Abstract: Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these antibodies, and related compositions and methods.

Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A self-adaptive constant-current driving circuit for a three-channel multi-color LED, including a decoder, a two-phase non-overlapping circuit, and a LED constant-current driving circuit, where the decoder determines the number of lighted channels according to a first input signal, and generates a first switch control signal and a second switch control signal; the two-phase non-overlapping circuit modulates the first switch control signal into a first two-phase non-overlapping signal and a second two-phase non-overlapping signal, and modulates the second switch control signal into a third two-phase non-overlapping signal and a fourth two-phase non-overlapping signal; the LED constant-current driving circuit controls an on/off state of the respective channel of LED according to a second input signal, and outputs a current for controlling a brightness of the respective channel of LED according to the first two-phase non-overlapping signal, the second two-phase non-overlapping signal, the third two-phase non-ove

Abstract: A method and apparatus for neural network based cross component prediction with scaling factors during encoding or decoding of an image frame or a video sequence, which may include training a deep neural network (DNN) cross component prediction (CCP) model with at least one or more scaling factors, wherein the at least one or more scaling factors are learned by optimizing a rate-distortion loss based on an input video sequence comprising a luma component, and reconstructing a chroma component based on the luma component using the trained DNN CCP model with the at least one or more scaling factors for chroma prediction. The trained DNN CCP may be updated for chroma prediction of the input video sequence using the one or more scaling factors, and performing chroma prediction of the input video sequence using the updated DNN CCP model with the one or more scaling factors.

Abstract: Embodiments provide a method of performing a carrier switch for a device wafer, attaching a second wafer and removing a first wafer. A buffer layer is deposited over the device wafer, buffer layer reducing the topography of the surface of the device wafer. After the carrier switch a film-on-wire layer is removed from the buffer layer and then the buffer layer is at least in part removed.

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract: A first polymer layer is formed across a package region and a test region. A first metal pattern is formed in the package region and a first test pattern is simultaneously formed in the test region. The first metal pattern has an upper portion located on the first polymer layer and a lower portion penetrating through the first polymer layer, and the first test pattern is located on the first polymer layer and has a first opening exposing the first polymer layer. A second polymer layer is formed on the first metal pattern in the package region and a second test pattern is simultaneously formed on the first test pattern in the test region. The second polymer layer has a second opening exposing the upper portion of the first metal pattern, and the second test pattern has a third opening greater than the first opening of the first test pattern.

Abstract: Aspects of the disclosure provide a method and an apparatus for video encoding. The apparatus includes processing circuitry configured to generate an initial feature representation from an input image to be encoded and perform an iterative update of values of a plurality of elements in the initial feature representation. The iterative update includes generate a coded representation corresponding to a final feature representation based on the final feature representation that has been updated from the initial feature representation by a number of iterations of the iterative update. A reconstructed image corresponding to the final feature representation is generated based on the coded representation. An encoded image corresponding to the final feature representation having updated values of the plurality of elements is generated. One of (i) a rate-distortion loss corresponding to the final feature representation or (ii) the number of iterations of the iterative update satisfies a pre-determined condition.

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

Abstract: Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these antibodies, and related compositions and methods.

Abstract: A heavy-duty plug-in connector has a ground terminal that can be conveniently assembled and can comprise the greatest possible number of electrical crimp plug-in contacts (4,5). For this purpose, ground plug-in contacts (4?, 5?), likewise of a crimping configuration, are fitted in formations (13, 13?, 23, 23?) of the contact carriers (1, 2) for electrical contacting with metallic protective earthing elements (3, 3?, 3?, 3??). For said contacting, the formations (13, 13?, 23, 23?) have a respective opening (130, 130?) or passage (230, 230?). In the formations (13, 13?, 23, 23?), not only ground plug-in contacts (4?, 5?) but also further plug-in contacts (4, 5) are arranged, so that the number of plug-in contacts (4, 5) of the plug-in connector is increased considerably.

Abstract: Etoposide glycosides and methods of making etoposide glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to etoposide to yield etoposide glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

Abstract: Enasidenib glycosides and methods of making enasidenib glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to enasidenib to yield enasidenib glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, galacturonate, glucose, glucuronic acid, mannose, N-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

Abstract: Ivacaftor glycosides and methods of making ivacaftor glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to ivacaftor to yield ivacaftor glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

Abstract: A heavy-duty plug-in connector has a ground terminal that can be conveniently assembled and can comprise the greatest possible number of electrical crimp plug-in contacts (4,5). For this purpose, ground plug-in contacts (4?, 5?), likewise of a crimping configuration, are fitted in formations (13, 13?, 23, 23?) of the contact carriers (1, 2) for electrical contacting with metallic protective earthing elements (3, 3?, 3?, 3?). For said contacting, the formations (13, 13?, 23, 23?) have a respective opening (130, 130?) or passage (230, 230?). In the formations (13, 13?, 23, 23?), not only ground plug-in contacts (4?, 5?) but also further plug-in contacts (4, 5) are arranged, so that the number of plug-in contacts (4, 5) of the plug-in connector is increased considerably.

Abstract: Described herein a polycistronic expression cassettes and expression vectors that include a promoter operably linked to a nucleic acid segment that encodes a Sox2 and Klf4 polypeptide. The nucleic acid segment can also encode a c-Myc polypeptide. Expression of such polycistronic expression cassettes/vectors in host cells can reprogram the host cells to stem cells or other types of reprogrammed cells.

Abstract: A heavy-duty plug-in connector has a ground terminal that can be conveniently assembled and can comprise the greatest possible number of electrical crimp plug-in contacts (4,5). For this purpose, ground plug-in contacts (4?, 5?), likewise of a crimping configuration, are fitted in formations (13, 13?, 23, 23?) of the contact carriers (1, 2) for electrical contacting with metallic protective earthing elements (3, 3?, 3?, 3??). For said contacting, the formations (13, 13?, 23, 23?) have a respective opening (130, 130?) or passage (230, 230?). In the formations (13, 13?, 23, 23?), not only ground plug-in contacts (4?, 5?) but also further plug-in contacts (4, 5) are arranged, so that the number of plug-in contacts (4, 5) of the plug-in connector is increased considerably.

Abstract: Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.