Patents by Inventor Sheng Ding

Sheng Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Modulating Genome Editing
    Publication number: 20180016601
    Abstract: Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome editing to correct a mutation in a target gene associated with the genetic disease. Further provided herein are systems and methods for screening small molecule libraries to identify novel modulators of genome editing. The present invention can be used with any cell type and at any gene locus that is amenable to nuclease-mediated genome editing technology.
    Type: Application
    Filed: July 13, 2017
    Publication date: January 18, 2018
    Inventors: Lei S. Qi, Sheng Ding, Chen Yu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180002671
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 4, 2018
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • REPROGRAMMING CELLS
    Publication number: 20170283776
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Application
    Filed: April 17, 2017
    Publication date: October 5, 2017
    Inventors: Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9771563
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 26, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • GENERATION AND MAINTENANCE OF STEM CELLS
    Publication number: 20170260502
    Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 14, 2017
    Inventors: Wenlin Li, Sheng Ding
  • Generation and maintenance of stem cells
    Patent number: 9695395
    Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: July 4, 2017
    Assignee: The Scripps Research Institute
    Inventors: Wenlin Li, Sheng Ding
  • REPROGRAMMING OF CELLS TO A NEW FATE
    Publication number: 20170159019
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 8, 2017
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • Reprogramming cells
    Patent number: 9657274
    Abstract: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3?-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 23, 2017
    Assignee: The Scripps Research Institute
    Inventors: Saiyong Zhu, Sheng Ding
  • Plunger type safety valve
    Patent number: 9631733
    Abstract: A plunger type safety valve includes a valve body, a valve rod, and a tube piece. The valve body is provided with a first water inlet port and a first water outlet port, the first water inlet port is connected to a water pipe of a local water supply plant, while the first water outlet port is connected to a water input end of a filtering device. The valve rod is disposed vertically in an inner chamber of the valve body, to switch between connection and disconnection of the first water inlet port and the first water outlet port. And the tube piece is connected fixedly with a lower end of the valve body, to form into a chamber body, and is provided with a second water inlet port and a second water outlet port.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 25, 2017
    Assignee: XIAMEN RUNNER INDUSTRIAL CORPORATION
    Inventors: Bo-huang Liu, Yong-sheng Ding, Wei-qiang Xu
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170081640
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • GENERATING HEPATOCYTES
    Publication number: 20170073636
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • Inhibitors of JMJD2C as Anticancer Agents
    Publication number: 20170044107
    Abstract: The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (CRPC). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 16, 2017
    Inventors: Min Xie, Sheng Ding
  • Reprogramming of cells to a new fate
    Patent number: 9556417
    Abstract: The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: January 31, 2017
    Assignee: The Scripps Research Institute
    Inventors: Jem A. Efe, Janghwan Kim, Saiyong Zhu, Simon Hilcove, Sheng Ding
  • INDUCING BROWN FAT FATE AND FUNCTION
    Publication number: 20170014455
    Abstract: Methods and compositions are described herein for generating brown adipose cells and tissues that involve contacting one or more starting cells with bexarotene, ciclopirox, IOX2, or combinations thereof. When administered in vivo, subjects receiving bexarotene, ciclopirox, IOX2, or combinations thereof have reduced white adipose tissue mass (with enhanced beige features) as well as enlarged brown fat tissue compared to a control mammal that did not receive the bexarotene, ciclopirox, IOX2, or combinations thereof. The subjects also have increased energy expenditure, generate more heat, and/or consume more oxygen, than a control mammal that did not receive the bexarotene, ciclopirox, IOX2, or combinations thereof.
    Type: Application
    Filed: March 12, 2015
    Publication date: January 19, 2017
    Inventors: Baoming Nie, Sheng Ding
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9540615
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 10, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9534205
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: January 3, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20160369244
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 22, 2016
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Generating hepatocytes
    Patent number: 9512406
    Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
    Type: Grant
    Filed: December 20, 2014
    Date of Patent: December 6, 2016
    Assignees: The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of California
    Inventors: Saiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
  • PLUNGER TYPE SAFETY VALVE
    Publication number: 20160305560
    Abstract: A plunger type safety valve, includes a valve body, a valve rod, and a tube piece. The valve body is provided with a first water inlet port and a first water outlet port, the first water inlet port is connected to a water pipe of a local water supply plant, while the first water outlet port is connected to a water input end of a filtering device. The valve rod is disposed vertically in an inner chamber of the valve body, to switch between connection and disconnection of the first water inlet port and the first water outlet port. And the tube piece is connected fixedly with a lower end of the valve body, to form into a chamber body, and is provided with a second water inlet port and a second water outlet port.
    Type: Application
    Filed: January 19, 2016
    Publication date: October 20, 2016
    Inventors: Bo-huang Liu, Yong-sheng Ding, Wei-qiang Xu
  • WATER FILTERING DEVICE SAFETY VALVE
    Publication number: 20160305561
    Abstract: A water filtering device safety valve, comprising: a valve body, provided with a first water inlet port and a second water inlet port, and a first water outlet port and a second water outlet port; a valve core; a central valve rod, connected rigidly to a lower portion of the valve core; a water stop pad, disposed in a lower portion inner chamber of the valve body, and can be slid upward or downward; a cone shape head, disposed in a lower portion of the water stop pad; a pressure release through hole, disposed in a central portion of the water stop pad, a lower portion of the central valve rod is disposed over and opposite to the pressure release through hole; and a separation body, used to separate an upper portion inner chamber and a lower portion inner chamber of the valve body.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 20, 2016
    Inventor: Yong-sheng Ding