Abstract: The present disclosure generally relates to fluorescent light energy system and to methods of using such systems in the modulation of inflammatory response, in particular in inflammatory response associated with healing, and for modulation of a treatment regimen for promoting healing of a wound or a condition of the skin and/or soft tissue.

Abstract: The present disclosure generally relates to compositions and methods for modulating mitochondrial dynamic and function in skin conditions.

Abstract: The present disclosure generally relates to silicone-coated biophotonic material and to articles comprising same as well as to the potential uses thereof, such as, for example, in wound treatment.

Abstract: The present technology relates to a biophotonic system comprising at least one chromofilm; and a light-emitting support operably connectable to the chromofilm. Operable connection of the light-emitting support and the at least one chromofilm allows for the light-emitting support to illuminate the at least one chromofilm.

Abstract: A monitoring system is disclosed for in vivo monitoring of preselected physiological parameters associated with acute and/or chronic tissue compromise or failure in one or multiple tissue/organ sites in real time. In one method, a body portion of a surgical stapling device is positioned adjacent a first tissue section, an anvil assembly adapted to engage the body portion is positioned adjacent a second tissue section, and a monitoring device is positioned adjacent the first and/or second tissue sections. The monitoring device includes a sensor adapted to measure a preselected physiological parameter and a transmitter for transmitting signal to an extracorporeal receiving unit. The surgical stapling device is fired to mechanically secure the first and second tissue sections with at least one staple and the preselected physiological parameter is monitored via the information transmitted from the monitoring device to the receiving unit.

Abstract: A monitoring system is disclosed for in vivo monitoring of preselected physiological parameters associated with acute and/or chronic tissue compromise or failure in one or multiple tissue/organ sites in real time. In one method, a body portion of a surgical stapling device is positioned adjacent a first tissue section, an anvil assembly adapted to engage the body portion is positioned adjacent a second tissue section, and a monitoring device is positioned adjacent the first and/or second tissue sections. The monitoring device includes a sensor adapted to measure a preselected physiological parameter and a transmitter for transmitting signal to an extracorporeal receiving unit. The surgical stapling device is fired to mechanically secure the first and second tissue sections with at least one staple and the preselected physiological parameter is monitored via the information transmitted from the monitoring device to the receiving unit.

Abstract: Systems and methods are disclosed herein for maintaining the calibration of non-invasive blood pressure monitoring devices. Phase components of pulse signals detected by the blood pressure monitoring device are compared to stored baseline phase component values. If the difference exceeds a threshold, the blood pressure monitoring device is recalibrated.

Abstract: A monitoring system is disclosed for in vivo monitoring of preselected physiological parameters associated with acute and/or chronic tissue compromise or failure in one or multiple tissue/organ sites in real time. In one method, a body portion of a surgical stapling device is positioned adjacent a first tissue section, an anvil assembly adapted to engage the body portion is positioned adjacent a second tissue section, and a monitoring device is positioned adjacent the first and/or second tissue sections. The monitoring device includes a sensor adapted to measure a preselected physiological parameter and a transmitter for transmitting signal to an extracorporeal receiving unit. The surgical stapling device is fired to mechanically secure the first and second tissue sections with at least one staple and the preselected physiological parameter is monitored via the information transmitted from the monitoring device to the receiving unit.

Abstract: A method and system for separating noise from speech in real time is provided to improve intelligibility of speech for a variety of communications devices and hearing aids. From a speech signal, a plurality of frame-level features are extracted and form the input to the classifier. The classifier is a deep neural network comprising multiple hidden layers and an output layer with multiple output units. The classifier classifies the speech into a plurality of time-frequency units simultaneously. The classifier output constitutes an estimated ideal binary mask from which a fast gammatone filter bank is used to resynthesize the separated speech into an enhanced speech waveform.

Abstract: Embodiments of the present disclosure relate to a system and method for determining a likelihood of successful ventilator weaning for a patient undergoing mechanical or assisted ventilation. Specifically, embodiments provided herein include methods and systems for determining or predicting weaning readiness in a patient based on physiological parameters determined via photoplethysmography.

