Patents by Inventor Sha Wang
Sha Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210087632Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.Type: ApplicationFiled: October 8, 2019Publication date: March 25, 2021Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
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Publication number: 20200383138Abstract: Provided are a random-access sending and receiving method and apparatus, transmitting end, receiving end, and storage medium. The random-access sending method includes: a preamble resource is acquired, and preamble information is generated; a pilot resource is determined according to the preamble resource and a user equipment identifier, and pilot information is generated; data information is acquired, and the data information is mapped to a time-frequency resource, the data information including user equipment identifier information; and a radio frame is formed from the preamble information, the pilot information and the data information, and the radio frame is sent.Type: ApplicationFiled: March 2, 2018Publication date: December 3, 2020Inventors: Wei CAO, Li TIAN, Wuchen JIAO, Tao LU, Sha WANG
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Publication number: 20200358499Abstract: A method and apparatus for generating and utilizing spreading sequence codebooks for a symbol-level sequence spreading is disclosed. In one embodiment, a method performed by a wireless communication device, comprising: receiving a first number from a wireless communication node; selecting a first spreading sequence codebook from at least one spreading sequence codebook; selecting a first spreading sequence from the first spreading sequence codebook according to the first number; and spreading data symbols according to the first spreading sequence, wherein the at least one spreading sequence codebook each comprises a plurality of spreading sequences configured based on one entry of a first sequence set after cyclic shifting operation, wherein the first sequence set before cyclic shifting operation is configured based on a second sequence set.Type: ApplicationFiled: July 28, 2020Publication date: November 12, 2020Inventors: Sha WANG, Yifei YUAN, Li TIAN, Zhifeng YUAN, Wei CAO
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Publication number: 20200322994Abstract: Optimizing the resource configuration or selection for grant-free contention-based non-orthogonal multiple access (NOMA) transmissions is an effective way to increase network capacity and reduce multi-user interference at the user equipment (UE). In some embodiments, a network node may determine the current traffic load, select multiple access (MA) sequences for the UE based on the determination, and transmit this selection to the UE for subsequent transmissions. In other embodiments, the UE may receive a message with an indication of the traffic load being experienced by the base station that the UE is attempting to connect to, and then may randomly select an MA sequence for subsequent transmissions.Type: ApplicationFiled: June 22, 2020Publication date: October 8, 2020Inventors: Li Tian, Wei Cao, Sha Wang, Yifei Yuan, Zhifeng Yuan
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Publication number: 20200129985Abstract: The present invention discloses a method for designing a refiner plate with three-stage radial curved bars, comprising following steps of: designing a circle arc for 1st stage radial curved bars; designing a circle arc for the 2nd stage radial curved bars; designing a circle arc for 3rd stage radial curved bars; and designing a center angle for the refiner plate according to the size of the refiner plate and the manufacture requirements, to complete the design of the refiner plate. In the present invention, by the establishment of equations for the circle arcs and angles of inclination of the curved bars, it is ensured that the width of the bars will not change in the radial direction, and both the flexibility in designing a curved refiner plate and the uniformity of crushing are improved. This design method provides a theory basis and also instructions for designing multi-stage radial curved bars.Type: ApplicationFiled: September 20, 2019Publication date: April 30, 2020Inventors: Jixian DONG, Huan LIU, Xiya GUO, Bo WANG, Dong WANG, Hui JING, Sha WANG, Ruifan YANG
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Publication number: 20200130055Abstract: The present invention discloses a method for designing a refiner plate with equidistant curved bars, comprising following steps of: designing a central bar are of center curved bar and defining the bar angle for the equidistant curved bar; designing circle arcs for curved bars on two sides of center curved bar of equidistant curved bar segment; when the whole refining segment is full of circle arcs, trimming lines of outer circle arcs of the refining segment to complete the design of equidistant circle arcs on the two sides; and if required, dividing the bars into zones. In the present invention, by the definition of the bar angle for the curved bars and the parametric design of the equidistant curved bars by using circle are equations, it is ensured that the flexibility in designing an equidistant curved bar refiner plate is improved.Type: ApplicationFiled: September 21, 2019Publication date: April 30, 2020Inventors: Jixian DONG, Huan LIU, Xiya GUO, Bo WANG, Dong WANG, Hui JING, Sha WANG, Ruifan YANG
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Patent number: 10443099Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.Type: GrantFiled: September 10, 2015Date of Patent: October 15, 2019Assignee: Becton, Dickinson and CompanyInventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
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Publication number: 20190256893Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.Type: ApplicationFiled: April 30, 2019Publication date: August 22, 2019Inventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
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Patent number: 10323267Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.Type: GrantFiled: March 11, 2016Date of Patent: June 18, 2019Assignee: Becton Dickinson and CompanyInventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
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Patent number: 10190152Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.Type: GrantFiled: September 2, 2010Date of Patent: January 29, 2019Assignee: Becton, Dickinson and CompanyInventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
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Patent number: 9499858Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: GrantFiled: January 11, 2013Date of Patent: November 22, 2016Assignee: Becton, Dickinson and CompanyInventors: James G. Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Publication number: 20160194687Abstract: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.Type: ApplicationFiled: March 11, 2016Publication date: July 7, 2016Applicant: Becton, Dickinson and CompanyInventors: Feng Yang, Sha-Sha Wang, Laurence Michael Vaughan, Michael Porter, Elaine Rose
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Publication number: 20160168638Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.Type: ApplicationFiled: September 10, 2015Publication date: June 16, 2016Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
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Publication number: 20150152473Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: ApplicationFiled: January 11, 2013Publication date: June 4, 2015Applicant: BECTON, DICKINSON AND COMPANYInventors: James G. Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Publication number: 20140312216Abstract: A system and removing noise from a mass spectrometer signal for fraction collection is described herein.Type: ApplicationFiled: April 17, 2013Publication date: October 23, 2014Inventors: Simon Prosser, Ben Trumbore, Sha Wang, Nigel Sousou
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Publication number: 20140141435Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.Type: ApplicationFiled: August 12, 2013Publication date: May 22, 2014Applicant: Beckton, Dickinson and CompanyInventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford
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Patent number: 8372605Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: GrantFiled: March 25, 2011Date of Patent: February 12, 2013Assignee: Becton, Dickinson and CompanyInventors: James Nadeau, Tobin J. Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Patent number: 8323929Abstract: The invention employs an unlabeled signal primer comprising a 5? adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3? end of which hybridizes to the complement of the 5? adapter sequence of the signal primer to produce a 5? overhang. Polymerase is used to fill in the overhang and synthesize the complement of the 5? overhang of the reporter probe. Synthesis of the reporter probe complement is detected, either directly or indirectly, as an indication of the presence of the target.Type: GrantFiled: April 7, 2009Date of Patent: December 4, 2012Assignee: Becton, Dickinson and CompanyInventors: Sha-Sha Wang, Keith Thornton, James G. Nadeau, Tobin J. Hellyer
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Publication number: 20110244457Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: ApplicationFiled: March 25, 2011Publication date: October 6, 2011Applicant: Becton, Dickinson and CompanyInventors: James Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha Sha Wang, Keith Thornton
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Publication number: 20110105350Abstract: Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.Type: ApplicationFiled: May 7, 2010Publication date: May 5, 2011Inventors: James A. Garrett, Sha-Sha Wang, Keith Thornton, Richard L. Moore, William Keating, William A. Nussbaumer, Craig C. Whiteford