Patents by Inventor Sha Wang

Sha Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220126286
    Abstract: An nucleic acid integrated detection reagent tube is provided, it includes a main tube and one or more branch tubes, wherein a lysing zone, a cleaning zone and a plurality of separation plugs comprising at least a least a separation plug and a second separation plug which are sequentially disposed, the first separation plug is used for separating the lysing zone and the cleaning zone, a reaction zone is provided in the branch tubes and the second separation plug is positioned at a connection between the branch tubes and the main tube or inside the branch tubes; hydrophobic layers in a liquid or a solid phase disposed at each of the plurality of separation plugs; and a magnetic bead channel for magnetically carrying the nucleic acid to sequentially pass through each hydrophobic layer penetrating to the branch tubes defined in an inner wall of the detection reagent tube.
    Type: Application
    Filed: December 30, 2021
    Publication date: April 28, 2022
    Applicant: USTAR Biotechnologies (Hangzhou) Ltd.
    Inventors: Qimin YOU, Lin HU, Chen QI, Junwei YU, Zhujun YU, Sha WANG, Rongyu JIN, Daisang WANG, Sisi CHEN, Junli HE, Jing CHEN, Huanxin RAO, Yanqiong ZHOU, Fan YANG
  • Publication number: 20220119863
    Abstract: An nucleic acid integrated detection method is provided, the method includes separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube.
    Type: Application
    Filed: December 30, 2021
    Publication date: April 21, 2022
    Applicant: USTAR Biotechnologies (Hangzhou) Ltd.
    Inventors: Qimin YOU, Lin HU, Chen QI, Junwei YU, Zhujun YU, Sha WANG, Rongyu JIN, Daisang WANG, Sisi CHEN, Junli HE, Jing CHEN, Huanxin RAO, Yanqiong ZHOU, Fan YANG
  • Publication number: 20220098791
    Abstract: An experimental system for studying a refining mechanism and characteristic of a refiner plate, including a disc refiner unit, a first storage tank, a second storage tank, a circulating pump, a pipeline system, a detection device for measuring process variables including flow, pressure and temperature, and a data acquisition and control system. An operation parameter control system is provided to control an operation state of valves at different positions of the pipeline system to achieve the switching of the operation mode of the experimental system. The data acquisition and control system is configured to collect the parameters at different detection points. A method for operating the experimental system is also provided.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Inventors: Jixian DONG, Huan LIU, Bo WANG, Chuanwu DUAN, Kai QI, Xiya GUO, Lijie QIAO, Sha WANG
  • Patent number: 11272533
    Abstract: Provided are a random-access sending and receiving method and apparatus, transmitting end, receiving end, and storage medium. The random-access sending method includes: a preamble resource is acquired, and preamble information is generated; a pilot resource is determined according to the preamble resource and a user equipment identifier, and pilot information is generated; data information is acquired, and the data information is mapped to a time-frequency resource, the data information including user equipment identifier information; and a radio frame is formed from the preamble information, the pilot information and the data information, and the radio frame is sent.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: March 8, 2022
    Assignee: XI'AN ZHONGXING NEW SOFTWARE CO., LTD.
    Inventors: Wei Cao, Li Tian, Wuchen Jiao, Tao Lu, Sha Wang
  • Patent number: 11242552
    Abstract: A nucleic acid integrated detection method and detection reagent tube are provided, separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: February 8, 2022
    Assignee: USTAR Biotechnologies (Hangzhou) Ltd.
    Inventors: Qimin You, Lin Hu, Chen Qi, Junwei Yu, Zhujun Yu, Sha Wang, Rongyu Jin, Daisang Wang, Sisi Chen, Junli He, Jing Chen, Huanxin Rao, Yanqiong Zhou, Fan Yang
  • Patent number: 11090715
    Abstract: The present invention discloses a method for designing a refiner plate with equidistant curved bars, comprising following steps of: designing a central bar are of center curved bar and defining the bar angle for the equidistant curved bar; designing circle arcs for curved bars on two sides of center curved bar of equidistant curved bar segment; when the whole refining segment is full of circle arcs, trimming lines of outer circle arcs of the refining segment to complete the design of equidistant circle arcs on the two sides; and if required, dividing the bars into zones. In the present invention, by the definition of the bar angle for the curved bars and the parametric design of the equidistant curved bars by using circle are equations, it is ensured that the flexibility in designing an equidistant curved bar refiner plate is improved.
    Type: Grant
    Filed: September 21, 2019
    Date of Patent: August 17, 2021
    Assignee: Shaanxi University of Science & Technology
    Inventors: Jixian Dong, Huan Liu, Xiya Guo, Bo Wang, Dong Wang, Hui Jing, Sha Wang, Ruifan Yang
  • Publication number: 20210155974
    Abstract: A nucleic acid integrated detection method and detection reagent tube are provided, separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube.
    Type: Application
    Filed: February 1, 2019
    Publication date: May 27, 2021
    Applicant: USTAR Biotechnologies (Hangzhou) Ltd.