Abstract: Embodiments disclosed herein may include systems and methods for determining a patient's respiratory effort and blood oxygen saturation based on data acquired from a pulse oximetry sensor and analyzing the parameters in conjunction with each other. For example, the respiratory effort may be determined based on a photo-plethysmographic waveform generated from light attenuation detected by the sensor, and the blood oxygen saturation may be a pulse -based estimate of arterial blood oxygen saturation determined from the detected attenuation. Analysis of the parameters may enable detection and classification of apnea (e.g., obstructive or central) or another underlying cause for respiratory instability. Furthermore, the measured respiratory effort may be compared to respiratory effort supplied by a ventilator to ensure proper sensor placement before enabling automatic adjustment of ventilator settings.

Abstract: Embodiments of the present disclosure relate to a system and method for determining a likelihood of successful ventilator weaning for a patient undergoing mechanical or assisted ventilation. Specifically, embodiments provided herein include methods and systems for determining or predicting weaning readiness in a patient based on physiological parameters determined via photoplethysmography.

Abstract: A monitoring system is disclosed for in vivo monitoring of preselected physiological parameters associated with acute and/or chronic tissue compromise or failure in one or multiple tissue/organ sites in real time. In one method, a body portion of a surgical stapling device is positioned adjacent a first tissue section, an anvil assembly adapted to engage the body portion is positioned adjacent a second tissue section, and a monitoring device is positioned adjacent the first and/or second tissue sections. The monitoring device includes a sensor adapted to measure a preselected physiological parameter and a transmitter for transmitting signal to an extracorporeal receiving unit. The surgical stapling device is fired to mechanically secure the first and second tissue sections with at least one staple and the preselected physiological parameter is monitored via the information transmitted from the monitoring device to the receiving unit.

Abstract: A sensor for physiological constituent detection may be adapted to include a mucoadhesive. A sensor is provided that is appropriate for use on mucosal tissue. The mucoadhesive provides a mechanism for holding the sensor on the mucous membrane in order to measure physiological constituent levels in the tissue and blood.

Abstract: According to various embodiments, a medical system and method for early detection of shock and/or sepsis may include devices configured to provide information about carbon dioxide and/or pH levels in a patient's tracheal tissue and in a respiratory path. Specifically, a relationship between carbon dioxide and/or pH in the tracheal tissue vs. respiratory gases (e.g., lung gases) may be used to determine if a patient is at risk of developing shock or sepsis. In certain embodiments, if carbon dioxide in the tracheal tissue deviates from end-tidal carbon dioxide, a patient may be experiencing early stages of hypoperfusion associated with shock and/or sepsis.

Abstract: Embodiments of the present disclosure relate to determining changes in a vasculature by analyzing changes in one or more attributes of a plethysmographic signal. According to certain embodiments, an apparatus may obtain plethysmographic signals prior to and subsequent to the administration of a vasoactive stimulus. The apparatus may include a processing unit configured to analyze and to compare attributes of the plethysmographic signals. The processing unit may correlate any changes in signal attributes to a change in a physiological condition of the vasculature (e.g., vascular tone/compliance). The apparatus may also include a display unit configured to present any changes in the vasculature as well as any alarms in response to a trigger from the processing unit.

Abstract: A sensor for physiological constituent detection may be adapted to include a mucoadhesive. A sensor is provided that is appropriate for use on mucosal tissue. The mucoadhesive provides a mechanism for holding the sensor on the mucous membrane in order to measure physiological constituent levels in the tissue and blood.

Abstract: Systems and methods are disclosed herein for maintaining the calibration of non-invasive blood pressure monitoring devices. Phase components of pulse signals detected by the blood pressure monitoring device are compared to stored baseline phase component values. If the difference exceeds a threshold, the blood pressure monitoring device is recalibrated.

Abstract: The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.

Abstract: A system for tissue ischemia detection is provided that may be used to assess markers of tissue ischemia. Such a system may include a sensor that may be used directly on internal tissue to assess ischemic condition. Sensors to be used in conjunction with the provided system may include optical, chemical or electrochemical sensors that may be directly applied or affixed to the tissue, held proximate to the tissue, or spread over the tissue in the form of a gel.