Abstract: A system for treating tissue includes a clip assembly including a pair of clip arms, proximal ends of the clip arms slidably received within a channel of a capsule to be moved between a tissue receiving configuration and a tissue clipping configuration, and an applicator releasably coupleable to the clip assembly to move the clip assembly between the tissue receiving configuration and the tissue clipping configuration, the applicator including a control member having a plurality of nodes extending therealong, each node having a cross-sectional are larger than a cross-sectional area of a remaining portion of the control member and configured to be coupled to the proximal end of the clip arms, a distal-most one of the nodes severable from a next immediately proximal one of the nodes, when a force exerted thereon exceeds a predetermined threshold value, to release the clip assembly from the applicator.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip jaws, proximal ends of which are slidably received within the channel of the capsule so that the clip jaws are movable between an open configuration and a closed configuration. Clip jaws are configured so that a distance between the distal ends of the clip jaws in an open configuration is between 15 and 18 millimeters. Clip jaws further include barbs extending from a distal portion thereof.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for identifying a new business based on programmatically analyzing content received from online sources and, as a result, discovering one or more references to the business. In embodiments, the system stores historical data representing previously identified new businesses and then uses attributes of those businesses in search queries to receive related content. Additionally or alternatively, the system stores data representing online sources that historically provided content containing references to new businesses and then continues to access those sources for additional content. In embodiments, the system performs content analysis on structured and/or unstructured content.

Abstract: A system for treating tissue includes an applicator having a bushing and a control member and a clip assembly having a capsule with a channel extending therethrough. The channel includes proximal and distal portions. The distal portion extends distally from the proximal portion and flaring outward in a single plane to form opposing flared sections. The assembly also includes clip arms include proximal ends slidably received within the channel to move the arms between tissue receiving and tissue clipping configurations. The assembly further includes a yoke including a distal portion connected to the arms and a proximal portion configured to be connected to the member so that longitudinal movement of the member relative to the capsule moves the arms between the tissue receiving and clipping configurations. The yoke is positioned in the capsule so that the yoke is deformable in the plane in which the capsule flares outward.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for an adaptive oracle-trained learning framework for automatically building and maintaining models that are developed using machine learning algorithms. In embodiments, the framework leverages at least one oracle (e.g., a crowd) for automatic generation of high-quality training data to use in deriving a model. Once a model is trained, the framework monitors the performance of the model and, in embodiments, leverages active learning and the oracle to generate feedback about the changing data for modifying training data sets while maintaining data quality to enable incremental adaptation of the model.

Abstract: Release mechanism for medical device includes a bushing having a proximal end, a distal end and a channel extending therethrough. Plurality of extend proximally from the distal end are biased toward a release configuration in which engagement surfaces at distal ends thereof retract radially into the channel. A core pin insertable through the channel applies a radially expansive pressure to move the arms radially outward to a locking configuration. Engagement surfaces of the first and second arms connect to a retaining surface of a tissue treatment device containing capsule, which extends at an angle relative to the engagement surfaces selected so that a first portion of a force transmitted along an axis of the bushing moves the arms radially inward toward the release configuration before a second portion of the force exceeds a threshold level associated with the removal of a tissue treatment device from gripped tissue.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: A device includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough. The capsule is releasably coupled to a proximal portion of the device. Device also includes a first arm rigidly fixed to the distal end of the capsule to extend distally therefrom. In addition, Device includes a second arm, a proximal end of which is slidably received within the capsule so that the second arm is movable between an open configuration, in which the second arm is moved laterally away from the first arm and a distal end of the second arm is moved distally past the distal end of the first arm, and a closed configuration, in which the second arm is moved toward the first arm and the distal end of the second arm is moved proximally toward the distal end of the first arm.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for an adaptive oracle-trained learning framework for automatically building and maintaining models that are developed using machine learning algorithms. In embodiments, the framework leverages at least one oracle (e.g., a crowd) for automatic generation of high-quality training data to use in deriving a model. Once a model is trained, the framework monitors the performance of the model and, in embodiments, leverages active learning and the oracle to generate feedback about the changing data for modifying training data sets while maintaining data quality to enable incremental adaptation of the model.

Abstract: A system for treating tissue includes an applicator and a clip assembly. The applicator includes a catheter extending longitudinally and a lumen extending therethrough, a control member extending through the lumen of the catheter. The assembly is releasably coupleable to a distal end of the applicator. The assembly includes a pair of clip arms, proximal ends of which are slidably received within a channel of a capsule, a pair of opposing coupling elements extending proximally from the proximal ends of the arms to be fixed over the distal end of the member so that the arms are movable relative to the capsule via a longitudinal motion of the member between a tissue receiving configuration, in which distal ends of the arms are separated from one another, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another.

