patent: October 30, 2012Assignee: Ajinomoto Co., Inc.Inventors: Ryusuke Hirama, Seiji Niwa, Hideyuki Tanaka, Toshihiro Hatanaka, Yoko Masuzawa, Akiyo Yamazaki, Takao Ikenoue, Nobuo Kondo, Wataru Miyanaga, Masaru Takayanagi
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Patent number: 8278329Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: GrantFiled: October 26, 2007Date of Patent: October 2, 2012Assignee: Ajinomoto Co., Inc.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Publication number: 20110160191Abstract: The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R? represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R? represent a hydrogen atom.Type: ApplicationFiled: March 4, 2011Publication date: June 30, 2011Applicant: Ajinomoto Co., Inc.Inventors: Ryusuke HIRAMA, Seiji Niwa, Hideyuki Tanaka, Toshihiro Hatanaka, Yoko Masuzawa, Akiyo Yamazaki, Takao Ikenoue, Nobuo Kondo, Wataru Miyanaga, Masaru Takayanagi
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Patent number: 7928101Abstract: The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R? represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R? represent a hydrogen atom.Type: GrantFiled: May 1, 2006Date of Patent: April 19, 2011Assignee: Ajinomoto Co., Inc.Inventors: Ryusuke Hirama, Seiji Niwa, Hideyuki Tanaka, Toshihiro Hatanaka, Yoko Masuzawa, Akiyo Yamazaki, Takao Ikenoue, Nobuo Kondo, Wataru Miyanaga, Masaru Takayanagi
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Patent number: 7834006Abstract: The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, R10 and R13 are hydrogen atoms, and R11 and R12 are methyl groups.Type: GrantFiled: July 14, 2006Date of Patent: November 16, 2010Assignee: Ajinomoto Co., Inc.Inventors: Ryusuke Hirama, Hideyuki Tanaka, Seiji Niwa, Akiyo Yamazaki, Takao Ikenoue, Koji Ohsumi
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Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
Patent number: 7713957Abstract: The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.Type: GrantFiled: August 5, 2004Date of Patent: May 11, 2010Assignee: Ajinomoto Co., Inc.Inventors: Satoshi Iwayama, Hajime Koganei, Shinichi Fujita, Tomoko Takeda, Hiroshi Yamamoto, Seiji Niwa -
Patent number: 7632830Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.Type: GrantFiled: November 30, 2007Date of Patent: December 15, 2009Assignee: Ajinomoto Co., Inc.Inventors: Yukio Iino, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
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Patent number: 7494989Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.Type: GrantFiled: September 17, 2007Date of Patent: February 24, 2009Assignee: Ajinomoto Co., Inc.Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Patent number: 7462630Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: GrantFiled: February 27, 2004Date of Patent: December 9, 2008Assignee: Ajinomoto Co., Inc.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Publication number: 20080096862Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.Type: ApplicationFiled: November 30, 2007Publication date: April 24, 2008Applicant: Ajinomoto Co., Inc.Inventors: Yukio IINO, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
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Publication number: 20080070903Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.Type: ApplicationFiled: September 17, 2007Publication date: March 20, 2008Applicant: AJINOMOTO CO., INCInventors: Seiji OHNO, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Publication number: 20080058311Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: ApplicationFiled: October 26, 2007Publication date: March 6, 2008Applicant: AJINOMOTO CO., INC.Inventors: Takashi YAMAMOTO, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Patent number: 7326701Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.Type: GrantFiled: April 6, 2006Date of Patent: February 5, 2008Assignee: Ajinomoto Co., Inc.Inventors: Yukio Iino, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
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Patent number: 7288544Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally.Type: GrantFiled: March 14, 2003Date of Patent: October 30, 2007Assignee: Ajinomoto Co., Inc.Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Patent number: 7247645Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.Type: GrantFiled: December 20, 2001Date of Patent: July 24, 2007Assignee: Ajinomoto Co., Inc.Inventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei