Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: This description describes wagering game systems that include docking stations. In one embodiment, the apparatus includes a presentation unit configured to present a wagering game and a docking controller configured to detect when the apparatus is docked with a docking station and to detect when the apparatus is undocked from the docking station. The apparatus can also include a docking port, the docking port including at least one of a dock power unit configured to receive power via the docking station and a dock communication unit configured to receive wagering game content associated with the wagering game, the dock communication unit configured to receive the wagering game content when the apparatus is docked with the docking station. The apparatus can also include a wireless communication unit configured to receive the wagering game content when the docking controller when the apparatus is undocked from the docking station.

Abstract: Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically binds to a human T1R2 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enzymes, fluorophases, and the like. Compounds identified in these binding assays have putative application as T1R2 taste modulators, particularly sweet taste, and potentially are useful additives in compositions for human or animal consumption.

Abstract: A flexible, transparent electrode structure and a method of fabrication thereof are provided comprising a transparent electrode which may maintain electrical connectivity across a surface of a flexible substrate so that the substrate may flex without affecting the integrity of an electrical contact. The transparent electrode includes conductive nanowires that are coupled to the substrate through a conducting oxide layer. The conducting oxide layer effectively provides a template onto which the nanowires are deposited and serves to anchor the nanowires to the substrate surface.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.

Abstract: One embodiment according to the present invention includes an occlusion device in which the support structure or frame expands circumferentially within the lumen to secure an expansile plug or embolic material. Once in place, the expansile plug or embolic material expands, thereby occluding the target lumen. Another embodiment according to the present invention includes a radially expandable support structure having a closed portion for capturing subsequently delivered embolic material, such as embolic coils. For example, the structure may have a closed portion at its distal end or at its middle (forming an hourglass shape). Additionally, the closed portion may be formed from the support structure itself or from a discrete, second layer that is attached within the support structure.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: The invention concerns a method of making a thin film and/or particle having a grey scale code embedded in its physical structure by refractive index changes between different regions of the thin film or particle, as well as thin films and particles made by the method. In a preferred method for encoding a thin film, a semiconductor or insulator substrate is etched to form a thin film including pores. The etching conditions are controlled to vary porosity in the thin film according to a pattern that will generate an optical signature in the reflectivity spectrum in response to illumination such that the optical signature will including a grey scale code. The etching waveform is formed by the addition of at least two separate sine components in accordance with the following equations (1)An=(Anmax?Anmin)/2; (2) kn=frequency=1/period; (3) yn=An[sin(knt??)+1]+Anmin (4) ycomp=[y1+ . . .

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: According to one embodiment, a method for storing data on a magnetic tape comprises receiving data from two different hosts and simultaneously writing the data from the hosts to the magnetic tape using multiple transducers. In another approach, a method for storing data on a magnetic tape comprises receiving requests to establish a concurrent reservation from multiple hosts and allocating a unique stripe in a wrap to each of the hosts that sent the requests, wherein the wrap is a collection of data tracks to be written simultaneously in one direction of tape movement by multiple transducers of a tape head, and the wrap is logically divided into the stripes. Also, the method includes receiving data from the hosts and simultaneously writing the data from the hosts to the magnetic tape using the multiple transducers. Other systems and methods concerning storing data on magnetic tapes are described as well.

Abstract: In one embodiment, an extended data storage system employs a first data storage and an extended data storage. A first level of metadata is established with respect to data from the using entity, the first level of metadata is provided in the first data storage. The data from the using entity is stored in the extended data storage. A second level of metadata at least describing the data as stored in the extended data storage is also established, wherein the second level of metadata associated with the first level of metadata for the stored data. The first level of metadata is made accessible to the using entity at the first data storage; and the second level of metadata is made unavailable to the using entity. Thus, the data is stored in the extended data storage and a small amount of metadata is stored in the first data storage.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: According to one embodiment, a method for storing data on a magnetic tape comprises receiving data from two different hosts and simultaneously writing the data from the hosts to the magnetic tape using multiple transducers. In another approach, a method for storing data on a magnetic tape comprises receiving requests to establish a concurrent reservation from multiple hosts and allocating a unique stripe in a wrap to each of the hosts that sent the requests, wherein the wrap is a collection of data tracks to be written simultaneously in one direction of tape movement by multiple transducers of a tape head, and the wrap is logically divided into the stripes. Also, the method includes receiving data from the hosts and simultaneously writing the data from the hosts to the magnetic tape using the multiple transducers. Other systems and methods concerning storing data on magnetic tapes are described as well.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

Abstract: Embodiments of a handheld wagering game machine and docking station are described herein. In one embodiment, the wagering game docking station is configured to dock with a handheld wagering game machine. The docking station can include a docking port configured to receive and adjustably hold the handheld wagering game machine at any of a plurality of viewing angles. The docking station can also include a plurality of buttons configured to send input to the handheld wagering game machine. The docking station can also include a mounting member configured to mount the docking station to a surface.