Abstract: A tissue closure device includes: a tube body with a plurality of needle outlet channels; a plurality of suture needles located in the tube body; and a needle manipulator disposed on the tube body and movable between a needle initial position and a needle triggering position. The needle manipulator drives the suture needles to simultaneously extend obliquely from respective corresponding needle outlet channels to a puncture position. The needle manipulator allows the suture needles to simultaneously retract into the respective corresponding needle outlet channels. The needle manipulator can thus drive in one step the suture needles to the puncture position, so that the consistency and symmetry of the puncture position can be improved, and the deviation of the puncture position can be avoided, to avoid the risk of damaging other organs around tissue when the suture needles puncture the tissue, thereby improving the safety of surgical suturing.

Abstract: A tissue closure device includes a main body housing and an access needle. A suture slot and a needle exit hole are provided on a sidewall of the main body housing. The access needle can be preloaded in a chamber, and is provided with a suture carrying portion. When the access needle is in an initial position, the access needle is accommodated in the chamber, and the suture carrying portion and the suture slot are at least partially communicated such that a suture can enter the suture carrying portion via the suture slot. In a suture loading process, the tip of the access needle is concealed in the main body housing, so that an operator can be protected from a puncture wound, and the tip of the access needle is less likely to be contaminated.

Abstract: A tissue closure device includes a main body housing, an access needle, and a needle control component. The needle control component is mounted to the main body housing and fixedly connected to the access needle, and the needle control component can hold the access needle in an initial position in a predetermined orientation and can drive the access needle to move from the initial position to an actuated position at a predetermined depth. The needle control component in can achieve accurate control over the retention and actuation processes of the access needle as such an integrated unit, such that an operator can conveniently load a suture when the access needle is held in the initial position; and the access needle has better depth and rotation accuracy during actuation, so as to accurately carry the suture to a predetermined position.

Abstract: The present invention discloses an experimental apparatus and a method for measuring swimming features of algal cells in a shear flow, wherein the experimental apparatus comprises an air pressure source, a pressure pump, a liquid storage bottle, a flow meter, a microchannel and a waste liquid bottle which are connected in sequence; the method comprises: determining an average flow rate according to the experimental conditions to produce a stable shear flow; capturing an image sequence of the movement track of algal cells; and observing the movement track of algae cells to obtain the distribution of an algae cell migration velocity V, obtain the distribution of an algae cell flow velocity Vflow by combining the analytic method, and then obtain the swimming features of the algae cells in the shear flow, comprising a swimming velocity Vs and an angular velocity ? of the algae cells.

Abstract: The present invention discloses an electric folding vehicle, including a front wheel frame, a first vehicle frame, a second vehicle frame, a chair frame, and a linkage mechanism. The linkage mechanism includes a first linkage rod with a first end rotatably connected to the front wheel frame and a second end rotatably connected to the second vehicle frame, and a second linkage rod with a first end rotatably connected to the second end of the first linkage rod and a second end connected to the chair frame. By providing a linkage mechanism, when the first vehicle frame and the second vehicle frame are folded and collapsed, the present invention can drive the front wheel frame to fold synchronously with the chair frame, so as to achieve rapid folding and collapsing of the electric folding vehicle, and make the electric folding vehicle more convenient to carry.

Abstract: Described herein a polycistronic expression cassettes and expression vectors that include a promoter operably linked to a nucleic acid segment that encodes a Sox2 and Klf4 polypeptide. The nucleic acid segment can also encode a c-Myc polypeptide. Expression of such polycistronic expression cassettes/vectors in host cells can reprogram the host cells to stem cells or other types of reprogrammed cells.

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract: A surgical staple cartridge includes installation poka-yoke features. The surgical staple cartridge is configured to be installed between a pair of closure plates of a surgical instrument. The closure plates are configured to push the surgical staple cartridge towards a staple anvil portion of the surgical instrument to clamp tissue between the surgical staple cartridge and the staple anvil portion. The surgical staple cartridge includes two opposite side walls extending in a longitudinal direction parallel to an installation direction of the surgical staple cartridge. A protrusion and/or a slot are provided on an outer surface of at least one of the side walls. The protrusion as well as the slot are configured to cooperate with corresponding features on the closure plates, so as to prevent an inappropriate installation of the surgical staple cartridge.

Abstract: An application of a Bacillus Calmette-Guérin (BCG)-based outer membrane vesicle (OMV) trained immunity inducer in preparation of an immunotherapeutic drug for sepsis is provided. The disclosure isolates and collects OMVs secreted by BCG bacteria to obtain a BCG-based OMV trained immunity inducer (designated as B-OMVs). The B-OMVs combines distinct advantages of both BCG and OMVs while circumventing their respective drawbacks. The developed B-OMVs exhibits characteristics such as being non-replicative, non-infectious, and of low toxicity, resulting in minimal impact on the organism and high safety. In addition, the B-OMVs demonstrates a more moderate yet effective immunomodulatory capacity. It can induce trained immunity, enhance the body's resistance to microbial infections, reduce the need for antibiotics, and more effectively improve the prognosis of sepsis.

Abstract: A cartridge body of a staple cartridge includes a tissue contact platform; a plurality of staple cavities; and a retaining pin assembly slidably arranged in an end of the cartridge body proximate to the outside. In the longitudinal direction of the staple cartridge, an outermost edge of an outermost staple cavity in at least one row of the staple cavities is aligned with or extends beyond a longitudinal axis of the pin rod. The A surgical stapler includes an anvil for causing staples in the staple cartridge formed and an anvil side retaining pin receiving hole for receiving a free end of a retaining pin assembly of the staple cartridge. An outermost edge of an outermost staple forming pocket in at least one row of the staple forming pockets is aligned with or extends beyond a center of the retaining pin receiving hole at the anvil side.

Abstract: A surgical instrument includes a lockout assembly that can be unlocked by a surgical staple cartridge. The lockout assembly prevents a pair of closure plates and a firing bar of the surgical instrument from advancing distally when in a locked position, and allows the pair of closure plates and the firing bar to advance distally when in an unlocked position.

Abstract: The present invention relates compounds for stabilizing cells and methods of their use.

Abstract: The invention relates to a combination of small molecule reprogramming agents for inducing the generation of totipotent stem cells, a method for preparing the induced totipotent stem cells and the induced totipotent stem cells generated therefrom.

Abstract: A socket module includes a positioning seat, a live wire conductive sheet, a neutral wire conductive sheet, a ground wire conductive sheet, and a fixing seat. The live wire conductive sheet, the neutral line conductive sheet, and the ground wire conductive sheet are installed on the positioning seat and then assembled into the fixing seat to form an integrated socket module. The socket module has a live wire slot hole corresponding the live wire conductive sheet, a neutral wire slot hole corresponding to the neutral wire conductive sheet, and a ground wire slot hole corresponding to the ground wire conductive sheet in three different directions. The socket module can be installed in single or multiple socket housings to realize a small-sized multi-slot socket that is compact, safe and reliable.

Abstract: The present disclosure provides a surgical instrument, which comprises a lockout assembly that can be unlocked by a surgical staple cartridge, wherein the lockout assembly prevents a pair of closure plates and a firing bar of the surgical instrument from advancing distally when in a locked position, and allows the pair of closure plates and the firing bar to advance distally when in an unlocked position.

Abstract: Provided is use of a compound shown in formula I, formula I? or formula I?, and tautomers, stereoisomers, or pharmaceutically acceptable salts of the three compounds as METTL3 inhibitors. The compounds have good regulatory and inhibitory effects on METTL3/METTL14 and AML related cell lines. In terms of enzyme and cell activity, they have obvious advantages compared with compounds disclosed in the prior art (under the same Assay, the enzyme and cell activity of the compounds provided by the present disclosure are significantly improved compared with similar compounds in the prior art). Therefore, the compounds provided by the present disclosure can be used for treating symptoms and diseases associated with the methyltransferase activity of METTL3/METTL14. In addition, preparation methods of the compounds provided by the present disclosure are simple and have good application prospects.

Abstract: A surgical staple cartridge includes installation poka-yoke features. The surgical staple cartridge is configured to be installed between a pair of closure plates of a surgical instrument. The closure plates are configured to push the surgical staple cartridge towards a staple anvil portion of the surgical instrument to clamp tissue between the surgical staple cartridge and the staple anvil portion. The surgical staple cartridge includes two opposite side walls extending in a longitudinal direction parallel to an installation direction of the surgical staple cartridge. A protrusion and/or a slot are provided on an outer surface of at least one of the side walls. The protrusion as well as the slot are configured to cooperate with corresponding features on the closure plates, so as to prevent an inappropriate installation of the surgical staple cartridge.

Abstract: The present disclosure relates to a surgical stapler and a staple cartridge for use with the surgical stapler, where a cartridge body of the staple cartridge includes: a tissue contact platform; a plurality of staple cavities arranged in rows along a longitudinal direction of the staple cartridge; and a retaining pin assembly slidably arranged in an end of the cartridge body proximate to the outside and can extend distally out of a retaining pin hole opened on the tissue contact platform along a longitudinal direction of the surgical stapler when the closure drive mechanism is actuated, wherein a pin rod of the retaining pin assembly having a round cross section; wherein, in the longitudinal direction of the staple cartridge, an outermost edge of an outermost staple cavity in at least one row of the staple cavities is aligned with or extends beyond a longitudinal axis of the pin rod; and wherein the pin rod of the retaining pin assembly is offset relative to a longitudinal centerline of the staple cartridge;

Abstract: A method for treating a disease associated with cell autophagy functional deficiency and/or lysosomal functional deficiency, such as neurodegenerative diseases, by inhibiting KEAP1 activity and/or enhancing the expression of nuclear erythroid 2-related factor 2 (NRF2) and/or the downstream genes thereof. The expression of NRF2 and/or the downstream genes thereof is enhanced with a KEAP1 inhibitor, a KEAP1 gene knockdown, and/or an NRF2 activator. The method and product can increase the acidic environment in the lysosomes of neurons, increase the enzymatic activity of cathepsins, decrease the abnormal storage of proteins, protect mitochondrial homeostasis in neurons, and increase the capability of mitochondria to generate ATP.