Abstract: An application of a Bacillus Calmette-Guérin (BCG)-based outer membrane vesicle (OMV) trained immunity inducer in preparation of an immunotherapeutic drug for sepsis is provided. The disclosure isolates and collects OMVs secreted by BCG bacteria to obtain a BCG-based OMV trained immunity inducer (designated as B-OMVs). The B-OMVs combines distinct advantages of both BCG and OMVs while circumventing their respective drawbacks. The developed B-OMVs exhibits characteristics such as being non-replicative, non-infectious, and of low toxicity, resulting in minimal impact on the organism and high safety. In addition, the B-OMVs demonstrates a more moderate yet effective immunomodulatory capacity. It can induce trained immunity, enhance the body's resistance to microbial infections, reduce the need for antibiotics, and more effectively improve the prognosis of sepsis.

Abstract: A cartridge body of a staple cartridge includes a tissue contact platform; a plurality of staple cavities; and a retaining pin assembly slidably arranged in an end of the cartridge body proximate to the outside. In the longitudinal direction of the staple cartridge, an outermost edge of an outermost staple cavity in at least one row of the staple cavities is aligned with or extends beyond a longitudinal axis of the pin rod. The A surgical stapler includes an anvil for causing staples in the staple cartridge formed and an anvil side retaining pin receiving hole for receiving a free end of a retaining pin assembly of the staple cartridge. An outermost edge of an outermost staple forming pocket in at least one row of the staple forming pockets is aligned with or extends beyond a center of the retaining pin receiving hole at the anvil side.

Abstract: A surgical instrument includes a lockout assembly that can be unlocked by a surgical staple cartridge. The lockout assembly prevents a pair of closure plates and a firing bar of the surgical instrument from advancing distally when in a locked position, and allows the pair of closure plates and the firing bar to advance distally when in an unlocked position.

Abstract: The present invention relates compounds for stabilizing cells and methods of their use.

Abstract: The invention relates to a combination of small molecule reprogramming agents for inducing the generation of totipotent stem cells, a method for preparing the induced totipotent stem cells and the induced totipotent stem cells generated therefrom.

Abstract: A socket module includes a positioning seat, a live wire conductive sheet, a neutral wire conductive sheet, a ground wire conductive sheet, and a fixing seat. The live wire conductive sheet, the neutral line conductive sheet, and the ground wire conductive sheet are installed on the positioning seat and then assembled into the fixing seat to form an integrated socket module. The socket module has a live wire slot hole corresponding the live wire conductive sheet, a neutral wire slot hole corresponding to the neutral wire conductive sheet, and a ground wire slot hole corresponding to the ground wire conductive sheet in three different directions. The socket module can be installed in single or multiple socket housings to realize a small-sized multi-slot socket that is compact, safe and reliable.

Abstract: The present disclosure provides a surgical instrument, which comprises a lockout assembly that can be unlocked by a surgical staple cartridge, wherein the lockout assembly prevents a pair of closure plates and a firing bar of the surgical instrument from advancing distally when in a locked position, and allows the pair of closure plates and the firing bar to advance distally when in an unlocked position.

Abstract: Provided is use of a compound shown in formula I, formula I? or formula I?, and tautomers, stereoisomers, or pharmaceutically acceptable salts of the three compounds as METTL3 inhibitors. The compounds have good regulatory and inhibitory effects on METTL3/METTL14 and AML related cell lines. In terms of enzyme and cell activity, they have obvious advantages compared with compounds disclosed in the prior art (under the same Assay, the enzyme and cell activity of the compounds provided by the present disclosure are significantly improved compared with similar compounds in the prior art). Therefore, the compounds provided by the present disclosure can be used for treating symptoms and diseases associated with the methyltransferase activity of METTL3/METTL14. In addition, preparation methods of the compounds provided by the present disclosure are simple and have good application prospects.

Abstract: A surgical staple cartridge includes installation poka-yoke features. The surgical staple cartridge is configured to be installed between a pair of closure plates of a surgical instrument. The closure plates are configured to push the surgical staple cartridge towards a staple anvil portion of the surgical instrument to clamp tissue between the surgical staple cartridge and the staple anvil portion. The surgical staple cartridge includes two opposite side walls extending in a longitudinal direction parallel to an installation direction of the surgical staple cartridge. A protrusion and/or a slot are provided on an outer surface of at least one of the side walls. The protrusion as well as the slot are configured to cooperate with corresponding features on the closure plates, so as to prevent an inappropriate installation of the surgical staple cartridge.

