Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    Publication number: 20040116620
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Application
    Filed: July 30, 2003
    Publication date: June 17, 2004
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Segmented copolyesters as compliant, absorbable coatings and sealants for vascular devices
    Publication number: 20040109892
    Abstract: Disclosed are absorbable sealants or coatings for biomedical devices which are formulated from a segmented copolyester having a molecular weight of more than 5 kDa, a glass transition temperature of less than 35° C., and low degree of crystallinity evidenced by a heat of fusion of less than 25 J/g.
    Type: Application
    Filed: October 24, 2003
    Publication date: June 10, 2004
    Inventor: Shalaby W. Shalaby
  • Polyester/cyanoacrylate tissue adhesive formulations
    Patent number: 6723114
    Abstract: The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: April 20, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Absorbable &egr;-caprolactone copolymers
    Patent number: 6703035
    Abstract: This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 9, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Cyanoacrylate-capped heterochain polymers and tissue adhesives and sealants therefrom
    Patent number: 6699940
    Abstract: The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: March 2, 2004
    Assignee: Poly Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    Publication number: 20040024169
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 5, 2004
    Inventors: Shalaby W. Shalaby, Dan Akerfeldt, Fredrik Preiniz, Per Egnelov, Torbjorn Mathisen
  • Antimicrobial fabrics
    Publication number: 20030211794
    Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
    Type: Application
    Filed: June 3, 2003
    Publication date: November 13, 2003
    Inventor: Shalaby W. Shalaby
  • Drug-polymer coated stents with segmented homochain copolyesters
    Publication number: 20030199964
    Abstract: The present invention provides a system for treating a vascular condition, including a catheter, a stent coupled to the catheter, a polymeric coating on the stent including a segmented homochain copolyester, and a bioactive drug dispersed within the polymeric coating.
    Type: Application
    Filed: March 20, 2003
    Publication date: October 23, 2003
    Inventors: Shalaby W. Shalaby, Todd Campbell
  • Conjugated drug-polymer coated stent
    Publication number: 20030190341
    Abstract: One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one conjugated drug. Each conjugated drug includes a control agent and a bioactive agent, where the control agent controls the elution rate of the bioactive agent.
    Type: Application
    Filed: April 3, 2002
    Publication date: October 9, 2003
    Inventors: Shalaby W. Shalaby, Todd Campbell
  • Interlinked solid polyethylene glycols and copolymers thereof
    Publication number: 20030162940
    Abstract: The present invention is directed primarily to an interlinked crystalline solid polyethylene glycol composition (I-PEG) having a molecular weight of at least 20 kDa and a melting temperature of at least 40° C. and its use as an absorbable device having hydrolabile ester or carbonate interlinks that allow in vivo dissociation of the interlinked chain into excretable, low molecular weight PEG segments.
    Type: Application
    Filed: February 27, 2003
    Publication date: August 28, 2003
    Inventor: Shalaby W. Shalaby
  • Absorbable E-caprolactone polymers and medical devices
    Publication number: 20030152546
    Abstract: Crystalline, low melting &egr;-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked tonically or covalently to the ester chain which induces autocatalyzed hydrolysis.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 14, 2003
    Inventor: Shalaby W. Shalaby
  • Antimicrobial fabrics
    Patent number: 6596657
    Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 22, 2003
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Bioactive absorbable microparticles as therapeutic vaccines
    Publication number: 20030124149
    Abstract: A therapeutic vaccine for tumor immunotherapy is disclosed which comprises absorbable microparticles/nanoparticles capable of delivering immobilized stimulatory/costimulatory signals and releasing necessary cytokines to promote an anti-tumor effect. The microparticles/nanoparticles are formed of an absorbable crystalline polymer, preferably acid-terminated polyglycolide. Other bioactive agents such as tumor specific antigens, DNA or RNA may be immobilized of the surface of the particles.
    Type: Application
    Filed: July 8, 2002
    Publication date: July 3, 2003
    Inventors: Shalaby W. Shalaby, Waleed S.W. Shalaby, Edward Y. Woo, Heidi Yeh, Carl H. June
  • Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
    Publication number: 20030120029
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Application
    Filed: October 31, 2002
    Publication date: June 26, 2003
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Cyanoacrylate-capped heterochain polymers and tissue adhesives and sealants therefrom
    Publication number: 20030105256
    Abstract: The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.
    Type: Application
    Filed: November 20, 2002
    Publication date: June 5, 2003
    Inventor: Shalaby W. Shalaby
  • Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides
    Publication number: 20030092800
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Application
    Filed: September 20, 2002
    Publication date: May 15, 2003
    Applicant: Biomeasure, Inc.
    Inventors: Shalaby W. Shalaby, Steven A. Jackson, Francis X. Ignatious, Jacques-Pierre Moreau, Ruth M. Russell
  • Phosphonylated derivatives of aliphatic heterochain and acrylate polymers and applications thereof
    Patent number: 6551580
    Abstract: A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are present in an amount of at least about 0.1 percent by weight in each polymeric composition.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: April 22, 2003
    Inventor: Shalaby W. Shalaby
  • Multifaceted compositions for post-surgical adhesion prevention
    Patent number: 6551610
    Abstract: This invention deals with an absorbable, gel-forming composition for multifaceted prevention of post-operative surgical adhesion through a plurality of physico-pharmacological modes, comprising a solution of one or more bioactive compounds in a liquid copolymeric vehicle made by end-grafting one or more cyclic monomer onto a polyalkylene glycol. More specifically, the bioactive drugs can display one or more pharmacological activity associated with antiangiogenic, antineoplastic, anti-inflammatory, and anti-proliferative effects.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: April 22, 2003
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Waleed S. W. Shalaby, Marc Shalaby
  • Stabilized polyester/cyanoacrylate tissue adhesive formulation
    Publication number: 20030069535
    Abstract: The present invention is directed to adhesive/hemostatic formulations of 2-alkoxyalkyl cyanoacrylate, an absorbable liquid or solid polymeric modifier, and a general stabilizer against premature anionic polymerization of cyanoacrylates. The present adhesive formulations are useful as tissue adhesives/sealants, hemostatic agents, or as a means of patching and anastomotic coupling of damaged organs.
    Type: Application
    Filed: November 20, 2002
    Publication date: April 10, 2003
    Inventor: Shalaby W. Shalaby
  • Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof
    Patent number: 6503991
    Abstract: The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or &egr;-caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: January 7, 2003
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby