Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.

Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

Abstract: This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

Abstract: A method of providing multiple voltage references to a radio-frequency device using a single analog line includes the steps of setting the analog line voltage level to be a first reference voltage signal; instructing a first voltage reference device to memorize the first reference voltage signal by sending a first digital control signal to a digital line; providing the first reference voltage signal to the RF device via the first voltage reference device; re-setting the analog line voltage level to be a second reference voltage signal; instructing a second voltage reference device to memorize the second reference voltage signal by sending a second digital control signal to the digital line, the second digital control signal being different from the first digital control signal; and providing the second reference voltage signal to the RF device via the second voltage reference device.

Abstract: A system includes a control board, a controlled board, and a connector connecting the control board to the controlled board. The control board includes a processing unit that configures the reference voltage signals, a non-volatile memory that stores information about the reference voltage signals, and a DAC that outputs the reference voltage signals in accordance with instructions from the processing unit. The controlled board includes: first and second voltage reference devices that receive first and second reference voltage signals, respectively, and a radio-frequency device that receives a first frequency signal and a second frequency signal and outputs a third frequency signal based on one of the first and second reference voltage signals. The connector includes an analog line for providing reference voltage signals to the first and second voltage reference devices and a digital line for providing control signals to activate one of the first and second voltage reference devices.

Abstract: A transceiver used in a radio unit for wireless communication, comprises: a circuitry board including a transmitter and a receiver; a first connector on a first side of the circuitry board, wherein the first connector is configured to be connected to an interface card; a second connector on a second side of the circuitry board, wherein the second side is opposite the first side and the second connector is configured to be connected to a digital card via a flexible circuit; and a pair of transmit port and receive port located on the second side of the circuitry board, wherein the transmit port is coupled to the transmitter and the receive port coupled to the receiver, respectively. When the transceiver is part of a split-mount radio unit (SRU), the first connector is connected to the interface card and the second connector is not in use. When the transceiver is part of an all-outdoor radio unit (AOU), the second con vector is connected to the digital card and the first connector is not in use.

Abstract: A microwave radio receiver includes a first down-converter, a second down-converter, and a combined receiver signal level (RSL) and interference detector. The first down-converter is configured to convert a RF signal into a first IF signal. The second down-converter is configured to convert the first IF signal into a second IF signal. The combined RSL and interference detector is configured to determine one or more RSLs and generate an interference indicator based on the first IF signal from the first down-converter and a control signal from the second down-converter.

Abstract: An antenna RSSI meter includes a microcontroller unit for digitizing an antenna receiver voltage signal, converting the digitized antenna receiver voltage signal into a receiver signal level in accordance with a predefined antenna specification, and converting the receiver signal level into the antenna tuning signal in accordance with the predefined antenna specification. The antenna RSSI meter includes an input communication port for receiving the antenna receiver voltage signal from an antenna and providing the antenna receiver voltage signal to the microcontroller unit, The antenna RSSI meter also includes an output communication port for receiving the antenna tuning signal from the microcontroller unit and providing the antenna tuning signal to an antenna auto-aligning mechanism for adjusting position and orientation of the antenna.

Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

Abstract: This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

Abstract: A system includes a control board, a controlled board, and a connector connecting the control board to the controlled board. The control board includes a processing unit that configures the reference voltage signals, a non-volatile memory that stores information about the reference voltage signals, and a DAC that outputs the reference voltage signals in accordance with instructions from the processing unit. The controlled board includes: first and second voltage reference devices that receive first and second reference voltage signals, respectively, and a radio-frequency device that receives a first frequency signal and a second frequency signal and outputs a third frequency signal based on one of the first and second reference voltage signals. The connector includes an analog line for providing reference voltage signals to the first and second voltage reference devices and a digital line for providing control signals to activate one of the first and second voltage reference devices.

Abstract: An electric field sensor comprises an insulating substrate, a plurality of non-contacting electrodes disposed on the substrate, and a plurality of conductors coupled to the electrodes, and extending transversely through the substrate. The electrodes comprise a first electrode portion, and a second electrode portion interlaced with the first electrode portion. The conductors comprise a first conductor portion and a second conductor portion. The first portion of the conductors are coupled to the first electrode portion. The second portion of the conductors are coupled to the second electrode portion.

Abstract: This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

Abstract: An electric field sensor comprises an insulating substrate, a plurality of non-contacting electrodes disposed on the substrate, and a plurality of conductors coupled to the electrodes, and extending transversely through the substrate. The electrodes comprise a first electrode portion, and a second electrode portion interlaced with the first electrode portion. The conductors comprise a first conductor portion and a second conductor portion. The first portion of the conductors are coupled to the first electrode portion. The second portion of the conductors are coupled to the second electrode portion.

Abstract: A computer-based fibre production monitoring system includes at least one sensor, and a computer server in communication with the sensors. Each sensor is configured to provide data packets each being associated with a respective threadline and providing a measurement of at least one physical characteristic of a fibre as it is drawn past the sensor on the threadline and wound onto a bobbin. The computer server is configured to provide an analysis of the physical characteristics on a per-threadline basis and/or per-bobbin basis from the measurements. The sensor is configured as an electric field sensor, and includes an insulating substrate, non-contacting electrodes disposed on the substrate, and vias extending transversely through the substrate. The electrodes are interlaced with one another. One portion of the vias is coupled to one portion of the electrodes, and another portion of the vias is coupled to another portion of the electrodes.

Abstract: A computer-based fibre production monitoring system includes at least one sensor, and a computer server in communication with the sensors. Each sensor is configured to provide data packets each being associated with a respective threadline and providing a measurement of at least one physical characteristic of a fibre as it is drawn past the sensor on the threadline and wound onto a bobbin. The computer server is configured to provide an analysis of the physical characteristics on a per-threadline basis and/or per-bobbin basis from the measurements. The sensor is configured as an electric field sensor, and includes an insulating substrate, non-contacting electrodes disposed on the substrate, and vias extending transversely through the substrate. The electrodes are interlaced with one another. One portion of the vias is coupled to one portion of the electrodes, and another portion of the vias is coupled to another portion of the electrodes.

Abstract: A mixed voltage CMOS process for high reliability and high performance core transistors and input-output transistors with reduced mask steps. A gate stack (30) is formed over the silicon substrate (10). Ion implantation is performed of a first species and a second species to produce the doping profiles (70, 80, 90, 100) in the input-output transistors.

Abstract: This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.