Abstract: The present disclosure relates to a surgical stapler and a staple cartridge for use with the surgical stapler, where a cartridge body of the staple cartridge includes: a tissue contact platform; a plurality of staple cavities arranged in rows along a longitudinal direction of the staple cartridge; and a retaining pin assembly slidably arranged in an end of the cartridge body proximate to the outside and can extend distally out of a retaining pin hole opened on the tissue contact platform along a longitudinal direction of the surgical stapler when the closure drive mechanism is actuated, wherein a pin rod of the retaining pin assembly having a round cross section; wherein, in the longitudinal direction of the staple cartridge, an outermost edge of an outermost staple cavity in at least one row of the staple cavities is aligned with or extends beyond a longitudinal axis of the pin rod; and wherein the pin rod of the retaining pin assembly is offset relative to a longitudinal centerline of the staple cartridge;

Abstract: A method for treating a disease associated with cell autophagy functional deficiency and/or lysosomal functional deficiency, such as neurodegenerative diseases, by inhibiting KEAP1 activity and/or enhancing the expression of nuclear erythroid 2-related factor 2 (NRF2) and/or the downstream genes thereof. The expression of NRF2 and/or the downstream genes thereof is enhanced with a KEAP1 inhibitor, a KEAP1 gene knockdown, and/or an NRF2 activator. The method and product can increase the acidic environment in the lysosomes of neurons, increase the enzymatic activity of cathepsins, decrease the abnormal storage of proteins, protect mitochondrial homeostasis in neurons, and increase the capability of mitochondria to generate ATP.

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: The present Application is related to methods and compositions for reprogramming adult somatic cells into induced pluripotent stem cells by targeting and remodeling endogenous gene loci without relying on ectopic expression of transcription factors.

Abstract: An image construction method and system for a heating area is provided. The method includes: obtaining an initial image according to a heating structure diagram and a building structure diagram of the heating area; segmenting the initial image according to heating attribute of the heating area to obtain a plurality of segmentation sub-graphs; performing first collection on a surface temperature of a heating pipeline according to pre-deployed surface devices corresponding to the segmentation sub-graphs, and setting first heating labels corresponding to the segmentation sub-graphs, and meanwhile, performing second collection on a regional temperature of a sub-area of the heating pipeline being located according to a pre-deployed monitoring device corresponding to the segmentation sub-graphs, and setting second heating labels; performing position and temperature analysis on a label setting result of each of the segmentation sub-graphs to obtain a heating image of the heating area.

Abstract: A suture needle guide tube includes a tube body and a suture needle guide. The tube body includes an internal axial channel for arranging a handling tube and a plurality of suture needle passing paths located in different positions for guiding a suture needle to pass therethrough. The suture needle guide includes a plurality of suture needle guide channels. Each suture needle guide channel communicates with the corresponding suture needle passing path to guide the suture needle out of the suture needle guide channel, through the suture needle passing path, and into an inner cavity and to allow the suture needle to exit with a suture.

Abstract: The present invention discloses an electric folding vehicle, including a front wheel frame, a first vehicle frame, a second vehicle frame, a chair frame, and a linkage mechanism. The linkage mechanism includes a first linkage rod with a first end rotatably connected to the front wheel frame and a second end rotatably connected to the second vehicle frame, and a second linkage rod with a first end rotatably connected to the second end of the first linkage rod and a second end connected to the chair frame. By providing a linkage mechanism, when the first vehicle frame and the second vehicle frame are folded and collapsed, the present invention can drive the front wheel frame to fold synchronously with the chair frame, so as to achieve rapid folding and collapsing of the electric folding vehicle, and make the electric folding vehicle more convenient to carry.

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.

Abstract: A socket module includes a positioning seat, a live wire conductive sheet, a neutral wire conductive sheet, a ground wire conductive sheet, and a fixing seat. The live wire conductive sheet, the neutral line conductive sheet, and the ground wire conductive sheet are installed on the positioning seat and then assembled into the fixing seat to form an integrated socket module. The socket module has a live wire slot hole corresponding the live wire conductive sheet, a neutral wire slot hole corresponding to the neutral wire conductive sheet, and a ground wire slot hole corresponding to the ground wire conductive sheet in three different directions. The socket module can be installed in single or multiple socket housings to realize a small-sized multi-slot socket that is compact, safe and reliable.