Patents by Inventor Sheng Ding

Sheng Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • An Embedded High Voltage LDMOS-SCR Device with a Strong Voltage Clamp and ESD Robustness
    Publication number: 20190006344
    Abstract: The present invention provides an embedded high voltage LDMOS-SCR device with strong voltage clamp and ESD robustness, which can be used as the on-chip ESD protection for high voltage IC. Wherein said the device comprises a P substrate, a P well, a N well, a first field oxide isolation region, a first P+ injection region, a second field oxide isolation region, a first N+ injection region, a first fin polysilicon gate, a second N+ injection region, a second fin polysilicon gate, a third N+ injection region, a third fin polysilicon gate, a polysilicon gate, a fourth fin polysilicon gate, a second P+ injection region, a fifth fin polysilicon gate, a third P+ injection region, a sixth fin polysilicon gate, a fourth P+ injection region, a third oxygen isolation region, a fourth N+ injection region and a fourth field oxygen isolation region.
    Type: Application
    Filed: March 11, 2016
    Publication date: January 3, 2019
    Inventors: Hailian LIANG, Huyun LIU, Xiaofeng GU, Sheng DING
  • Reprogramming fibroblasts into cardiomyocytes
    Patent number: 10144915
    Abstract: Compositions and methods are described herein for chemically inducing cells that express a single pluripotency transcription factor to change their differentiation state and become cardiac cells, cardiac progenitor cells, cardiomyocytes, or a combination thereof.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: December 4, 2018
    Assignee: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
    Inventors: Haixia Wang, Sheng Ding
  • METHOD FOR PREPARING ITRACONAZOLE PREPARATION
    Publication number: 20180263912
    Abstract: A method for preparing an itraconazole formulation including: dissolving a mixture of itraconazole and L-ascorbic acid with a mixed solvent of dichloromethane and methanol, adding a hydroxypropyl methylcellulose and a pluronic F-127 and then dichloromethane into the mixed solvent to obtain a raw material solution; feeding a carbon dioxide into a crystallization autoclave in a supercritical fluid crystallization equipment system through a pressure regulating valve; spraying the solution into the crystallization autoclave via a spray nozzle, separating out composite particles from the solution and collecting the composite particles at a bottom of the crystallization autoclave, and encapsulating the composite particles to obtain a itraconazole formulation with decreased particle size and increased bioavailability.
    Type: Application
    Filed: September 8, 2015
    Publication date: September 20, 2018
    Applicants: CHANGZHOU PHARMACEUTICAL FACTORY CO., LTD., CRYSTEC LTD.
    Inventors: Xuezhi YIN, Linda Sharon DAINTREE, Sheng DING, Daniel Mark LEDGER, Bing WANG, Wenwen ZHAO, Wei WU, Jiansheng HAN
  • Methods and Compositions for Producing Pancreatic Beta Cells
    Publication number: 20180216076
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Inventors: Matthias Hebrok, Holger Andreas Russ, Sheng Ding, Saiyong Zhu
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180171303
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20180163181
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: January 19, 2018
    Publication date: June 14, 2018
    Inventors: Tongxiang Lin, Sheng Ding
  • Methods for reprogramming differentiated non-cardiac cells into cardiomyocytes
    Patent number: 9982231
    Abstract: Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become cardiac progenitor cells or cardiomyocytes.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: May 29, 2018
    Assignee: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
    Inventors: Nan Cao, Sheng Ding
  • METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS
    Publication number: 20180127712
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Application
    Filed: January 5, 2018
    Publication date: May 10, 2018
    Inventors: Yue Xu, Sheng Ding
  • METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSION MODULATION
    Publication number: 20180125847
    Abstract: Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject.
    Type: Application
    Filed: March 28, 2016
    Publication date: May 10, 2018
    Applicants: University of Washington, The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Glads
    Inventors: Thomas A. Reh, Paul Nakamura, Sheng Ding
  • TARGETED XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20180125988
    Abstract: The present disclosure provides drug conjugate compositions, and compositions and methods for preparing and using the same. In some embodiments, the present invention relates to targeted conjugate compositions comprising cysteine-containing domains (CCD) linked to targeting moieties, extended recombinant polypeptides (XTEN)and peptide cleavable moieties, with pharmacologically active payload drugs cross-linked to cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods of making the targeted conjugate compositions and methods of using the targeted conjugate compositions.
    Type: Application
    Filed: November 11, 2015
    Publication date: May 10, 2018
    Inventors: Fan YANG, Volker SCHELLENBERGER, Sheng DING, Desiree THAYER, Chia-Wei WANG
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9926533
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: March 27, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Induction of pluripotent cells
    Patent number: 9909105
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 6, 2018
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • Generating definitive endoderm and pancreatic progenitor cells
    Patent number: 9909104
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of definitive endoderm cells, posterior foregut-like progenitor cells, pancreatic progenitor cells and/or pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: March 6, 2018
    Assignee: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
    Inventors: Sheng Ding, Ke Li, Saiyong Zhu
  • Methods of enhancing cell survival of stem cells
    Patent number: 9896655
    Abstract: The present invention relates compounds for stabilizing cells and methods of their use.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: February 20, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yue Xu, Sheng Ding
  • COMPOUNDS AND METHODS FOR INDUCING BROWNING OF WHITE ADIPOSE TISSUE
    Publication number: 20180037556
    Abstract: The present invention provides a compound for inducing browning of white adipose tissue in vitro and in vivo of formula I, the preparation method thereof, as well as a composition comprising the same. Further, the present invention also relates to the use of the compound and the method to treat metabolic disorders, such as obesity and diabetes.
    Type: Application
    Filed: February 17, 2015
    Publication date: February 8, 2018
    Inventors: Baishan JIANG, Tao NIE, Wenling ZHAO, Yali ZOU, Qiang DING, Sheng DING, Donghai WU
  • Methods for Modulating Genome Editing
    Publication number: 20180016601
    Abstract: Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome editing to correct a mutation in a target gene associated with the genetic disease. Further provided herein are systems and methods for screening small molecule libraries to identify novel modulators of genome editing. The present invention can be used with any cell type and at any gene locus that is amenable to nuclease-mediated genome editing technology.
    Type: Application
    Filed: July 13, 2017
    Publication date: January 18, 2018
    Inventors: Lei S. Qi, Sheng Ding, Chen Yu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180002671
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 4, 2018
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • REPROGRAMMING CELLS
    Publication number: 20170283776
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: April 17, 2017
    Publication date: October 5, 2017
    Inventors: Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9771563
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 26, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • GENERATION AND MAINTENANCE OF STEM CELLS
    Publication number: 20170260502
    Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 14, 2017
    Inventors: Wenlin Li, Sheng Ding