Patents by Inventor Shawn O'Connor

Shawn O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    Publication number: 20110262937
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: May 2, 2011
    Publication date: October 27, 2011
    Applicant: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Heteromeric taste receptors comprising T1R2/T1R3 domains
    Patent number: 8039590
    Abstract: Heteromeric taste receptors are provided. These receptors comprise a first polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R2 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R2 polypeptide or a different GPCR; and a second polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R3 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R3 polypeptide or that of a different GPCR.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: October 18, 2011
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • ASSAYS THAT USE THE T1R1 RECEPTOR POLYPEPTIDES TO SCREEN FOR T1R1-ASSOCIATED TASTE MODULATORS
    Publication number: 20110244563
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: April 15, 2011
    Publication date: October 6, 2011
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
  • METHOD OF PREPARING A FLEXIBLE SUBSTRATE ASSEMBLY AND FLEXIBLE SUBSTRATE ASSEMBLY THEREFROM
    Publication number: 20110228492
    Abstract: Some embodiments teach a method of preparing a flexible substrate assembly. The method can include: (a) providing a carrier substrate; (b) providing a cross-linking adhesive; (c) providing a plastic substrate; and (d) coupling the carrier substrate to the plastic substrate using the cross-linking adhesive. Other embodiments are disclosed in this application.
    Type: Application
    Filed: May 27, 2011
    Publication date: September 22, 2011
    Applicant: Arizona Board of Regents, for and on behalf of Arizona State University
    Inventors: Jesmin Haq, Scott Ageno, Douglas E. Loy, Shawn O'Rourke, Robert Naujokaitis
  • BINDING AND FUNCTIONAL ASSAYS THAT USE THE T1R3 RECEPTOR TO SCREEN FOR TASTE MODULATORY COMPOUNDS
    Publication number: 20110207133
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: April 22, 2011
    Publication date: August 25, 2011
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiaodong Li, Shawn O'Connell, Lena Staszewski
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    Publication number: 20110207148
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: February 28, 2011
    Publication date: August 25, 2011
    Applicant: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • T1R TASTE RECEPTORS AND GENES ENCODING SAME
    Publication number: 20110207212
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: February 9, 2011
    Publication date: August 25, 2011
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiaodong Li, Shawn O'Connell, Lena Staszewski
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    Publication number: 20110201020
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 18, 2011
    Applicant: SENOMYX, INC.
    Inventors: MARK ZOLLER, XIAODONG LI, LENA STASZEWSKI, SHAWN O'CONNELL, SERGEY ZOZULYA, JON ELLIOT ADLER, HONG XU, FERNANDO ECHEVERRI
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    Publication number: 20110201028
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 18, 2011
    Applicant: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Ancillary tool for fitting a humeral component of an elbow prosthesis
    Patent number: 7942882
    Abstract: An ancillary tool for fitting a humeral component of a total or partial elbow prosthesis, comprising a guiding tool (30) for boring a humeral trochlea (T) along a geometric axis (X-X?) of bend of a joint to be equipped with said prosthesis. The guiding tool (30) includes a stirrup element (31) and means (32b, 33b) for securing said stirrup element on the humeral trochlea (T) so that said guiding tool defines a guiding zone that is aligned in the geometric axis of bend for the introduction (F1) of a drill (40), a punch or the like, in the humeral trochlea (T) along said geometric axis of bend. This ancillary tool also comprises at least one stepped template (701, 702, 703) for determining an anterior offset of said geometric axis of bend (X-X?) with respect to a humeral diaphyseal axis (Y-Y?).
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: May 17, 2011
    Assignee: Tornier SAS
    Inventors: Alain Tornier, Shawn O'Driscoll, Graham King, Ken Yamaguchi, Yves Alain Ratron, Bruno Scialom
  • Assays using chimeric T1R3 taste receptor polypeptides
    Patent number: 7927823
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: April 19, 2011
    Assignee: Senomyx, Inc.
    Inventors: Jon Elliott Adler, Sergey Zozulya, Xiaodong Li, Shawn O'Connell, Lena Staszewski
  • Methods of using T1R2/T1R3 heteromeric receptors to quantify taste of compounds for food or beverages
    Patent number: 7927825
    Abstract: Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one T1R2 polypeptide and at least one T1R3 polypeptide.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: April 19, 2011
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Ancillary tool for fitting an ulnar component and/or a radial component of an elbow prosthesis
    Patent number: 7922728
    Abstract: An ancillary tool (10) comprising a trial humeral trochlea (202) that is representative of an anatomical humeral trochlea when the trial humeral trochlea is in place with respect to corresponding cubital (SC) and/or radial (SR) articular surfaces and a cut-out guide (30) for cutting an ulna (C) and/or a radius (R), wherein the cut-out guide (30) is adapted to be positioned with respect to the trial humeral trochlea (202). The cut-out guide (30) is also adapted to be positioned with respect to an ulna (C) and/or to a radius (R) equipped with the trial humeral trochlea (202).