    Inventors: Qimin YOU, Lin HU, Chen QI, Junwei YU, Zhujun YU, Sha WANG, Rongyu JIN, Daisang WANG, Sisi CHEN, Junli HE, Jing CHEN, Huanxin RAO, Yanqiong ZHOU, Fan YANG
  • Publication number: 20210087632
    Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
    Type: Application
    Filed: October 8, 2019
    Publication date: March 25, 2021
    Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
  • Publication number: 20200383138
    Abstract: Provided are a random-access sending and receiving method and apparatus, transmitting end, receiving end, and storage medium. The random-access sending method includes: a preamble resource is acquired, and preamble information is generated; a pilot resource is determined according to the preamble resource and a user equipment identifier, and pilot information is generated; data information is acquired, and the data information is mapped to a time-frequency resource, the data information including user equipment identifier information; and a radio frame is formed from the preamble information, the pilot information and the data information, and the radio frame is sent.
    Type: Application
    Filed: March 2, 2018
    Publication date: December 3, 2020
    Inventors: Wei CAO, Li TIAN, Wuchen JIAO, Tao LU, Sha WANG
  • Publication number: 20200358499
    Abstract: A method and apparatus for generating and utilizing spreading sequence codebooks for a symbol-level sequence spreading is disclosed. In one embodiment, a method performed by a wireless communication device, comprising: receiving a first number from a wireless communication node; selecting a first spreading sequence codebook from at least one spreading sequence codebook; selecting a first spreading sequence from the first spreading sequence codebook according to the first number; and spreading data symbols according to the first spreading sequence, wherein the at least one spreading sequence codebook each comprises a plurality of spreading sequences configured based on one entry of a first sequence set after cyclic shifting operation, wherein the first sequence set before cyclic shifting operation is configured based on a second sequence set.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 12, 2020
    Inventors: Sha WANG, Yifei YUAN, Li TIAN, Zhifeng YUAN, Wei CAO
  • Publication number: 20200322994
    Abstract: Optimizing the resource configuration or selection for grant-free contention-based non-orthogonal multiple access (NOMA) transmissions is an effective way to increase network capacity and reduce multi-user interference at the user equipment (UE). In some embodiments, a network node may determine the current traffic load, select multiple access (MA) sequences for the UE based on the determination, and transmit this selection to the UE for subsequent transmissions. In other embodiments, the UE may receive a message with an indication of the traffic load being experienced by the base station that the UE is attempting to connect to, and then may randomly select an MA sequence for subsequent transmissions.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Inventors: Li Tian, Wei Cao, Sha Wang, Yifei Yuan, Zhifeng Yuan
  • Publication number: 20200130055
    Abstract: The present invention discloses a method for designing a refiner plate with equidistant curved bars, comprising following steps of: designing a central bar are of center curved bar and defining the bar angle for the equidistant curved bar; designing circle arcs for curved bars on two sides of center curved bar of equidistant curved bar segment; when the whole refining segment is full of circle arcs, trimming lines of outer circle arcs of the refining segment to complete the design of equidistant circle arcs on the two sides; and if required, dividing the bars into zones. In the present invention, by the definition of the bar angle for the curved bars and the parametric design of the equidistant curved bars by using circle are equations, it is ensured that the flexibility in designing an equidistant curved bar refiner plate is improved.
    Type: Application
    Filed: September 21, 2019
    Publication date: April 30, 2020
    Inventors: Jixian DONG, Huan LIU, Xiya GUO, Bo WANG, Dong WANG, Hui JING, Sha WANG, Ruifan YANG
  • Publication number: 20200129985
    Abstract: The present invention discloses a method for designing a refiner plate with three-stage radial curved bars, comprising following steps of: designing a circle arc for 1st stage radial curved bars; designing a circle arc for the 2nd stage radial curved bars; designing a circle arc for 3rd stage radial curved bars; and designing a center angle for the refiner plate according to the size of the refiner plate and the manufacture requirements, to complete the design of the refiner plate. In the present invention, by the establishment of equations for the circle arcs and angles of inclination of the curved bars, it is ensured that the width of the bars will not change in the radial direction, and both the flexibility in designing a curved refiner plate and the uniformity of crushing are improved. This design method provides a theory basis and also instructions for designing multi-stage radial curved bars.
    Type: Application
    Filed: September 20, 2019
    Publication date: April 30, 2020
    Inventors: Jixian DONG, Huan LIU, Xiya GUO, Bo WANG, Dong WANG, Hui JING, Sha WANG, Ruifan YANG
  • Patent number: 10443099
    Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 15, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
  • Publication number: 20190256893
    Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
  • Patent number: 10323267
    Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: June 18, 2019
    Assignee: Becton Dickinson and Company
    Inventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
  • Patent number: 10190152
    Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: January 29, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
  • Patent number: 9499858
    Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 22, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: James G. Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
  • Publication number: 20160194687
    Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.
    Type: Application
    Filed: March 11, 2016
    Publication date: July 7, 2016
    Applicant: Becton, Dickinson and Company
    Inventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
  • Publication number: 20160168638
    Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
    Type: Application
    Filed: September 10, 2015
    Publication date: June 16, 2016
    Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford