Patents by Inventor Shawn DeFrees

Shawn DeFrees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycopeptide remodeling using amidases
    Publication number: 20050118672
    Abstract: This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a homogeneous glycosylation pattern.
    Type: Application
    Filed: November 27, 2002
    Publication date: June 2, 2005
    Inventors: Shawn DeFrees, Karl Johnson
  • Remodeling and glycoconjugation of peptides
    Publication number: 20050106658
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group of peptide.
    Type: Application
    Filed: October 9, 2002
    Publication date: May 19, 2005
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Factor IX: remodeling and glycoconjugation of factor IX
    Publication number: 20050100982
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: May 12, 2005
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycoprotein remodeling using endoglycanases
    Publication number: 20050064540
    Abstract: This invention provides methods for modifying glycosylation patterns of glycoproteins, including recombinantly produced glycoproteins. Also provided are glycoprotein compositions in which the glycoproteins have a homogeneous glycosylation pattern.
    Type: Application
    Filed: November 27, 2002
    Publication date: March 24, 2005
    Inventors: Shawn Defrees, Karl Johnson
  • Chemo-enzymatic synthesis of sialylated oligosaccharides
    Publication number: 20050032742
    Abstract: In vitro/cell-free process of preparing a sialylated oligosaccharides are described. The sialylated oligosaccharides include gangliosides. The oligosaccharides linked to various moieties including sphingoids and ceramides. Novel compounds that comprise sphingoid groups are disclosed. The compounds include sialylated oligosaccharides including gangliosides as well as various sphingoids and ceramides.
    Type: Application
    Filed: August 1, 2002
    Publication date: February 10, 2005
    Inventors: Shawn DeFrees, Edward McGuire
  • Interleukin-2:remodeling and glycoconjugation of interleukin-2
    Publication number: 20050031584
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: February 10, 2005
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycoconjugation methods and proteins/peptides produced by the methods
    Publication number: 20040142856
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: July 22, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Remodeling and glycoconjugation of peptides
    Publication number: 20040137557
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Application
    Filed: November 5, 2002
    Publication date: July 15, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylation methods and proteins/peptides produced by the methods
    Publication number: 20040132640
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: July 8, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Follicle stimulating hormone: remodeling and glycoconjugation of FSH
    Publication number: 20040126838
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: July 1, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Interferon beta: remodeling and glycoconjugation of interferon beta
    Publication number: 20040115168
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: June 17, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Interferon alpha: remodeling and glycoconjugation of interferon alpha
    Publication number: 20040082026
    Abstract: The invention includes a multitude of methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: April 29, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Publication number: 20040077836
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: April 22, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Protein remodeling methods and proteins/peptides produced by the methods
    Publication number: 20040063911
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: April 1, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Xi Chen
  • Glycosyltransferase inhibitors
    Publication number: 20040048325
    Abstract: This invention provides potent inhibitors of glycosyltransferases. The glyscosyltransferase inhibitors are useful for inhibiting the synthesis of glycosides. Accordingly, the glycosyltransferase inhibitors find use, for example, in the modulation of biological processes that involve glycoside-mediated cell adhesion.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 11, 2004
    Applicant: Abaron Biosciences, Inc.
    Inventor: Shawn DeFrees
  • Alpha galalctosidase a: remodeling and glycoconjugation of alpha galactosidase A
    Publication number: 20040043446
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: March 4, 2004
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
    Publication number: 20030029799
    Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
    Type: Application
    Filed: June 27, 2002
    Publication date: February 13, 2003
    Applicant: Neose Technologies
    Inventor: Shawn DeFrees
  • Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
    Publication number: 20020148791
    Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
    Type: Application
    Filed: March 22, 2002
    Publication date: October 17, 2002
    Applicant: Neose Technologies
    Inventor: Shawn DeFrees
  • Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
    Patent number: 6454946
    Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: September 24, 2002
    Assignee: Neose Technologies, Inc.
    Inventor: Shawn DeFrees
  • Enzymatic synthesis of gangliosides
    Patent number: 6440703
    Abstract: This invention provides methods for practical in vitro synthesis of gangliosides and other glycolipids. The synthetic methods typically involve enzymatic synthesis, or a combination of enzymatic and chemical synthesis. One or more of the enzymatic steps is preferably carried out in the presence of an organic solvent.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: August 27, 2002
    Assignee: Neose Technologies, Inc.
    Inventor: Shawn DeFrees