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: April 12, 2011
    Assignee: Tornier SAS
    Inventors: Alain Tornier, Shawn O'Driscoll, Graham King, Ken Yamaguchi, Yves Alain Ratron, Bruno Scialom
  • T1R3 BINDING ASSAYS
    Publication number: 20110081658
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: September 2, 2010
    Publication date: April 7, 2011
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiaodong Li, Shawn O'Connell, Lena Staszewski
  • Methods for identifying compounds that modulate T1R1/T1R3 umami taste receptors
    Patent number: 7910322
    Abstract: Methods for identifying compounds that modulate the T1R1/T1R3 umami taste receptors are provided. These methods comprise screening one or more compounds in a binding assay which identifies compounds that specifically bind to a T1R1/T1R3 taste receptor or which specifically modulate the specific binding of another compound to a T1R1/T1R3 taste receptor, and identifying compounds that elicit or modulate T1R1/T1R3 taste.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: March 22, 2011
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Assemblies and Methods for Reducing Warp and Bow of a Flexible Substrate During Semiconductor Processing
    Publication number: 20110064953
    Abstract: Methods are described for addressing the bowing and/or warping of flexible substrates, attached to a rigid carrier, which occurs as a result of the thermal challenges of semiconductor processing. In particular, viscoelastic adhesives are provided which can bond a flexible substrate to a rigid carrier and mediate the thermal mismatch which often is present due to the distinctly different materials properties of most flexible substrates, such as plastic films, with respect to rigid carriers, such as silicon wafers. Assemblies are also provided which are produced according to the methods described herein.
    Type: Application
    Filed: April 6, 2009
    Publication date: March 17, 2011
    Applicant: Arizona Board of Regents, a body Corporate of the State of Arizona acting for and on the behalf of A
    Inventors: Shawn O'Rourke, Douglas Loy, Hanqing Jiang
  • Cell lines that express hetero oligomeric taste receptors
    Patent number: 7906328
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: March 15, 2011
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • DATA STORAGE DRIVE OVERWRITE PROTECTION OF NON-WORM CARTRIDGES
    Publication number: 20110051278
    Abstract: Protection against data overwrite of a rewritable non-WORM data storage cartridge is provided by a data storage drive operating cartridge data overwrite protection procedures independent of, or not withstanding, the absence of cartridge controls relating to data overwrite protection. Also for the non-WORM cartridge, the drive responds to an allow data overwrite command to allow an immediately subsequent write type command to write to the cartridge even if the write command overwrites existing data. The overwrite protection procedures and data overwrite procedures may be configured and enabled for the data storage drive.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 3, 2011
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: SHAWN O. BRUME, KEVIN D. BUTT, HIROKAZU NAKAYAMA
  • EXTENDED DATA STORAGE SYSTEM
    Publication number: 20110055272
    Abstract: In one embodiment, an extended data storage system employs a first data storage and an extended data storage. A first level of metadata is established with respect to data from the using entity, the first level of metadata is provided in the first data storage. The data from the using entity is stored in the extended data storage. A second level of metadata at least describing the data as stored in the extended data storage is also established, wherein the second level of metadata associated with the first level of metadata for the stored data. The first level of metadata is made accessible to the using entity at the first data storage; and the second level of metadata is made unavailable to the using entity. Thus, the data is stored in the extended data storage and a small amount of metadata is stored in the first data storage.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 3, 2011
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: SAID A. AHMAD, SHAWN O. BRUME
  • Elbow prosthesis
    Patent number: RE42805
    Abstract: A humeral component, forming a first articulating surface, and an ulnar component forming a second articulating surface adapted to be disposed around a part of the first articulating surface and to pivot about its longitudinal axis. This ulnar component is provided with structure for mounting a locking element which forms a third articulating surface extending the second and adapted likewise to be disposed around a part of the first surface. These mounting structure comprise guiding structures adapted to cooperate with complementary structure provided on the locking element in order to guide this element in translation with respect to the ulnar component, up to a position where blocking structure provided respectively on the locking element and on the ulnar component may be employed to immobilize this element on this component, these blocking structure being able to be employed only in this position.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: October 4, 2011
    Assignee: Tornier
    Inventors: Alain Tornier, Shawn O'Driscoll, Graham King, Ken Yamaguchi, Yves Alain Ratron, Bruno Scialom