Abstract: Stand-alone microsystems adapted for performing combinatorial detection of bioagents at single molecule level wherein the microsystems are featured with three-dimensional microarray and multi-layer microfluidics to thereby provide high throughput screening and high content screening sufficient to allow for substantially real-time performance of the microsystem. Methods for detection of bioagents at a single molecule level or single organism level include providing a reconfigurable microsystem adapted for performing combinatorial detection of bioagents at a single molecule level and reconfiguring the reconfigurable microsystem for various environments.

Abstract: A hinge device includes a driven block (3), a cam (4), and a spring (7). The driven block includes two protrusions (31) projecting upwardly and downwardly respectively, the cam defines two opposite concave grooves (41) and two opposite arms (42), and the spring presses the driven block and the cam. Interfaces of the driven block (3) and the arms of the cam are plane surfaces, so that when the protrusions of the driven block are located on the plane surfaces, the hinge device is held in a steady state by the spring.