Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: The present Application is related to methods and compositions for reprogramming adult somatic cells into induced pluripotent stem cells by targeting and remodeling endogenous gene loci without relying on ectopic expression of transcription factors.

Abstract: An image construction method and system for a heating area is provided. The method includes: obtaining an initial image according to a heating structure diagram and a building structure diagram of the heating area; segmenting the initial image according to heating attribute of the heating area to obtain a plurality of segmentation sub-graphs; performing first collection on a surface temperature of a heating pipeline according to pre-deployed surface devices corresponding to the segmentation sub-graphs, and setting first heating labels corresponding to the segmentation sub-graphs, and meanwhile, performing second collection on a regional temperature of a sub-area of the heating pipeline being located according to a pre-deployed monitoring device corresponding to the segmentation sub-graphs, and setting second heating labels; performing position and temperature analysis on a label setting result of each of the segmentation sub-graphs to obtain a heating image of the heating area.

Abstract: A suture needle guide tube includes a tube body and a suture needle guide. The tube body includes an internal axial channel for arranging a handling tube and a plurality of suture needle passing paths located in different positions for guiding a suture needle to pass therethrough. The suture needle guide includes a plurality of suture needle guide channels. Each suture needle guide channel communicates with the corresponding suture needle passing path to guide the suture needle out of the suture needle guide channel, through the suture needle passing path, and into an inner cavity and to allow the suture needle to exit with a suture.

Abstract: The present invention discloses an electric folding vehicle, including a front wheel frame, a first vehicle frame, a second vehicle frame, a chair frame, and a linkage mechanism. The linkage mechanism includes a first linkage rod with a first end rotatably connected to the front wheel frame and a second end rotatably connected to the second vehicle frame, and a second linkage rod with a first end rotatably connected to the second end of the first linkage rod and a second end connected to the chair frame. By providing a linkage mechanism, when the first vehicle frame and the second vehicle frame are folded and collapsed, the present invention can drive the front wheel frame to fold synchronously with the chair frame, so as to achieve rapid folding and collapsing of the electric folding vehicle, and make the electric folding vehicle more convenient to carry.

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: A male single-pin connector is provided. The single-pin connector includes a contact, which has a contact housing, wherein the contact housing has at least one limiting protrusion on an outer surface; and a cover for receiving the contact, wherein the inner surface of the cover has an inwardly protruding limiting portion and an internal thread portion, wherein the internal thread portion is closer to the insertion side than the limiting portion; wherein the male single-pin connector also includes a retaining ring having an outer thread portion, wherein, after insertion of the contact housing into the cover against the plug-in direction, the retaining ring is screwed into the cover until the limiting protrusion comes into contact with the limiting portion, thereby fixing the contact housing in the cover by a screw connection. A female multi-pin connector and a connector system is also provided.

Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.

Abstract: An image construction method and system for a heating area is provided. The method includes: obtaining an initial image according to a heating structure diagram and a building structure diagram of the heating area; segmenting the initial image according to heating attribute of the heating area to obtain a plurality of segmentation sub-graphs; performing first collection on a surface temperature of a heating pipeline according to pre-deployed surface devices corresponding to the segmentation sub-graphs, and setting first heating labels corresponding to the segmentation sub-graphs, and meanwhile, performing second collection on a regional temperature of a sub-area of the heating pipeline being located according to a pre-deployed monitoring device corresponding to the segmentation sub-graphs, and setting second heating labels; performing position and temperature analysis on a label setting result of each of the segmentation sub-graphs to obtain a heating image of the heating area.

Abstract: A socket module includes a positioning seat, a live wire conductive sheet, a neutral wire conductive sheet, a ground wire conductive sheet, and a fixing seat. The live wire conductive sheet, the neutral line conductive sheet, and the ground wire conductive sheet are installed on the positioning seat and then assembled into the fixing seat to form an integrated socket module. The socket module has a live wire slot hole corresponding the live wire conductive sheet, a neutral wire slot hole corresponding to the neutral wire conductive sheet, and a ground wire slot hole corresponding to the ground wire conductive sheet in three different directions. The socket module can be installed in single or multiple socket housings to realize a small-sized multi-slot socket that is compact, safe and reliable.

Abstract: The present Application is related to methods and compositions for reprogramming adult somatic cells into induced pluripotent stem cells by targeting and remodeling endogenous gene loci without relying on ectopic expression of transcription factors.

Abstract: The present invention relates to a 3CL protease small-molecule inhibitor for treating or preventing a coronavirus infection, and the use thereof. Specifically, the present invention relates to a compound of formula (I) or an isotopically labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer, or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof, and the use thereof in the preparation of a drug for treating or preventing a coronavirus infection or a disease or symptom caused by a coronavirus.

Abstract: Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.

Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.

Abstract: Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these antibodies, and related compositions and methods.

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

Abstract: A heavy-duty plug-in connector has a ground terminal that can be conveniently assembled and can comprise the greatest possible number of electrical crimp plug-in contacts (4,5). For this purpose, ground plug-in contacts (4?, 5?), likewise of a crimping configuration, are fitted in formations (13, 13?, 23, 23?) of the contact carriers (1, 2) for electrical contacting with metallic protective earthing elements (3, 3?, 3?, 3??). For said contacting, the formations (13, 13?, 23, 23?) have a respective opening (130, 130?) or passage (230, 230?). In the formations (13, 13?, 23, 23?), not only ground plug-in contacts (4?, 5?) but also further plug-in contacts (4, 5) are arranged, so that the number of plug-in contacts (4, 5) of the plug-in connector is increased considerably.