Abstract: To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a resin lid member (7) is bonded to the electrode film via a thermoplastic resin layer (10) or an adhesive layer to cover the dissolution liquid passing hole, and a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via the resin lid member (7).

Abstract: To provide an easily producible mass-production type transdermal drug device having a structure that a dissolution liquid and a drug can be mixed by simple operations. The device comprises an electrode holder (1) having an electrode layer (1b) formed on a substrate (1a), a drug-loaded member (2) provided on a surface of the electrode holder (1) for forming the electrode layer (1b), and a dissolution liquid-storing container (5) provided on a surface of the electrode holder (1) for not forming the electrode layer (1b), wherein a dissolution liquid passing hole (8) is formed in the electrode holder (1), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode holder (1) via a lid material (6) covering the dissolution liquid passing hole (8), the dissolution liquid-storing container (5) has a protrusion (5b) opposing the dissolution liquid passing hole (8), and the protrusion (5b) has a recessed surface at the tip.

Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.

Abstract: The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device (5) has, on a microneedle substrate (8), a plurality of microneedles (6) that can pierce the skin, wherein the surface of the microneedles (6) and/or the microneedle substrate (8) is partly or entirely coated in fixed state with a coating carrier containing polyvinyl alcohol. The polyvinyl alcohol preferably has a hydrolysis degree of 94.5 mol % or more. Furthermore, the coating carrier can contain a drug.

Abstract: It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).

Abstract: Provided a patch activated in use capable of uniformly activating a drug by supplying a solution when used. The patch activated in use comprises an absorber 11 containing a dry drug 10 and formed of a material capable of absorbing a liquid, a wall material 13 arranged around the absorber 11 and having an adhesive layer 12 on the lower surface thereof, a support 15 arranged on the absorber 11 and the wall material 13 and having an opening 14 at the center, a diaphragm 20 arranged on the support 15, and a dissolution liquid reservoir 18 arranged on the diaphragm 20, holding a dissolution liquid dissolving the drug in a space with the diaphragm 20 and having a protruding portion 17 which breaks the diaphragm 20 by pressure. The protruding portion 17 has a liner top end portion and arranged in contact or in the proximity with the diaphragm 20. A liner 19 is detachably provided on the lower surface of the absorber 11 and adhesive layer 12.

Abstract: A transdermal drug administration system with microneedles which can perforate the skin (stratum corneum) by a simple operation at the time of transdermal administration of a physiologically active substance (drug) is provided. The present transdermal drug administration system with microneedles comprises microneedle device (50) having a plurality of microneedles (51) which can perforate the skin and a plurality of solution passages (52); absorbent (11) which is disposed on microneedle device (50), comprising dried drug (10) and a material which can absorb liquid; and dissolution liquid reservoir (18) which is disposed on absorbent (11) and stores dissolution liquid (16) for dissolving drug (10) and in which a diaphragm (20) provided between absorbent (11) can be broken by pressing.

Abstract: It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.

Abstract: A hydrogel composition containing as an active ingredient a drug that is transdermally or transmucosally absorbed to produce a drug effect, the hydrogel composition comprising polyvinyl alcohol with a saponification degree of 90-96 mol %, a water-soluble polymer and water, wherein the content of the water-soluble polymer is no greater than 25 wt % and the water content is at least 60 wt %, with respect to the total weight of the hydrogel composition.

Abstract: The present invention provides an adhesive gel composition for iontophoretic formulations which is useful for the application through the skin or the mucosa, which excels in all of drug absorption, drug stability, gel shape retention and gel adhesion, which is easy to prepare and fill at the time of production, and which can be produced at low costs and a method for producing the same. The adhesive gel composition for iontophoretic formulations is produced by mixing an ionic synthetic polymer(s), a nonionic synthetic polymer(s), a naturally-occurring polymer(s), a polyhydric alcohol(s), a crosslinking agent(s) and a drug(s). In the production of the adhesive gel composition for iontophoretic formulations, oxygen dissolved in the gel is positively removed by carrying out replacement with nitrogen and/or vacuum kneading at the time of the ingredients are mixed and kneaded.

Abstract: The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.

Abstract: A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).