Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and perform: receiving a request for an order comprising one or more items; determining when the order is eligible for batch picking by finding one or more other orders comprising at least one of the one or more items; and when the order is determined to be eligible for batch picking with the one or more other orders: creating one or more clusters by clustering together (1) the at least one of the one or more items of the order and (2) the at least one of the one or more items of the one or more other orders; estimating, for each respective cluster of the one or more clusters, an estimated fulfillment time interval to make ready the order; and assigning each respective cluster of the one or more clusters to at least one respective picker of one or more respective pickers. Other embodiments are disclosed herein.

Abstract: A system and method for identification of target sites in a pathogenic genome and combating a pathogenic infection have been provided. The present disclosure utilizes the fact that a conserved stretch of nucleotide sequence in genomic neighborhood of genes important for bacteria can be targeted to disrupt the overall functioning of the pathogen. The method involves identification of nucleotide repeat sequences in the DNA. The method and system also involve administration of a cocktail comprising antimicrobial drugs, biofilm inhibitors and a construct. The genomic neighborhood or vicinity or ‘flanking genes’ refers to regions lying within a predefined number of genes to the identified conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome or within a distance of predefined number of bases with respect to the conserved stretch of nucleotide repeat sequence (or its reverse complement) on the candidate pathogen genome.

Abstract: The invention provides a system and method for a mobile-powered desktop ECG system configured for remote monitoring of a patient. Analog ECG waveforms from probes attached to a patient are shared with a base ECG unit. The received analog ECG waveforms are converted into digital ECG waveforms and shared with a smartphone that powers the base ECG unit. The digital ECG waveforms are processed in the smartphone through an ECG application and sent to a cloud. The ECG application enables the smartphone connect with a medical practitioner in case a medical emergency is detected.

Abstract: Co-infection of Pseudomonas aeruginosa and Staphylococcus aureus, exacerbates the virulence gene expression as well as shows higher antibacterial resistance than when they cause infections individually thereby making the infection extremely difficult to combat. A method and system for combating infections due to Pseudomonas aeruginosa and Staphylococcus aureus has been provided. The system provides strategies to combat pathogenic infections caused by multi-drug resistant (MDR) and extensively drug resistant (XDR) strains of Pseudomonas aeruginosa and Staphylococcus aureus. The strategy involves identifying potential target sites, which can be utilized to compromise its multiple virulence or essential functions at the same time.

Abstract: A method includes performing a downhole operation in a borehole in a formation. Downhole particles and drilling mud are captured at a surface from the borehole into a screen of a shaker during the downhole operation. Input power that comprises at least one of voltage, current, and leakage current being supplied to the shaker is monitored during operation of the shaker, it is determined whether the input power exceeds a threshold as a result of change in a load on the shaker. In response to determining that the input power exceeds the threshold as the result of change in the load on the shaker, it is determined that there is a kick condition in the borehole, where the kick condition comprises a condition in which a pressure of the formation exceeds a pressure in the borehole.

Abstract: The present invention relates to solriamfetol or novel salts thereof and its process for preparation. More particularly the present invention relates to solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric acid salt and their process for preparation. Further the present invention relates to use of solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric acid salt for the preparation of solriamfetol hydrochloride.

Abstract: Colorectal cancer is a severe disease, if not assessed properly, it may lead to the death of an individual. A system and method for assessing the risk of colorectal cancer has been provided. The system is configured to assess individuals to check the risk of presence of colorectal cancer (CRC) and/or adenomatous (colonic/rectal) polyps, by quantifying the abundance of sensory proteins in their gut microbiome. The system further categorizes the person into one of healthy, adenoma and cancerous categories based on the nature and abundance of sensory proteins in the gut microbiome. The system further describes microbiota based therapeutics for treatment of the person with colorectal adenoma and/or cancer through administration of at least one of a consortium of healthy microbes, antibiotic drugs and pre-/pro-/syn-/post-biotic compounds or fecal microbiome transplant which could modulate the disease microbiome composition towards a healthy equilibrium.

Abstract: The onset of Parkinson's disease (PD) is a serious concern for elderly people and it is necessary to identify the risk for PD in an individual as early as possible. A system and method for risk assessment of an individual for Parkinson's disease (PD) has been provided. The system is using a non-invasive method for risk assessment of PD through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system 100 is configured to calculate a score, which is evaluated from the gut bacterial taxonomic abundance profile, which is indicative of its metabolic potential for production of a particular neuroactive compound. This score is subsequently used to assess the risk of an individual of being affected by PD. Further, the present disclosure also provides microbiome based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.

Abstract: A flow body for an aircraft includes a torsion box with spars and/or ribs and at least two skin portions for enveloping the spars and/or ribs, wherein at least one inner cell is formed in the torsion box. It is provided that a gas tank with a gas tank shell is arranged in the at least one inner cell, and that the gas tank includes fastening elements coupled to retaining elements in the relevant inner cell in order to hold the gas tank such that the gas tank shell is supported at a distance from the spars and/or ribs and the skin portions and is supported in three spatial directions.

