Patents by Inventor Serge Martinez

Serge Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
    Publication number: 20020188007
    Abstract: N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.
    Type: Application
    Filed: June 7, 2002
    Publication date: December 12, 2002
    Inventors: Francis Barth, Philippe Camus, Serge Martinez, Murielle Rinaldi
  • Pyrazolecarboxylic acid derivatives, their preparation, pharmaceutical compositions containing them
    Patent number: 6432984
    Abstract: N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: August 13, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Francis Barth, Philippe Camus, Serge Martinez, Murielle Rinaldi
  • Pyrazole derivatives, method for preparing same, and pharmaceutical compositions containing said derivatives
    Patent number: 6028084
    Abstract: Compounds of formula (I), wherein R.sub.1 is fluorine, hydroxy, (C.sub.1-5) alkoxy, (C.sub.1-5) alkylthio, hydroxy(C.sub.1-5)alkoxy, a -NR.sub.10 R.sub.11, group, cyano, (C.sub.1-5) alkyl-sulphonyl or (C.sub.1-5) alkylsulphinyl; R.sub.2 and R.sub.3 are each (C,.sub.4) alkyl or, taken together with the nitrogen atom to which they are attached, form a saturated or unsaturated 5- to 10-membered heterocyclic radical optionally substituted one or more times by (C.sub.1-3) alkyl or (C.sub.1-3) alkoxy; each of R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 is independently hydrogen, halogen or trifluoromethyl, and when R.sub.1 is fluorine, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and/or R.sub.9 may also be fluoromethyl; with the proviso that at least one of substituents R.sub.4 or R.sub.7. is other than hydrogen; each of R.sub.10 and R.sub.11 is independently hydrogen or (C.sub.1-5) alkyl, or R.sub.10 and R.sub.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: February 22, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi
  • Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present
    Patent number: 5624941
    Abstract: The present invention relates to compounds of the formula: ##STR1## These compounds are useful in pharmaceuticals in which cannabis is known to be involved.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: April 29, 1997
    Assignee: Sanofi
    Inventors: Francis Barth, Pierre Casellas, Christian Congy, Serge Martinez, Murielle Rinaldi, Gilles Anne-Archard
  • Process for preparing N-alkylene piperidino compounds and their enantiomers
    Patent number: 5606065
    Abstract: The invention relates to N-alkylenepiperidino compounds of formula ##STR1## as well as their enantiomers, a process for preparing them and pharmaceutical compositions containing them.These compounds are useful as antagonists of neurokinin receptors in the treatment of substance P- and/or neurokinin-dependent pathologies.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: February 25, 1997
    Assignee: Sanofi
    Inventors: Xavier Emonds-Alt, Serge Martinez, Vincenzo Proietto, Didier Van Broeck
  • Pyrazole-3-carboxamide derivatives, process for their preparation and pharmaceutical compositions in which they are present
    Patent number: 5462960
    Abstract: The present invention relates to novel pyrazole-3-carboxamide derivatives of the formula ##STR1## in which the substituents are as defined in the specification. The present invention further relates to a process for the preparation of these novel derivatives and to the pharmaceutical compositions in which they are present.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: October 31, 1995
    Assignee: Sanofi
    Inventors: Francis Barth, Pierre Casellas, Christian Congy, Serge Martinez, Murielle Rinaldi
  • N-alkylenepiperidino compounds, their enantiomers and pharmaceutical compositions
    Patent number: 5411971
    Abstract: The invention relates to N-alkylenepiperidino compounds of formula ##STR1## as well as their enantiomers, and pharmaceutical compositions containing them that are useful as antagonists of neurokinin receptors in the treatment of substance P- and/or neurokinin-independent pathologies.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: May 2, 1995
    Assignee: Elf Sanofi
    Inventors: Xavier Edmonds-Alt, Serge Martinez, Vincenzo Proietto, Didier Van Broeck