Abstract: An exemplary valve repair device for repairing a native valve of a patient includes a coaption element, a pair of paddles, and barb portions. The barb portions extend directly from at least one of the coaption element and the pair of paddles.

Abstract: An expandable stent for implantation in a right ventricular outflow tract includes a frame having a plurality of struts that define a repeating pattern of cells. The repeating pattern of cells comprises a column of exactly three generally diamond shaped cells positioned in end-to-end alignment, and a column of exactly two generally diamond shaped cells positioned in end-to-end alignment. The frame has a substantially hourglass shape with a narrow portion in between a proximal end portion and a distal end portion, wherein the proximal end portion and the distal end portion are configured to expand radially outward to contact a right ventricular outflow tract.

Abstract: A valve repair device for repairing a native valve of a patient includes a pair of paddles and a pair of gripping members. The pair of paddles are movable between an open position and a closed position. Each paddle comprises a metal loop that is moveable from a compressed condition where each metal loop has a first width to an expanded condition where each loop has a second width that is greater than the first width. The pair of gripping members are configured to attach to the native valve of the patient.

Abstract: A prosthetic heart valve can include a stent and a leaflet assembly mounted to the stent. The stent is formed by a plurality of struts and includes an inflow end and an outflow end. The stent is deformable from a radially compressed configuration to a radially expanded configuration. The plurality of struts forms a plurality of rows of cells. The plurality of rows of cells includes a row of inflow cells at the inflow end, a row of outflow cells at the outflow end, and a row of intermediate cells that follows the row of outflow cells towards the inflow end. Each inflow cell comprises an inflow free apex. Each outflow cell comprises an outflow free apex and extends along an axial direction of the stent up to an end of said row of intermediate cells that points towards the inflow end of the stent.

Abstract: A valve repair device includes a pair of anchors and at least one leak inhibitor. The device can also include a spacer or coaptation element. The pair of anchors can be coupled to the spacer or coaptation element. The pair of anchors are movable between an open position and a closed position and are configured to attach the valve repair device to the native valve of the patient. The at least one leak inhibitor extends between the pair of anchors and is configured to inhibit retrograde blood flow through the device, for example, between one or more openings between leaflet portions that are in the anchors.

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.

Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The prosthetic valve comprises a frame or stent that comprises multiple cells arranged in unique ways. The prosthetic valve also comprises a leaflet assembly coupled to the frame and having a plurality of leaflets, wherein the leaflets are configured to allow blood to flow through the prosthetic heart valve in one direction from an inflow end portion to an outflow end portion of the frame or stent.

Abstract: Valve repair devices are disclosed herein. One valve repair device has a main shaft and a pair of paddles. The pair of paddles include a connection portion, an inner paddle portion, and an outer paddle portion. Each connection portion of the pair of paddles is connected to the main shaft. The pair of paddles are moveable between an open position and a closed position.

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.

Abstract: Example systems and valve repair devices for repairing a native valve of a patient includes a plurality of paddle portions. The plurality of paddle portions are moveable between an open position and a closed position by moving a cap with respect to a collar. A plurality of paddle frames are connected to the cap and to the paddle portions. A width of the plurality of paddle frames is adjustable during an implantation procedure of the valve repair device.

Abstract: A septal closure and port device for implantation in the atrial septum of a patient's heart comprises an expandable frame can comprise a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further comprise a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart.

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve. Other embodiments are also described.

Abstract: In a method of installing an expandable stent in a right ventricular outflow tract, a frame of the expandable stent is positioned at a deployed position in the right ventricular outflow tract, the frame including a waist portion, and first and second opposed sealing portions extending from the waist portion. The frame is expanded such that the waist portion expands to a first diameter, the first sealing portion expands to a second diameter larger than the first diameter and into contact with a first portion of an inner surface of the right ventricular outflow tract, and the second sealing portion expands to a third diameter larger than the first diameter and into contact with a second portion of the inner surface of the right ventricular outflow tract, wherein the waist portion is spaced apart from the inner surface of the right ventricular outflow tract at the deployed position.

Abstract: An expandable stent for implantation in a right ventricular outflow tract includes a frame having a plurality of struts that define a repeating pattern of cells. The repeating pattern of cells comprises a column of exactly three generally diamond shaped cells positioned in end-to-end alignment, and a column of exactly two generally diamond shaped cells positioned in end-to-end alignment. The frame has a substantially hourglass shape with a narrow portion in between a proximal end portion and a distal end portion, wherein the proximal end portion and the distal end portion are configured to expand radially outward to contact a right ventricular outflow tract.

Abstract: An expandable stent for implantation in a right ventricular outflow tract includes a frame having a waist portion that expands to a deployed size having a first diameter, first and second sealing portions extending in opposite directions from the waist portion and expanding radially outward of the waist portion. The first and second sealing portions are sized to seal against first and second portions of the inner surface of the right ventricular outflow tract at the deployed position over a range of sizes of expansion larger than the first diameter. A band is secured to the waist portion of the frame, restricting expansion of the waist portion substantially beyond the first diameter, such that the waist portion is configured to be spaced apart from the inner surface of the right ventricular outflow tract at the deployed position.

Abstract: An implantable prosthetic device such as might be used to treat poor function of a diseased heart valve in a medical patient includes a body portion and an anchor portion including a plurality of paddles. Clasps attached to the paddles include fixed arms and moveable arms operable to secure the device to the patient's native valve leaflets.

Abstract: A valve repair device for repairing a native heart valve of a patient includes a pair of clasps, a pair of paddles, and a coupler. The clasps and paddles are configured to attach to native valve leaflets of the heart valve. The coupler is mechanically connected to the paddles. The coupler is configured to move the paddles between a partially open position and a closed position. The coupler is configured to move freely such that ends of the pair of paddles move away from one another when the native valve leaflets open during a diastolic phase of a cardiac cycle and the ends of the pair of paddles move toward one another when the native valve leaflets close during a ventricular systole of the cardiac cycle.

Abstract: An device for treating a native valve includes a sealing element and an anchoring element. The sealing element is made from a braided mesh material. The sealing element is dimensioned to be deployed in an annulus of a native valve of a heart at a position between native valve leaflets to contact the native valve leaflets during ventricular systole to create a seal to prevent regurgitation of blood from the left ventricle to the left atrium. The sealing element is configured to both be radially expanded and radially reduced while at the position between the native valve leaflets. The anchoring element is adapted for deployment in the heart, the anchoring element coupled to the sealing element and configured to support the sealing element at the desired position between native valve leaflets.

Abstract: A system for implanting a repair device onto a native valve of a natural heart to repair the native valve of a patient during a non-open-heart procedure. The system includes a surgical a valve repair device for repairing a native valve of a patient including a pair of paddles, and a pair of gripping members. The paddles are movable between an open position and a closed position, in which the paddles are moved to the open position by moving a pivot point of each paddle in an outward direction and pivoting each of the paddles about the pivot point of the paddle. The paddles and the gripping members are configured to attach to the native valve of the patient when the paddles are in the closed position.