Abstract: According to various embodiments, a system, method, and sensor are provided that is capable of monitoring electrical impedance of oral or nasal mucosal tissue. Such sensors may be appropriate for assessing gut hypoperfusion, gut ischemia, or the onset of shock. The electrical impedance of the oral mucosa or other tissues in the upper respiratory tract may be used to non-invasively assess the clinical state of gastrointestinal tissue.

Abstract: A system and method are provided for determining tissue hydration. The method includes transmitting electromagnetic radiation at tissue and detecting the absorption spectrum of the tissue using a spectrum analyzer located in a sensor. Further, the method includes providing a signal correlative to the absorption spectrum from the spectrum analyzer to a monitor and processing the signal to determine an amount of water content in the tissue.

Abstract: The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the results of the spectroscopic measurements are used to control the administration of a drug through an intravenous tube. In other embodiments, the microneedles may be coated with a drug for administration to the patient. In other embodiments, the microneedles may be mounted in a probe, wherein an actuator is used to move the needles into contact with the skin, and a drug delivery system is used to infuse the drug into the patient. A method for making needles is also provided.

Abstract: A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.

Abstract: A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.

Abstract: Embodiments of the present invention relate to a system and method for monitoring intracranial pressure. Embodiments of the present invention include emitting an electromagnetic wavelength into forehead tissue of a patient and detecting characteristics of the electromagnetic wavelength after the electromagnetic wavelength has been scattered by the tissue. The characteristics may include variations in the electromagnetic wavelength corresponding to a pulse. Further, embodiments of the present invention include analyzing the variations to identify venous pulsations, and determining whether intracranial pressure is elevated in the patient based on a correlation between the venous pulsations and levels of intracranial pressure.

Abstract: An inflatable balloon cuff may be adapted to seal a patient's trachea via a mucoadhesive coating when associated with an endotracheal tube. The mucoadhesive seal may enhance a cuffs mechanical pressure seal, or may be used to seal the trachea at very low cuff inflation pressures. Also provided are inflatable balloon cuffs that include agents that may promote tracheal tissue growth and/or regeneration.