Patents by Inventor Seoju Lee

Seoju Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pegylated interleukin-10
    Patent number: 10471126
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: November 12, 2019
    Assignee: Merck Sharp & Dohme Ltd
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Pegylated Interleukin-10
    Publication number: 20180250363
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: February 6, 2018
    Publication date: September 6, 2018
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER
    Publication number: 20180207286
    Abstract: Conjugates of a cholinesterase moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Inventors: Mary J. Bossard, Harold Zappe, Seoju Lee, Lal Ajitha Ratnapala Fernando
  • Pegylated interleukin-10
    Patent number: 9925245
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: March 27, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Pegylated Interleukin-10
    Publication number: 20160166647
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: December 10, 2015
    Publication date: June 16, 2016
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Acid salt forms of polymer-drug conjugates and alkoxylation methods
    Patent number: 9320808
    Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 26, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence
  • Pegylated interleukin-10
    Patent number: 9238079
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: January 19, 2016
    Assignee: Merck Sharp & Dohme Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Salt form of a multi-arm polymer-drug conjugate
    Patent number: 9226969
    Abstract: Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: January 5, 2016
    Assignee: Nektar Therapeutics
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence, Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, David Swallow, John R. Handley, Anthony G. Schaefer
  • ACID SALT FORMS OF POLYMER-DRUG CONJUGATES AND ALKOXYLATION METHODS
    Publication number: 20150105519
    Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
    Type: Application
    Filed: May 21, 2014
    Publication date: April 16, 2015
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence, Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
  • Pegylated Interleukin-10
    Publication number: 20140227223
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 14, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Pegylated interleukin-10
    Patent number: 8697045
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 15, 2014
    Assignee: Merck Sharp & Dohme Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Salt Form of a Multi-Arm Polymer-Drug Conjugate
    Publication number: 20130231359
    Abstract: Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
    Type: Application
    Filed: November 18, 2010
    Publication date: September 5, 2013
    Applicant: Nektar Therapeutics
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence, Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
  • Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods
    Publication number: 20130143909
    Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
    Type: Application
    Filed: November 18, 2010
    Publication date: June 6, 2013
    Applicant: Nektar Therapeutics
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence, Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
  • PEGYLATED INTERLEUKIN-10
    Publication number: 20110305665
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: August 26, 2011
    Publication date: December 15, 2011
    Applicant: Schering Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan Cannon-Carlson
  • Conjugates of a Cholinesterase Moiety and a Polymer
    Publication number: 20110135623
    Abstract: Conjugates of a cholinesterase moiety and one or more nonpeptidic, water soluble polymers are provided. Typically, the nonpeptidic, water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
    Type: Application
    Filed: May 15, 2009
    Publication date: June 9, 2011
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Mary J. Bossard, Harold Zappe, Seoju Lee, Lal Ajitha Ratnapala Fernando
  • Pegylated Interleukin-10
    Publication number: 20110064690
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 17, 2011
    Applicant: Schering Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • PEGYLATED INTERLEUKIN-10
    Publication number: 20100297069
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: November 18, 2009
    Publication date: November 25, 2010
    Applicant: SCHERING CORPORATION
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • PEGYLATED INTERLEUKIN-10
    Publication number: 20080317707
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: August 28, 2008
    Publication date: December 25, 2008
    Applicant: SCHERING CORPORATION
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Methods for quantifying polymer attachment to a particle
    Publication number: 20070122800
    Abstract: The present invention relates to improved methods for quantifying the degree of polymer attachment of particles with multiple polymer attachment sites. The disclosed methods are useful for gene therapy, particularly gene therapy using pegylated adenoviral vectors.
    Type: Application
    Filed: November 21, 2006
    Publication date: May 31, 2007
    Inventors: Seoju Lee, Gary Vellekamp
  • Pegylated interleukin-10
    Publication number: 20060210534
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: May 25, 2006
    Publication date: September 21, 2006
    Inventors: Seoju Lee, David Wylie, Susan Cannon-Carlson