Abstract: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease affecting brain and the spinal cord which results in distorted communication between brain and rest of the body. It is necessary to assess the risk of MS at the earliest. A system and method for diagnosis and risk assessment of an individual for multiple sclerosis has been provided. The system is using a non-invasive method for risk assessment through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system is configured to calculate a score, which is evaluated from the gut bacterial taxonomic abundance profile, indicative of its metabolic potential for production of a particular neuroactive compound. The score is subsequently used to predict the risk of the individual for MS. The present disclosure also provides microbiome based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.

Abstract: A device may receive content data identifying television schedules for content to be provided for viewing in a first geographic location and a second geographic location, and may identify a first available time slot for content in the first geographic location and a second available time slot for content in the second geographic location. The device may identify a first set of content for the first available time slot and a second set of content for the second available time slot, and may assign values to the first and second sets. The device may determine whether the values assigned to the first and second sets satisfy a threshold value, and may cause, when a value of content in the first set fails to satisfy the threshold value, a first client device, in the first geographic location, to obtain replacement content with a value that satisfies the threshold value.

Abstract: Techniques and systems for determining paywall metrics are described. In an implementation, a candidate paywall metric is created that corresponds to an increased propensity of users to engage in a paid transaction when exposed to a paywall. In this way, providers of digital content may increase the proportion of users that perform a transaction when exposed to the paywall.

Abstract: The present invention relates to a compound comprising a hydrophobic moiety, a linker and N-containing moiety. The present invention also relates to the method of synthesizing the compound and the use of the compound as an antibiotic or an adjuvant for an antibiotic.

Abstract: A system including a cooling element and an egress passageway is described. The cooling element is configured to provide a stream of hot air having been heated by a heat from a heat-generating structure. The hot air passes through the egress passageway toward an egress. The egress passageway includes at least one inlet through which cool air is drawn to be mixed with the hot air.

Abstract: A system comprises an apparatus having a nozzle. An element is arranged around the apparatus. A feeder is configured to supply a powder of a material into the apparatus. A gas source is configured to supply a precursor gas into the apparatus and to supply an inert gas to circulate through a space between the element and the apparatus and to exit around the nozzle. A plasma generator is arranged in the apparatus and is configured to ionize the precursor gas and atomize the powder and to eject through the nozzle a jet of particles composed of the atomized powder and the ionized precursor gas onto a substrate arranged adjacent to the nozzle.

Abstract: A cooling system including a heat spreader, an active cooling element, and a base is described. The heat spreader is in thermal communication with a heat-generating structure mounted on a substrate. The heat spreader over hangs the heat-generating structure. The active cooling element is in thermal communication with the heat spreader. The base supports the heat spreader and transfers a load from the heat spreader to the substrate such that a bending of the heat spreader does not exceed ten degrees.

Abstract: Embodiments disclosed herein include electronics packages with improved thermal pathways. In an embodiment, an electronics package includes a package substrate. In an embodiment, the package substrate comprises a plurality of backside layers, a plurality of front-side layers, and a core layer between the plurality of backside layers and the plurality of front-side layers. In an embodiment, an inductor is embedded in the plurality of backside layers. In an embodiment, a plurality of bumps are formed over the front-side layers and thermally coupled to the inductor. In an embodiment, the plurality of bumps are thermally coupled to the core layer by a plurality of vias.

Abstract: Methods are provided for activation of catalysts comprising low amounts of a hydrogenation metal, such as low amounts of a Group 8-10 noble metal. The amount of hydrogenation metal on the catalyst can correspond to 0.5 wt % or less (with respect to the weight of the catalyst), or 0.1 wt % or less, or 0.05 wt % or less. Prior to loading a catalyst into a reactor, the corresponding catalyst precursor can be first activated in a hydrogen-containing atmosphere containing 1.0 vppm of CO or less. The thus first-activated catalyst can be transferred to a reactor with optional exposure to oxygen during the transfer, where it can be further activated using a hydrogen-containing atmosphere containing 3.0 vppm of CO or higher, to yield a twice-activated catalyst with high performance. The catalyst can be advantageously a transalkylation catalyst or an isomerization catalyst useful for converting aromatic hydrocarbons.

Abstract: An apparatus includes a shaker screen onto which downhole materials and fluid from a borehole are to be placed, the downhole materials a product of a downhole operation and a shaker to vibrate the shaker screen to separate the downhole materials from the fluid. The apparatus includes a radar to emit an electromagnetic wave onto the downhole materials on at least one of the shaker screen and a transit and detect a reflection of the electromagnetic wave reflected off at least a portion of the downhole materials and a device to determine a velocity of the downhole materials advancing along at least one of the shaker screen toward a discharge end of the shaker screen and the transit.

Abstract: A system and method are disclosed for solving a supply chain planning problem modeled as a linear programming (LP) problem. Embodiments include receiving a matrix formulation of at least a portion of the LP problem representing a supply chain planning problem for a supply chain network, generating an image based on the matrix formulation to identify connected components, partitioning the matrix formulation based, at least in part, on the connected components constraint into at least two partitions, formulating an LP subproblem from each of the at least two partitions, and solving the LP subproblems to generate a global solution to the supply chain planning problem.