Abstract: Disclosed herein are oral compositions comprising an amino acid and a gelling agent. In certain embodiments, the chewable composition is in the form of a gummy comprising arginine and pectin. Related kits and methods of use are further provided.

Abstract: Disclosed herein are improved methods for the manufacture of arginine-based dentifrice compositions comprising the use of a solution of arginine free base (e.g., L-arginine) in concentrated aqueous sorbitol solution.

Abstract: Described herein are oral care compositions comprising—in relevant part—an effective amount of inulin. Methods of making and using these compositions are also described.

Abstract: This invention relates to solid oral care compositions, for example a tablet, comprising a binder system. In certain aspects the invention is directed to solid oral care compositions that are tablets that comprise a binder system, wherein the binder system comprises polyvinyl pyrrolidone and hydroxyethyl cellulose, and to methods of using and of making these compositions.

Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor, in an orally acceptable gel base, the gel base comprising an anionic polymer and a basic amino acid, and the analgesic gel providing controlled release of the mixture of analgesic oils following application to a tooth together with a methods of making and using the same.

Abstract: Provided is an oral care composition, e.g., a dentifrice, comprising a calcium abrasive, e.g., calcium carbonate, potassium nitrate (KNO3), and a basic amino acid, in free or salt form, e.g., arginine, in free or salt form, wherein the potassium nitrate is present in an amount of 0.1-1% by weight of the composition and methods of using the same.

Abstract: Provided is an oral care composition, e.g., a dentifrice, comprising a calcium abrasive, e.g., calcium carbonate, potassium nitrate (KNO3), and a basic amino acid, in free or salt form, e.g., arginine, in free or salt form, wherein the potassium nitrate is present in an amount of 0.1-1% by weight of the composition and methods of using the same.

Abstract: Use of benzyl alcohol as a defoaming agent and an antimicrobial agent in an oral care composition including a surfactant. Also described is a method of manufacturing an oral care composition including forming an oral care base composition, subsequently combining the oral care base composition with a defoaming agent and at least one surfactant to form the oral care composition; and defoaming the oral care composition. The surfactant is combined with the oral care base composition no later than the defoaming agent. The defoaming agent is benzyl alcohol.

Abstract: Surface staining can be minimized or eliminated by providing an oral care composition comprising a first film comprising a pigment; and optionally a second film; wherein the first film has a dissolution rate in aqueous media that is inversely proportional to its thickness, wherein the first film is in the form of a particle.

Abstract: Described herein are high yield methods for making magnolol derivatives, together with novel intermediates and uses thereof.

Abstract: The invention provides antibacterial combinations of essential oils comprising bisabolol and one or more essential oils selected from citral, carvacrol, oregano extract, and rosemary, or comprising carvacrol and one or more essential oils selected from bisabolol, thymol, and rosemary, together with compositions, e.g., oral care compositions, comprising these combinations, and uses therefore.

Abstract: Procedures are provided to evaluate the effectiveness of slow-acting antibacterial agents such as metal salts on reduction of bacterial oral biofilm. In the modified process, the exposure time of the agent is increased from the usual 3 minutes to 7-15 minutes, e.g., about 10 minutes, and the duration increased to 5-12 days, e.g., about 8 days instead of the conventional 3 days.

Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.

Abstract: The present application provides a tooth anatomy model comprising: a first layer representing tooth dentin, said first layer being made of a first material; and a sensor system associated with a surface of the first layer, which system is adapted to sense at least one of temperature and air pressure. The present application also provides a method of demonstrating tooth hypersensitivity using a tooth anatomy model.

Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor, in an orally acceptable gel base, the gel base comprising an anionic polymer and a basic amino acid, and the analgesic gel providing controlled release of the mixture of analgesic oils following application to a tooth together with a methods of making and using the same.

Abstract: Use of benzyl alcohol as a defoaming agent and an antimicrobial agent in an oral care composition including a surfactant. Also described is a method of manufacturing an oral care composition including forming an oral care base composition, subsequently combining the oral care base composition with a defoaming agent and at least one surfactant to form the oral care composition; and defoaming the oral care composition. The surfactant is combined with the oral care base composition no later than the defoaming agent. The defoaming agent is benzyl alcohol.

Abstract: The invention provides antibacterial combinations of essential oils comprising bisabolol and one or more essential oils selected from citral, carvacrol, oregano extract, and rosemary, or comprising carvacrol and one or more essential oils selected from bisabolol, thymol, and rosemary, together with compositions, e.g., oral care compositions, comprising these combinations, and uses therefore.

Abstract: Procedures are provided to evaluate the effectiveness of slow-acting antibacterial agents such as metal salts on reduction of bacterial oral biofilm. In the modified process, the exposure time of the agent is increased from the usual 3 minutes to 7-15 minutes, e.g., about 10 minutes, and the duration increased to 5-12 days, e.g., about 8 days instead of the conventional 3 days.

Abstract: Described herein are toothpastes comprising a first dentifrice comprising a calcium carbonate abrasive and a second dentifrice comprising a zinc ion source in a gel base, wherein the second dentifrice is entrained as a stripe in the first dentifrice, as well as products comprising the toothpaste and methods of making and using the same.

Abstract: Described herein are high yield methods for making magnolol derivatives, together with novel intermediates and uses thereof.