Patents by Inventor Shapiro

Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrode Assembly for Applying Tumor Treating Fields (TTFields) that Includes a Plurality of Thermally Linked but Electrically Isolated Graphite Sheets
    Publication number: 20240001111
    Abstract: Alternating electric fields (e.g., TTFields) may be applied to a subject's body using electrode assemblies, each of which includes a plurality of graphite sheets (or sheets of another conductive anisotropic material) that are positioned adjacent to, but not touching, each other. One or more electrode elements are disposed in electrical contact with each of the graphite sheets. Strips of electrically insulating and thermally conductive material are disposed between the graphite sheets, and these strips are positioned in thermal contact with the adjacent graphite sheets. The graphite sheets facilitate the passive spreading of heat within the confines of any given sheet. And the strips of material allow the passive spreading of heat to continue beyond the confines of any given sheet without compromising inter-sheet electrical isolation.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 4, 2024
    Applicant: Novocure GmbH
    Inventors: Yoram WASSERMAN, Stas OBUCHOVSKY, Nataliya KUPLENNIK, David SHAPIRO
  • Fabrication with image tracing
    Patent number: 11860606
    Abstract: A method may include generating, by a camera having a view of an interior portion of a computer-numerically-controlled machine, an image comprising a pattern. The image can be transformed into a set of machine instructions for controlling the computer-numerically-controlled machine to effect a change in a material. The change can correspond to at least a portion of the pattern. At least one machine instruction from the set of machine instructions can be executed to control the computer-numerically-controlled machine to effect at least a portion of the change. The execution can include operating, in accordance with the at least one machine instruction, a tool coupled with the computer-numerically-controlled machine. The tool can be configured to effect the change on the material. Related systems and articles of manufacture, including computer program products, are also provided.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: January 2, 2024
    Assignee: Glowforge, Inc.
    Inventors: Daniel Shapiro, Mark Gosselin, Anthony Wright, Jonathan Park, Kevin McVey, Scott Haug, Rachael Ludwick, Daniel Martinec
  • Door
    Patent number: 11859433
    Abstract: A door for allowing access to an interior space of a housing, one end of the housing is sealed with a cover having a plurality of cover components, the door comprising: a sun gear comprising a rotational axis, the sun gear is attached to the housing; a ring having a central axis coaxially disposed with the rotational axis of the sun gear; and a plurality of planetary gears evenly distributed about the central axis of the ring, each the planetary gear comprising a rotational axis and rotationally coupled to the ring and the sun gear, wherein the rotational axis of each the planetary gear is disposed parallel to the central axis of the ring, wherein each of the cover components is configured to be attached to one of the plurality of planetary gears and when the ring is rotated with respect to the housing, the plurality of cover components separate.
    Type: Grant
    Filed: December 11, 2021
    Date of Patent: January 2, 2024
    Inventor: Mikhail D. Shapiro
  • Calibration of a computer-numerically-controlled machine
    Patent number: 11860601
    Abstract: A method for calibrating a computer-numerically-controlled machine can include capturing one or more images of at least a portion of the computer-numerically-controlled machine. The one or more images can be captured with at least one camera located inside an enclosure containing a material bed. A mapping relationship can be created which maps a pixel in the one or more images to a location within the computer-numerically controlled machine. The creation of the mapping relationship can include compensating for a difference in the one or more images relative to one or more physical parameters of the computer-numerically-controlled machine and/or a material positioned on the material bed. Related systems and/or articles of manufacture, including computer program products, are also provided.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: January 2, 2024
    Assignee: Glowforge Inc.
    Inventors: Daniel Shapiro, Mark Gosselin, Anthony Wright, Kevin McVey, Jared Kofron, Daniel Martinec, Brian Fioca, Taylor Vaughn
  • GLP-1R modulating compounds
    Patent number: 11858918
    Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: January 2, 2024
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Megan K. Armstrong, James S. Cassidy, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Chao-I Hung, Kavoos Kolahdouzan, David W. Lin, Michael L. Mitchell, Ezra Roberts, Scott D. Schroeder, Nathan D. Shapiro, James G. Taylor, Rhiannon Thomas-Tran, Nathan E. Wright, Zheng-Yu Yang
  • Ocean thermal energy conversion power plant
    Patent number: 11859597
    Abstract: An offshore power generation structure comprising a submerged portion having a first deck portion comprising an integral multi-stage evaporator system, a second deck portion comprising an integral multi-stage condensing system, a third deck portion housing power generation equipment, cold water pipe; and a cold water pipe connection.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: January 2, 2024
    Assignee: The Abell Foundation, Inc.