Abstract: A medical device including an application device with a first fluid path and a container movably attached to the application device. The container and the application device have a second fluid path therethrough, the container includes an inner chamber that is intermediate proximal and distal portions of the second fluid path, the inner chamber is fluidly isolated from the proximal portion of the second fluid path at a first position of the container, and the inner chamber is fluidly coupled to the proximal and distal portions of the second fluid path at a second position of the container. The first fluid path bypasses the container and the passage of fluid through the first fluid path is separately controllable from the passage of fluid through the second fluid path.

Abstract: A system for treating tissue includes a capsule including a channel extending therethrough; first and second clip arms each extending from a proximal end to a distal end, the proximal ends being received within the channel of a capsule to be moved between an open tissue receiving configuration; and a closed tissue clipping configuration. The first clip arm includes a first tissue retention feature at a distal portion thereof configured to pierce through a target tissue when in the tissue clipping configuration and subsequently release the target tissue when the clip arms are moved to an at least partially open configuration. The second clip arm includes a second tissue retention feature at a distal portion thereof configured to pierce and retain the target tissue thereon when in both the closed tissue clipping configuration and the open tissue receiving configuration.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip jaws, proximal ends of which are slidably received within the channel of the capsule so that the clip jaws are movable between an open configuration and a closed configuration. Clip jaws are configured so that a distance between the distal ends of the clip jaws in an open configuration is between 15 and 18 millimeters. Clip jaws further include barbs extending from a distal portion thereof.

Abstract: A system for treating tissue includes an applicator having a bushing and a control member and a clip assembly having a capsule with a channel extending therethrough. The channel includes proximal and distal portions. The distal portion extends distally from the proximal portion and flaring outward in a single plane to form opposing flared sections. The assembly also includes clip arms include proximal ends slidably received within the channel to move the arms between tissue receiving and tissue clipping configurations. The assembly further includes a yoke including a distal portion connected to the arms and a proximal portion configured to be connected to the member so that longitudinal movement of the member relative to the capsule moves the arms between the tissue receiving and clipping configurations. The yoke is positioned in the capsule so that the yoke is deformable in the plane in which the capsule flares outward.

Abstract: The present disclosure relates to the field of endoscopy. In particular, the present disclosure relates to systems and methods suitable for resecting or dissecting large areas of mucosal or submucosal tissue. The system may apply tension to and continuously manipulate mucosal tissue such that large lesions may be resected or dissected by a cutting element disposed at the distal end of an endoscope.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for automated dynamic data quality assessment. One aspect of the subject matter described in this specification includes the actions of receiving a data quality job including a new data sample; and, if the new data sample is determined to be added to a reservoir of data samples, sending a quality verification request to an oracle; receiving a new data sample quality estimate from the oracle; and adding the new data sample and estimate to the reservoir. A second aspect of the subject matter includes the actions of receiving, from a predictive model, a judgment associated with a new data sample; analyzing the new data sample based in part on the judgment to determine whether to send a new data sample quality verification request to an oracle; and, if a new data sample quality estimate is received from the oracle, determining whether to add the new data sample and the judgment to the reservoir.

Abstract: A device includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough. The capsule is releasably coupled to a proximal portion of the device. Device also includes a first arm rigidly fixed to the distal end of the capsule to extend distally therefrom. In addition, Device includes a second arm, a proximal end of which is slidably received within the capsule so that the second arm is movable between an open configuration, in which the second arm is moved laterally away from the first arm and a distal end of the second arm is moved distally past the distal end of the first arm, and a closed configuration, in which the second arm is moved toward the first arm and the distal end of the second arm is moved proximally toward the distal end of the first arm.

Abstract: A medical insertion device includes an elongated shaft extending from a proximal end to a distal end and having flexibility sufficient for insertion through a working channel of an endoscope along a tortuous path. The elongated shaft includes a coil extending from the proximal end to the distal end and having a channel extending longitudinally therethrough and a braided portion extending around a portion of the coil, the braided portion including a plurality of lines wound together such that first and second ones of the lines intersect to enclose a predetermined angle therebetween, the angle being between 25 and 55 degrees.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for curating a training data set to ensure that training data being updated continuously from a data reservoir of verified possible training examples remain an accurate, high-quality representation of the distribution of data that are being input to a predictive model for processing.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for an adaptive oracle-trained learning framework for automatically building and maintaining models that are developed using machine learning algorithms. In embodiments, the framework leverages at least one oracle (e.g., a crowd) for automatic generation of high-quality training data to use in deriving a model. Once a model is trained, the framework monitors the performance of the model and, in embodiments, leverages active learning and the oracle to generate feedback about the changing data for modifying training data sets while maintaining data quality to enable incremental adaptation of the model.