Abstract: A valve repair device includes a pair of anchors and at least one leak inhibitor. The device can also include a spacer or coaptation element. The pair of anchors can be coupled to the spacer or coaptation element. The pair of anchors are movable between an open position and a closed position and are configured to attach the valve repair device to the native valve of the patient. The at least one leak inhibitor extends between the pair of anchors and is configured to inhibit retrograde blood flow through the device, for example, between one or more openings between leaflet portions that are in the anchors.

Abstract: In one example, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. A size of the spacer body is configured to be adjusted after the spacer body is placed between the native valve leaflets and the pair of anchors are placed against the ventricular surfaces of the native heart valve leaflets. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

Abstract: Valve repair devices are disclosed herein. A valve repair device can include a main shaft and a pair of paddles. Each paddle comprises a connection portion, an inner paddle portion, and an outer paddle portion made from a single metal ribbon-like strip. The ribbon-like material of each connection portion of the pair of paddles extends along the main shaft from a distal end of the main shaft toward a proximal end of the main shaft and the connection portion is connected to the main shaft. The pair of paddles are moveable between an open position and a closed position.

Abstract: Prosthetic heart valves including a radially expandable annular frame and valvular structure disposed within the frame, as well as methods and delivery apparatus associated therewith, are disclosed. The frame can include commissure-supporting cells for attachment of commissures of the valvular structure to the frame. The commissure-supporting cells can be offset from an outflow end of the frame by an offset distance and aligned with gaps in the frame. In some examples, the gaps are defined by a row of discontinuous cells in an outflow portion of the frame. In some examples, the gaps are defined by pairs of cells in an outflow portion of the frame. In some examples, the pairs of cells are enlarged relative to other cell of the frame.

Abstract: A catheter assembly includes a handle assembly, a steerable catheter, and an actuation element. The handle assembly includes a handle housing, a guide member, a follower, and a driver. The driver engages the follower to cause the follower to move relative to the guide member. The actuation element is connected to the follower and the steerable catheter. Movement of the follower relative to the guide member causes the actuation element to engage the steerable catheter to move the steerable catheter between the flexed configuration and the unflexed configuration.

Abstract: Valve repair devices are disclosed herein. One valve repair device has a main shaft and a pair of paddles. The pair of paddles include a connection portion, an inner paddle portion, and an outer paddle portion. Each connection portion of the pair of paddles is connected to the main shaft. The pair of paddles are moveable between an open position and a closed position.

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.

Abstract: A valve treatment device having a coaptation element, a first anchor assembly configured to grasp a first leaflet of a native heart valve, and a second anchor assembly configured to grasp a second leaflet of the native heart valve. The first anchor assembly is connected to a first side of the coaptation element. The second anchor assembly is connected to a second side of the coaptation element. The valve treatment device can include a bioabsorbable central portion between the first anchor assembly and the second anchor assembly.

Abstract: A valve repair device includes a first paddle, a second paddle, a spacer, a first gripping member, and a second gripping member. The first paddle and the second paddle are configured to move between a closed position and an open position. The spacer is disposed between the first paddle and the second paddle. The first gripping member is disposed between the first paddle and the spacer. The second gripping member is disposed between the second paddle and the spacer. The first paddle and the first gripping member are configured to capture a first native valve leaflet. The second paddle and the second gripping member are configured to capture a second native valve leaflet.

Abstract: Apparatus, usable with a valve disposed between an atrium and a ventricle of a heart, the valve having a first leaflet (S) and at least one opposing leaflet (A,P). The apparatus comprises an augmenter (700) that comprises a flexible pouch (710) and an anchor (780). The pouch has an external surface, an interior, an outside, and a downstream opening that provides fluid communication between the interior and the outside of the pouch. The anchor is coupled to the pouch, and configured to anchor the pouch to the lip of the first leaflet by the anchor being anchored to the first leaflet. The anchoring is such that the downstream opening opens into the ventricle. Responsively to ventricular systole, the pouch inflates via the downstream opening, and the external surface coapts against the opposing leaflet(s).

Abstract: Medical procedures and devices that use bioimpedance-based feedback are disclosed. Bioimpedance-based feedback can include measuring or acquiring electrical signals that include or indicate a bioimpedance signal. The bioimpedance signal can be used to determine the position and/or status of device (e.g., of a clasp or anchor of the device) and/or tissue near the device. The bioimpedance signal can be analyzed and converted into information presented to a clinician to indicate a status of a portion of a device to provide feedback regarding the position and/or status of the device, for example, anchoring elements of an implant. Some devices enable the removal of electrodes or electrical leads when the device is implanted.

Abstract: An implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. Each anchor is configured to be positioned behind a native valve leaflet of the two native leaflets such that the native leaflet is captured between the anchor and the spacer body.

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.

Abstract: In a method of treating an atrioventricular valve, a sealing element is deployed in a native atrioventricular valve of a heart at a position between native atrioventricular valve leaflets to contact the native atrioventricular valve leaflets. The sealing element is controlled by user input to both radially expand and radially reduce the sealing element while at the position between the native atrioventricular valve leaflets. At least one of the native atrioventricular leaflets is secured between an inner anchor member and an outer anchor member to support the sealing element at a desired position between the native atrioventricular valve leaflets.

Abstract: Valve repair devices and valve repair systems for repairing a native valve of a patient are configured to reduce a gap in the native valve of the patient when the valve repair device is attached to the native valve. The valve repair devices can include a spacer. The valve repair devices can be closes to attach the device to leaflets of the heart valve.

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve.

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The clasps include a fixed arm and a plurality of movable arms. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve.

Abstract: A valve repair device for repairing a native valve of a patient can include a coaptationm element. The valve repair device can include a pair of paddles. The coaption element can comprise a fabric. The pair of paddles can be connected to the coaption element. The paddles are movable between an open position and a closed position. The paddles are configured to attach to the native valve of the patient.

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve. Other embodiments are also described.

Abstract: An device for treating a native valve includes a sealing element and an anchoring element. The sealing element is made from a braided mesh material. The sealing element is dimensioned to be deployed in an annulus of a native valve of a heart at a position between native valve leaflets to contact the native valve leaflets during ventricular systole to create a seal to prevent regurgitation of blood from the left ventricle to the left atrium. The sealing element is configured to both be radially expanded and radially reduced while at the position between the native valve leaflets. The anchoring element is adapted for deployment in the heart, the anchoring element coupled to the sealing element and configured to support the sealing element at the desired position between native valve leaflets.