Patents by Inventor Seiji Niwa

Seiji Niwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lactam compounds and pharmaceutical use thereof
    Patent number: 7153850
    Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: December 26, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yukio Iino, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
  • Fused polycyclic compounds
    Publication number: 20060258637
    Abstract: The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, R10 and R13 are hydrogen atoms, and R11 and R12 are methyl groups.
    Type: Application
    Filed: July 14, 2006
    Publication date: November 16, 2006
    Applicant: AJINOMOTO CO. INC
    Inventors: Ryusuke Hirama, Hideyuki Tanaka, Seiji Niwa, Akiyo Yamazaki, Takao Ikenoue, Koji Ohsumi
  • Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof
    Publication number: 20060194789
    Abstract: The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R? represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R? represent a hydrogen atom.
    Type: Application
    Filed: May 1, 2006
    Publication date: August 31, 2006
    Applicant: Ajinomoto Co., Inc.
    Inventors: Ryusuke Hirama, Seiji Niwa, Hideyuki Tanaka, Toshihiro Hatanaka, Yoko Masuzawa, Akiyo Yamazaki, Takao Ikenoue, Nobuo Kondo, Wataru Miyanaga, Masaru Takayanagi
  • Lactam compounds and pharmaceutical use thereof
    Publication number: 20060189597
    Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
    Type: Application
    Filed: April 6, 2006
    Publication date: August 24, 2006
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yukio Ilno, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
  • Dihydropyridine derivative
    Patent number: 6995179
    Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: February 7, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisayuki Uneyama, Seiji Niwa, Tomoyuki Onishi
  • Dihydropyrimidine compounds and compositions containing the same
    Patent number: 6855716
    Abstract: Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: February 15, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Seiji Ohno, Akiko Okajima, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Yuki Kajigaya, Tomoko Takeda, Hajime Koganei
  • Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
    Publication number: 20050009814
    Abstract: The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.
    Type: Application
    Filed: August 5, 2004
    Publication date: January 13, 2005
    Applicant: Ajinomoto Co., Inc.
    Inventors: Satoshi Iwayama, Hajime Koganei, Shinichi Fujita, Tomoko Takeda, Hiroshi Yamamoto, Seiji Niwa
  • Novel diarylalkene derivatives and novel diarylalkane derivatives
    Publication number: 20040167118
    Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc.
    Type: Application
    Filed: February 27, 2004
    Publication date: August 26, 2004
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
  • Pyrimidine derivatives and new pyridine derivatives
    Publication number: 20040009991
    Abstract: Achirai pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.
    Type: Application
    Filed: March 14, 2003
    Publication date: January 15, 2004
    Applicant: AJINOMOTO CO., INC.
    Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
  • Dihydropyridine derivatives
    Publication number: 20020147222
    Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided.
    Type: Application
    Filed: December 20, 2001
    Publication date: October 10, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • Dihydropyrimidine compounds and compositions containing the same
    Publication number: 20020143023
    Abstract: Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels.
    Type: Application
    Filed: December 26, 2001
    Publication date: October 3, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Seiji Ohno, Akiko Okajima, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Yuki Kajigaya, Tomoko Takeda, Hajime Koganei
  • Novel dihydropyridine derivative
    Publication number: 20020111494
    Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.
    Type: Application
    Filed: December 13, 2001
    Publication date: August 15, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Hisayuki Uneyama, Seiji Niwa, Tomoyuki Onishi
  • Dihydropyridine derivative
    Patent number: 6350762
    Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: February 26, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Seiji Niwa, Seiji Ohno, Tomoyuki Onishi, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Hisayuki Uneyama
  • Dihydropyridine derivative
    Patent number: 6350766
    Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: February 26, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hisayuki Uneyama, Seiji Niwa, Tomoyuki Onishi
  • Dihydropyridine compounds and composition containing the same
    Publication number: 20020002167
    Abstract: A dihydropyridine compound of the formula: 1
    Type: Application
    Filed: April 23, 2001
    Publication date: January 3, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Seiji Niwa, Seiji Ohno, Akira Takahara, Morikazu Kito