Patents by Inventor Sergio A. Quezada

Sergio A. Quezada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination Immunotherapy for the Treatment of Cancer
    Publication number: 20160244524
    Abstract: Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.
    Type: Application
    Filed: May 3, 2016
    Publication date: August 25, 2016
    Inventors: James Allison, Padmanee Sharma, Sergio A. Quezada, Tihui Fu
  • Combination immunotherapy for the treatment of cancer
    Patent number: 9375475
    Abstract: Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: June 28, 2016
    Assignees: Board of Regents, The University of Texas System, Memorial Sloan-Kettering Cancer Center
    Inventors: James Allison, Padmanee Sharma, Sergio A. Quezada, Tihui Fu
  • Combination Immunotherapy for the Treatment of Cancer
    Publication number: 20140308299
    Abstract: Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 16, 2014
    Inventors: James Allison, Padmanee Sharma, Sergio A. Quezada, Tihui Fu
  • Combination immunotherapy for the treatment of cancer
    Patent number: 8709417
    Abstract: Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: April 29, 2014
    Assignees: Memorial Sloan-Kettering Cancer Center, Board of Regents
    Inventors: James Allison, Padmanee Sharma, Sergio A. Quezada, Tihui Fu
  • REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    Publication number: 20140004537
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF.
    Type: Application
    Filed: May 22, 2013
    Publication date: January 2, 2014
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8465740
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 18, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Combination Immunotherapy for the Treatment of Cancer
    Publication number: 20120251556
    Abstract: Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.
    Type: Application
    Filed: September 30, 2010
    Publication date: October 4, 2012
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: James Allison, Padmanee Sharma, Sergio A. Quezada, Tihui Fu
  • Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity
    Patent number: 8236304
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: August 7, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    Publication number: 20120195894
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF.
    Type: Application
    Filed: December 15, 2011
    Publication date: August 2, 2012
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
    Patent number: 8097249
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: January 17, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Regulatory T Cell Mediator Proteins and Uses Thereof
    Publication number: 20080287358
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNE Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Application
    Filed: April 24, 2006
    Publication date: November 20, 2008
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek