Abstract: A system for treating tissue includes an applicator including a catheter and a control member extending therethrough, the control member longitudinally movable relative to the catheter and including an abutment structure proximate a distal end thereof, and a clip assembly releasably coupleable to a distal end of the applicator, the clip assembly including a pair of clip arms, a proximal end of each of the clip arms slidably received within a channel of a capsule and configured to be releasably coupled to the distal end of the control member so that the clip arms are movable relative to the capsule between a tissue receiving configuration and a tissue clipping configuration, the capsule including proximal tabs movable between a biased non-engaging and an engaging configuration, in which the proximal tabs engage an engaging portion of the lumen of the catheter, when the abutment structure is received within the capsule.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip jaws, proximal ends of which are slidably received within the channel of the capsule so that the clip jaws are movable between an open configuration and a closed configuration. Clip jaws are configured so that a distance between the distal ends of the clip jaws in an open configuration is between 15 and 18 millimeters. Clip jaws further include barbs extending from a distal portion thereof.

Abstract: A medical system including a porous body connected to a distal end of a vacuum tube, and a patch defining a lumen therethrough for accommodating the vacuum tube, where the patch is fluidly seals the porous body from a body lumen when the patch is deployed in a subject.

Abstract: A system for treating tissue includes a capsule including a channel extending therethrough; first and second clip arms each extending from a proximal end to a distal end, the proximal ends being received within the channel of a capsule to be moved between an open tissue receiving configuration; and a closed tissue clipping configuration. The first clip arm includes a first tissue retention feature at a distal portion thereof configured to pierce through a target tissue when in the tissue clipping configuration and subsequently release the target tissue when the clip arms are moved to an at least partially open configuration. The second clip arm includes a second tissue retention feature at a distal portion thereof configured to pierce and retain the target tissue thereon when in both the closed tissue clipping configuration and the open tissue receiving configuration.

Abstract: A system for treating tissue includes a clip assembly including a pair of clip arms, proximal ends of which are slidably received within a channel of a capsule to be moved between a tissue receiving configuration, in which distal ends of the clip arms are separated from one another, and a tissue clipping configuration, in which the distal ends are moved toward one another. The system also includes an applicator including a catheter and a control member extending therethrough. The control member configured to be connected to the clip arms to move the clip assembly between the tissue receiving and tissue clipping configurations. The system also includes a coupler attached to one of a proximal end of the capsule of the clip assembly and a distal end of the catheter, and configured to releasably couple the capsule and the catheter to one another.

Abstract: The present disclosure relates to the field of endoscopy. In particular, the present disclosure relates to systems and methods suitable for resecting or dissecting large areas of mucosal or submucosal tissue. The system may apply tension to and continuously manipulate mucosal tissue such that large lesions may be resected or dissected by a cutting element disposed at the distal end of an endoscope.

Abstract: Embodiments provide a computer-executable method, computer system and non-transitory computer-readable medium for programmatically processing text information to generate attribute descriptors contained therein. The method includes programmatically accessing, via a network device, a textual unit, the textual unit associated with a commercial entity or a commercial object. The method also includes executing a text processing engine to programmatically generate an attribute descriptor from the textual unit. The method further includes storing, on a non-transitory computer-readable storage device, the attribute descriptor in association with identification of the commercial entity or the commercial object.

Abstract: A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

Abstract: A device for treating a tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, clip arms, proximal ends of which are slidably received within the channel of the capsule so that the clip arms are movable between an open configuration, in which distal ends of the clip arms extend distally past the distal end of the capsule to be separated from one another, and a closed configuration, in which the clip arms are restrained via an interior surface of the capsule so that distal ends of the clips arms are drawn toward one another, and a reinforcement element coupled to the clip arms, the reinforcement element preventing deflection of the clip arms when engaging a target tissue.

Abstract: A medical device for treating a body lumen, such as a medical stent, includes an expandable scaffold configured to shift from a radially collapsed state to a radially expanded state. The stent includes a coating disposed along the outer surface of the expandable scaffold in which a portion of the coating includes a plurality of anti-migration members and one or more preferential separation regions. Each preferential separation region is configured to permit first and second regions of the coating to separate from one another along the preferential separation region therebetween as the expandable scaffold shifts from the radially collapsed state to the radially expanded state.

Abstract: A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

Abstract: The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to single-use endoscopic medical devices with integrated and purpose-built functionality.

Abstract: The present disclosure relates to the field of tissue closures including medical devices that close openings in tissue during a surgical procedure. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained configuration to engage tissue on opposing sides of a tissue opening, and hold opposing tissue portions together to maintain the opening in a closed configuration.

Abstract: A device includes a flexible insertion section extending from a distal end which, during use is inserted to a target site to a proximal end which remains outside the body; an end effector coupled to a distal end of the insertion section; and a control wire received within the insertion section and extending from a proximal end coupled to an actuator to a distal end coupled to the end effector. The control wire is movable within the insertion section to operate the end effector. The control wire and the insertion section include a bend in a distal portion thereof configured so that, in a resting state, the control wire and the insertion section bend through a predetermined arc at a selected bending radius. A distal portion of the control passes into and through a working channel of an insertion device without plastic deformation of the control wire.

Abstract: A medical device including a handle body having a proximal end and a distal end, a spool on the handle body and to move between the distal end and the proximal end of the handle body, a catheter extending from the distal end of the handle body, an actuator attached to the spool and extending through the catheter, such that the actuator is removably connected to one or more dispensable devices at a distal end of the catheter, a spool controller to prevent connection with another of the dispensable devices to the actuator after a predetermined number of dispensable devices have been dispensed by the medical device.

Abstract: Embodiments provide a computer-executable method, computer system and non-transitory computer-readable medium for programmatically processing text information to generate attribute descriptors contained therein. The method includes programmatically accessing, via a network device, a textual unit, the textual unit associated with a commercial entity or a commercial object. The method also includes executing a text processing engine to programmatically generate an attribute descriptor from the textual unit. The method further includes storing, on a non-transitory computer-readable storage device, the attribute descriptor in association with identification of the commercial entity or the commercial object.

Abstract: The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection.

Abstract: A system for treating tissue includes a clip assembly including a pair of clip arms, proximal ends of the clip arms slidably received within a channel of a capsule to be moved between a tissue receiving configuration and a tissue clipping configuration, an applicator including a catheter and a control member extending therethrough, a distal end of the control member configured to be connected to the clip arms to move the clip assembly between the tissue receiving and tissue clipping configurations, and a coupler releasably coupled to proximal ends of the clip arms and configured to be coupled to the distal end of the control member, the coupler configured to yield when a proximal force exerted on the coupler via the control member exceeds a first predetermined threshold value to disengage the clip arms to deploy the clip assembly.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for an adaptive oracle-trained learning framework for automatically building and maintaining models that are developed using machine learning algorithms. In embodiments, the framework leverages at least one oracle (e.g., a crowd) for automatic generation of high-quality training data to use in deriving a model. Once a model is trained, the framework monitors the performance of the model and, in embodiments, leverages active learning and the oracle to generate feedback about the changing data for modifying training data sets while maintaining data quality to enable incremental adaptation of the model.