    Inventors: Barry R. Cole, Jonathan M. Ross, Andrew Rekret, Henry Sibenaller, William Schulz, Russ Krull, Laurence Jay Shapiro
  • USE OF ANTI-AGING GLYCOPEPTIDES TO ENHANCE PANCREATIC CELL HEALTH, SURVIVAL AND IMPROVE TRANSPLANT OUTCOME
    Publication number: 20230414675
    Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
    Type: Application
    Filed: September 7, 2023
    Publication date: December 28, 2023
    Inventors: Lachlan Grant Young, A.M. James Shapiro
  • USE OF INSULIN-LIKE GROWTH FACTORS WITH GAMMA-CHAIN CYTOKINES TO INDUCE HOMEOSTATIC PROLIFERATION OF LYMPHOCYTES
    Publication number: 20230414720
    Abstract: Low-dose IL-2 has been proposed as a therapy to rectify regulatory T cell (Treg) fitness in type 1 diabetes (T1D). Identification of a combinatorial approach permits lower IL-2 dosing and avoids off-target effects. Insulin-like growth factor-1 (IGF1) is a hormone that promotes immunoregulation. Disclosed are methods that synergizes IGF1 with IL-2 to expand Tregs. In vivo IL-2+IGF1 treatment expands murine Tregs to a greater extent than either agent alone. IGF1+IL-2 treatment permits gene transfer in primary human Treg without the requirement for conventional activation stimuli, observing that IGF1+IL-2 maintains Treg naivety.
    Type: Application
    Filed: November 23, 2021
    Publication date: December 28, 2023
    Inventors: Todd Michael BRUSKO, Melanie SHAPIRO
  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20230414443
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Application
    Filed: September 6, 2023
    Publication date: December 28, 2023
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • MACHINE-LEARNING ERROR-CORRECTING CODE CONTROLLER
    Publication number: 20230421176
    Abstract: A machine-learning (ML) error-correcting code (ECC) controller may include a hard-decision (HD) ECC decoder optimized for high-speed data throughput, a soft-decision (SD) ECC decoder optimized for high-correctability data throughput, and a machine-learning equalizer (MLE) configured to variably select one of the HD ECC decoder or the SD ECC decoder for data throughput. An embodiment of the ML ECC controller may provide speed-optimized HD throughput based on a linear ECC. The linear ECC may be a soft Hamming permutation code (SHPC).
    Type: Application
    Filed: July 31, 2023
    Publication date: December 28, 2023
    Inventors: Ariel DOUBCHAK, Dikla SHAPIRO, Evgeny BLAICHMAN, Lital COHEN, Amit BERMAN
  • SYSTEM AND METHOD FOR SEGMENTING USERS OF A CLIENT APPLICATION
    Publication number: 20230418635
    Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.
    Type: Application
    Filed: September 12, 2023
    Publication date: December 28, 2023
    Inventors: Damien Simon Dykman, Andrew Reynolds Meckel, Samuel York Baker, Adam Dustin Shapiro, Shraddhaben A. Padariya, Raghav Ramakrishnan, Jonathan Lee, Dean Xu Chen, Philippe-Guillaume Victor David Losembe Botumbe, Amber Dai Milavec, Aharon Weisberg, Gabriel T. Schnaubelt, Kevin Babb, Siddharth Shankar, Zack Garbowitz
  • SYSTEMS AND METHODS FOR PROVIDING A DECENTRALIZED VOLATILITY PLATFORM FOR CRYPTOCURRENCY OPTION TRADING
    Publication number: 20230419406
    Abstract: A device may upon an option activation via a smart contract, initializing a set of parameters, wherein the smart contract operates on a blockchain network. A device may compute via the smart contract an expected price range for an underlier based on the set of parameters. A device may subdivide via the smart contract the expected price range into a fixed number of standard risk blocks, wherein each respective standard risk block of the fixed number of standard risk blocks includes a price interval centered around a specific value, wherein each standard risk block includes a binary state dependent unit that pays at an expiration of an option lifecycle a fixed amount for a purchased stake if a reference value meets a specific condition, and nothing otherwise. A device may handle via the smart contract a settlement of options via payment of stakes purchased in standard risk blocks.
    Type: Application
    Filed: May 18, 2023
    Publication date: December 28, 2023
    Inventors: Lev Gelfer, Sergei Levin, Greg Gurevich, Sergey Shevchuk, Boris Shapiro
  • CARM1 INHIBITORS AND USES THEREOF
    Publication number: 20230416263
    Abstract: Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
    Type: Application
    Filed: November 23, 2022
    Publication date: December 28, 2023
    Applicant: Epizyme, Inc.
