Patents by Inventor Shawn DeFrees

Shawn DeFrees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Patent number: 7173003
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: February 6, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylation methods and proteins/peptides produced by the methods
    Publication number: 20070026485
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2004
    Publication date: February 1, 2007
    Applicant: NEOSE TECHNOLOGIES, INC.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20070027068
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: October 8, 2003
    Publication date: February 1, 2007
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Glycopegylated granulocyte colony stimulating factor
    Publication number: 20070014759
    Abstract: The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: November 2, 2005
    Publication date: January 18, 2007
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Henrik Clausen, David Zopf, Zhi-Guang Wang, Caryn Bowe
  • Factor VIII remodeling and glycoconjugation of Factor VIII
    Patent number: 7157277
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: January 2, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylated erythropoietin formulations
    Publication number: 20060287224
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: May 25, 2006
    Publication date: December 21, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert Bayer, David Zopf, Jichao Kang, Walter Willett
  • Remodeling and glycoconjugation of peptides
    Publication number: 20060287223
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Application
    Filed: April 12, 2006
    Publication date: December 21, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Caryn Bowe
  • Activated forms of water-soluble polymers
    Publication number: 20060276618
    Abstract: The present invention provides compositions of activated water-soluble polymers for preparing water-soluble polymer-modified peptides. Exemplary compounds of the invention include water-soluble polymers covalently attached to activated leaving groups wherein the water-soluble polymer is a member selected from PEG, PPG, PEG derivatives, and PPG derivatives, and the activated leaving group is a member selected from (formula I).
    Type: Application
    Filed: March 18, 2004
    Publication date: December 7, 2006
    Inventors: Shawn DeFrees, David Zopf, Caryn Bowe
  • Remodeling and glycoconjugation of peptides
    Patent number: 7138371
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: November 21, 2006
    Assignee: Neose Technologies, Inc
    Inventors: Shawn DeFrees, David A. Zopf, Caryn Bowe
  • Glycoconjugates including more than one peptide
    Patent number: 7125843
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 24, 2006
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylated erythropoietin
    Publication number: 20060111279
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: June 2, 2005
    Publication date: May 25, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert Bayer, David Zopf
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20060088906
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: July 15, 2005
    Publication date: April 27, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycopegylated factor IX
    Publication number: 20060040856
    Abstract: The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: June 23, 2005
    Publication date: February 23, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert Bayer, Caryn Bowe, Krishnasamy Panneerselvam
  • Remodeling and glycoconjugation of peptides
    Publication number: 20060030521
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 9, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
    Publication number: 20050269265
    Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 8, 2005
    Applicant: Neose Technologies
    Inventor: Shawn DeFrees
  • O-linked glycosylation of peptides
    Publication number: 20050250678
    Abstract: The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.
    Type: Application
    Filed: January 10, 2005
    Publication date: November 10, 2005
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Zhi-Guang Wang, Henrik Clausen
  • Neutral glycosphingolipids and glycosyl-sphingosines and methods for isolating the same
    Publication number: 20050245735
    Abstract: In vitro/cell-free process of preparing a sialylated oligosaccharides are described. The sialylated oligosaccharides include gangliosides. The oligosaccharides linked to various moieties including sphingoids and ceramides. Novel compounds that comprise sphingoid groups are disclosed. The compounds include sialylated oligosaccharides including gangliosides as well as various sphingoids and ceramides.
    Type: Application
    Filed: August 1, 2002
    Publication date: November 3, 2005
    Inventor: Shawn DeFrees
  • Novel synthetic ganglioside derivatives and compositions thereof
    Publication number: 20050239741
    Abstract: Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.
    Type: Application
    Filed: August 29, 2002
    Publication date: October 27, 2005
    Inventors: Shawn Defrees, Zhi Wang
  • Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
    Patent number: 6936173
    Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 30, 2005
    Assignee: Neose Technologies, Inc.
    Inventor: Shawn DeFrees
  • Glycopegylated erythropoietin
    Publication number: 20050143292
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: November 24, 2004
    Publication date: June 30, 2005
    Inventors: Shawn DeFrees, Robert Bayer, David Zopf