Patents by Inventor Seoju Lee

Seoju Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pegylated interleukin-10
    Patent number: 7052686
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: May 30, 2006
    Assignee: Schering Corporation
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Pegylated interleukin-10
    Publication number: 20020044921
    Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
    Type: Application
    Filed: September 28, 2001
    Publication date: April 18, 2002
    Inventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
  • Methods for conversion of protein isoforms
    Patent number: 6281337
    Abstract: The present invention provides methods for isolating adjunct isoforms of proteins and converting them to the desired protein. In preferred embodiments, the present invention contemplates the use of acid solutions or zinc solutions to cleave a chemical group from a desired protein. In further preferred embodiments, the present invention contemplates the oxidation of reduced sulfhydryl groups with cleavage of chemical groups to form a functional desired protein.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: August 28, 2001
    Assignee: Schering Corporation
    Inventors: Susan Cannon-Carlson, Andres Frei, Seoju Lee, Roland Mengisen, Marcio Voloch, David C. Wylie
  • Substantially pure histidine-linked protein polymer conjugates
    Patent number: 5985263
    Abstract: Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under conditions sufficient to facilitate covalent attachment of at least a portion of the polymer strands on histidine residues of the protein and thereafter substantially separating the histidine-linked conjugates from the remaining reactants.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: November 16, 1999
    Assignee: Enzon, Inc.
    Inventors: Seoju Lee, Charles McNemar