    Inventors: Richard Chesworth, Oscar Miguel Moradei, Gideon Shapiro, Lei Jin, Robert E. Babine
  • Apparatus Comprising Dielectric Layer Coupled To Anisotropic Layer
    Publication number: 20230414931
    Abstract: An apparatus includes an outer adhesive layer comprising a conductive gel or conductive adhesive, at least one layer of anisotropic material, a layer of dielectric material, and a skin contact layer comprising a conductive gel or conductive adhesive. The at least one layer of anisotropic material and the layer of dielectric material are positioned between the outer adhesive layer and the skin contact layer. The layer of dielectric material contacts at least a first layer of the at least one layer of anisotropic material to form a capacitive structure.
    Type: Application
    Filed: June 28, 2023
    Publication date: December 28, 2023
    Inventors: David Shapiro, Yoram Wasserman, Stas Obuchovsky
  • CATALYTIC SEQUENCE BASED METHODS OF TREATING OR PREVENTING BACTERIAL INFECTIONS
    Publication number: 20230416750
    Abstract: An oligonucleotide is provided. The oligonucleotide comprising a nucleic acid sequence of at least one DNAzyme, the DNAzyme being capable of silencing at least one target gene of a bacteria to thereby render the bacteria susceptible to antibiotic treatment.
    Type: Application
    Filed: November 9, 2021
    Publication date: December 28, 2023
    Applicant: 1E Therapeutics Ltd.
    Inventors: Ido Bachelet, Almogit Horowitz, Alexander Rosenberg, Anastasia Shapiro, Ron Oshri, Ilana Kolodkin-Gal, Adva Levy-Zamir, Gat Krieger, Ella GILLIS, Shmulik ITTAH
  • Methods and devices to improve switching time by bypassing gate resistor
    Patent number: 11855611
    Abstract: Implementing a series gate resistor in a switching circuit results in several performance improvements. Few examples are better insertion loss, lower breakdown voltage requirements and a lower frequency corner. These benefits come at the expense of a slower switching time. Methods and devices offering solutions to this problem are described. Using a concept of bypassing the series gate resistor during transition time, a fast switching time can be achieved while the above-mentioned performance improvements are maintained.
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: December 26, 2023
    Assignee: pSemi Corporation
    Inventors: Payman Shanjani, Eric S. Shapiro
  • Pass-through command queues for unmodified storage drivers
    Patent number: 11853610
    Abstract: A storage device for providing data storage services to a host includes persistent storage for storing a file and a controller. The controller obtains a write request from the host for the file, the write request comprises a command packet; perform processing of the command packet using a payload portion of the file; generate a response packet based on the processing of the command packet; and store the response packet in a response portion of the file in response to the write request.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: December 26, 2023
    Assignee: iodyne, LLC
    Inventor: Michael W. Shapiro
  • Machine learning extraction of clinical variable values for subjects from clinical record data
    Patent number: 11854675
    Abstract: Described herein are techniques of using machine learning to automatically extract clinical variable values for subjects from clinical record data. The techniques designate certain clinical variables as hybrid variables that can be assigned values by machine learning model prediction. The techniques process, using a machine learning model trained to predict a value of a hybrid variable, clinical record data associated with a subject to obtain a predicted hybrid variable value and an associated confidence score. The techniques set the value of the hybrid variable for the subject to the predicted hybrid variable value when the model prediction is of sufficiently high confidence.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: December 26, 2023
    Assignee: Flatiron Health, Inc.
    Inventors: Brett Wittmershaus, Guy Amster, Michael Waskom, Natalie Roher, Nisha Singh, Sharang Phadke, Will Shapiro
  • MULTIPLEX INERTIAL FILTER, COLLECTOR AND SEPARATOR
    Publication number: 20230405501
    Abstract: Methods and systems are provided for a multiplexed phase separating inertial filter that is composed of helical through holes generating centrifugal separating forces. In one example, the inertial filter may be a planar porous material with an array of helical channels, each helical channel of the array of helical channels extending from a top surface of the porous material to a bottom surface of the porous material.
    Type: Application
    Filed: August 25, 2023
    Publication date: December 21, 2023
    Inventors: Mark M. Weislogel, John C. Graf, Nora D. Shapiro, Logan Torres, Rawand M. Rasheed, Ryan Jenson
  • ROTATABLE RETROFIT TRIM LIGHTING DEVICE
    Publication number: 20230408073
    Abstract: A retrofit trim lighting device is provided. In example embodiments, the retrofit trim lighting device comprises a bracket comprising an opening; at least one torsion spring secured to the bracket and configured to mount the retrofit trim lighting device within a recessed housing; a retrofit housing comprising at least one light engine; and an engagement element. The engagement element is secured to the retrofit housing through the opening of the bracket such that, when so secured, the retrofit housing and the bracket are rotatable relative to one another.
    Type: Application
    Filed: September 5, 2023
    Publication date: December 21, 2023
    Inventor: Jim Shapiro