Patents by Inventor Shalaby W. Shalaby

Shalaby W. Shalaby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiopaque iodinated and iodide-containing crystalline absorbable aliphatic polymeric materials and applications thereof
    Publication number: 20110245912
    Abstract: Radiopaque, iodinated, absorbable polyesters, polyester urethanes, and polyether-ester-urethanes with and without inorganic iodide micro-/nanoparticles dispersed or solubilized therein, and composite inorganic iodide micro-/nanoparticles in an absorbable polyester, polyester-urethane, polyester-ester, or polyether-ester urethane matrix are employed in medical devices and therapeutic compositions.
    Type: Application
    Filed: April 6, 2010
    Publication date: October 6, 2011
    Inventors: Shalaby W. Shalaby, Kenneth David Gray
  • Antimicrobial, radiopaque, microfiber-reinforced, polymeric methacrylate bone cement
    Patent number: 7981945
    Abstract: An methacrylate bone cement is toughened and rendered radiopaque by reinforcing with electrospun microfibers including a radiopacifier and antimicrobial agents to provide a bone cement for use in repairing bone or other hard tissues.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: July 19, 2011
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Michael Scott Taylor
  • Self-primed fabric in self-reinforced polyethylene composites
    Publication number: 20110117352
    Abstract: A self-reinforced polyethylene composite includes a self-primed fabric reinforcement, such as a warp-knitted mesh, and has a fabric/matrix weight ratio of 10/90 to 45/55. Prior to inclusion in the composite the fabric reinforcement is self-primed by dipping in a polyethylene priming solution. The composite is derived from pre-formed sheets stacked in different patterns which yield upon compression molding into composite devices with variable thickness and degrees of mechanical properties. The primer may contain one or more additives to impart certain properties to the final composite.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 19, 2011
    Inventors: Shalaby W. Shalaby, Shawn Peniston
  • BIOSTABLE, MULTIPURPOSE, MICROBICIDAL INTRAVAGINAL DEVICES
    Publication number: 20100330138
    Abstract: Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.
    Type: Application
    Filed: May 11, 2009
    Publication date: December 30, 2010
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas
  • Tissue protecting spray-on copolymeric film composition
    Patent number: 7842749
    Abstract: This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: November 30, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M. Lindsey, III
  • Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof
    Patent number: 7820289
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 26, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kimberly A Carpenter, Kenneth W Clinkscales
  • Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions
    Publication number: 20100256081
    Abstract: Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Application
    Filed: April 5, 2010
    Publication date: October 7, 2010
    Inventors: Shalaby W. Shalaby, Kenneth David Gray, Georgios T. Hilas
  • Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions
    Publication number: 20100255016
    Abstract: Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Application
    Filed: April 5, 2010
    Publication date: October 7, 2010
    Inventors: Shalaby W. Shalaby, David Ingram, Georgios T. Hilas, Sheila Nagatomi
  • Method for radiochemical sterilization
    Patent number: 7771651
    Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: August 10, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • METHOD FOR RADIOCHEMICAL STERILIZATION
    Publication number: 20100196196
    Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 5, 2010
    Inventor: Shalaby W. Shalaby
  • Antimicrobial, Radiopaque, Microfiber-Reinforced, Polymeric Methacrylate Bone Cement
    Publication number: 20100152319
    Abstract: An methacrylate bone cement is toughened and rendered radiopaque by reinforcing with electrospun microfibers including a radiopacifier and antimicrobial agents to provide a bone cement for use in repairing bone or other hard tissues.
    Type: Application
    Filed: February 6, 2007
    Publication date: June 17, 2010
    Inventors: Shalaby W. Shalaby, Michael Scott Taylor
  • Micromantled drug-eluting stent
    Patent number: 7722914
    Abstract: Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: May 25, 2010
    Assignee: Poly-Med, Inc
    Inventor: Shalaby W. Shalaby
  • Radiation and radiochemically sterilized absorbable devices with dose-controlled functional strength retention
    Patent number: 7709556
    Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: May 4, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Package components for radiochemical sterilization
    Patent number: 7694813
    Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: April 13, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Package components for radiochemical sterilization
    Patent number: 7694815
    Abstract: Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 13, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Absorbable, permeability-modulated barrier composites and applications thereof
    Publication number: 20100074941
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Application
    Filed: September 24, 2008
    Publication date: March 25, 2010
    Inventor: Shalaby W. Shalaby
  • Intravaginal Ringed Mesh Device And Applicator Therefor
    Publication number: 20100062039
    Abstract: This invention generally covers a ringed-mesh intravaginal device and applicator therefore wherein the ringed-mesh comprises a composite ring comprising a flexible matrix containing one or more bioactive agent or agents and needed excipients or modulators, and the said matrix is reinforced with a fibrous construct to provided needed initial and in-use biomechanical stability. Of special application of the medicated, ringed-mesh is its use for securing contraception relying on biomechanical, pharmacological, and biochemical means.
    Type: Application
    Filed: December 14, 2005
    Publication date: March 11, 2010
    Inventor: Shalaby W. Shalaby
  • Hydroswellable, segmented, aliphatic polyurethane ureas and intra-articular devices therefrom
    Publication number: 20100056646
    Abstract: Hydroswellable, non-absorbable, biostable, segmented, aliphatic polyether-urethane-ureas or polyether-siloxane-urethane-ureas form a single component, intra-articular device for restoring joints with artificial cartilage, as a cartilage substitute for degenerated cartilage and/or for enhancing the remaining cartilage of an arthritic joint. The intra-articular devices can be bicomponent in nature comprising a biostable, articulating, non-absorbable component and an absorbable component in the form of a solid or microporous liner interfacing with the tissue of defective or diseased joint to support in situ tissue engineering. One or more bioactive agent with specific pharmacological function can be incorporated in the single or bicomponent intra-articular devices to supplement their structural functions.
    Type: Application
    Filed: September 28, 2009
    Publication date: March 4, 2010
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas
  • Film-forming liquid formulations for controlled release of pesticides
    Publication number: 20090318393
    Abstract: A controlled pesticide delivery system includes a film-forming alkanol solution of at least one amphiphilic polymer and at least one pesticide composition for the treatment of at least one pest in gardens, landscapes, forests, and wooden structures, targeting at least one pest selected from fire ants, tent caterpillars, gypsy moths, wood-boring beetles, and bark beetles during at least one phase of their life cycles.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 24, 2009
    Inventor: Shalaby W. Shalaby
  • Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof
    Patent number: 7632765
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 15, 2009
    Assignee: Poly - Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth W Clinkscales, Kimberly A. Carpenter