Abstract: A novel cationic lipid has a structure as represented by general formula (1) and specifically relates to a nitrogen-branched cationic lipid, and a liposome containing the cationic lipid, and a nucleic-acid pharmaceutical composition containing the liposome, a preparation method and application thereof, wherein, the definition of each symbol in the formula (1) is as defined herein. The cationic liposome containing the cationic lipid as represented by formula (1) can improve the loading rate and transport efficiency of nucleic-acid drugs. The formulation of the cationic liposome nucleic-acid pharmaceutical composition has good cell compatibility and higher gene transfection capability, and can improve the treatment and/or prevention effects of nucleic-acid drugs.

Abstract: End-to-end neural image compression using deep reinforcement learning (DRL) is performed by at least one processor and includes encoding an input, generating encoded representations of the input, generating a set of quantization keys using a first neural network, based on a set of previous quantization states, wherein each quantization key in the set of quantization keys and each previous quantization state in the set of previous quantization states correspond to the encoded representations of the input, generating a set of dequantized numbers representing dequantized representations of the encoded representations of the input, based on the set of quantization keys, using a second neural network, and generating a reconstructed output, based on the set of dequantized numbers.

Abstract: An improved method for preparing polyethylene glycol acetal and aldehyde derivative, and the polyethylene glycol acetal derivative is represented by formula (1) or formula (2) used to preparing a series of linear and nonlinear polyethylene glycolaldehyde derivatives with a single aldehyde group or multiple aldehyde groups, and with high yield, high purity and high terminal substitution, using a small-molecule cyclic acetal derivative and a polyethylene glycol derivative as raw materials in the presence of a base reagent derivative.

Abstract: Provided are an LDO circuit having a current limiting function, and a chip and an electronic device. The LDO circuit comprises a bandgap reference circuit (101), an error amplifier (102), a power transistor (103), a feedback resistor network (104), and a current limiting function module (105), wherein the current limiting function module (105) comprises a load current mirror unit (107), a reference current unit (108), a current comparison unit (109), a hysteresis shaping unit (110), and a control current output unit (111). The current limiting function module (105) controls the on or off of a negative feedback loop and a current limiting output unit in the LDO circuit by comparing a load current with a reference current, so as to control an output current, thereby providing a stable direct current bias voltage for a radio frequency chip under working conditions such as large power and a complex application environment.

Abstract: A venous interventional integrated device for a brain tissue biopsy or a brain-computer interface electrode placement via cerebral surface veins includes a catheter and a deformable balloon, the catheter is connected to the proximal end of the balloon, the catheter includes at least three channels: a balloon inflation channel, a guide channel, and a working channel, the balloon inflation channel is connected to the balloon lumen to inflate the balloon by injecting contrast agent, the guide channel passes through the balloon lumen from the proximal end of the balloon and exits from the distal end of the balloon for threading a micro-guidewire, the working channel extends from the sidewall of the catheter at a set distance from the proximal end of the balloon, and a puncture needle is threaded through the working channel and configured for biopsy sampling or electrode placement on the surface or deep within the brain tissue.

Abstract: Disclosed are a self-adaptive fast-response LDO circuit and a chip thereof. Said circuit includes a band gap reference circuit, an error amplifier, a power tube, a feedback resistor network, and a self-adaptive acceleration response circuit. The current of the power tube is mirrored by means of the self-adaptive acceleration response circuit, such that the tail current of a differential circuit in the error amplifier can accelerate charging and discharging adaptively according to load changes of the LDO circuit. In addition, before the LDO circuit is stably balanced, the characteristics of unbalanced states of two differential input ends of the error amplifier are used to perform fast charging and discharging on the tail current of the differential circuit and a gate electrode of the power tube in an extremely short time, such that the response time of the LDO circuit is greatly reduced.

Abstract: A novel amino acid-based cationic lipid contains unsaturated bonds, represented by the general formula (1). The amino acids or derivatives used as starting materials in the preparation process are simple and easily obtainable, offering simplicity, safety, and cost-effectiveness. The amino acid-based cationic lipid of this invention features unsaturated hydrocarbon tails and a tertiary amine moiety derived from an amino acid residue. The lipid nanoparticles (LNPs) prepared from this lipid exhibit enhanced membrane fluidity, which improves membrane fusion and facilitates cellular uptake. As a result, the delivery efficiency of the amino acid-based cationic lipid containing unsaturated bonds as a delivery material is significantly improved.

Abstract: Embodiments relate to a multi-mode demosaicing circuit able to receive and demosaic image data in a different raw image formats, such as Bayer raw image format and Quad Bayer raw image format. The multi-mode demosaicing circuit demosaics Quad Bayer image data by interpolating a green channel of the image data along each of a plurality of directions, generating a gradient of the image data along each of the plurality of directions, modifying the interpolated green channels based on respective gradients to generate full-resolution green channel image data, which is combined with red and blue image data to generate the demosaiced image data. Interpolation is performed for non-green pixels based on neighboring green pixels along a specified direction, modified by a residual value based upon valued of one or more nearby same-color pixels and a correlation between values of the same color pixels and neighboring green pixels.

Abstract: An LDO circuit having a power supply rejection function, a chip, and a communication terminal. The LDO circuit includes a bandgap reference module provided with an intermediate frequency zero adjustment unit, an amplification module provided with an intermediate frequency zero generation unit, and a power output module. The bandgap reference module is connected to the amplification module, and the amplification module is connected to the power output module. For the purpose of power supply rejection at an intermediate frequency, the intermediate frequency zero adjustment unit in the bandgap reference module and the intermediate frequency zero generation unit in the LDO circuit are adjusted in coordination to better optimize the intermediate frequency power supply rejection performance.

Abstract: Systems and methods for deep neural network (DNN)-based cross component prediction are provided. A method includes inputting a reconstructed luma block of an image or video into a DNN; and predicting, by the DNN, a reconstructed chroma block of the image or video based on the reconstructed luma block that is input. Luma and chroma reference information and side information may also be input into the DNN to predict the reconstructed chroma block. The various inputs may also be generated using processes such as downsampling and transformation.

Abstract: Video processing with a multi-quality loop filter using a multi-task neural network is performed by at least one processor and includes generating a first set of masked weight parameters, based on an input and a plurality of quantization parameter values with a corresponding first set of masks and first plurality of weight parameters, for a first set of shared neural network layers, selecting a second set of task specific neural network layers for the plurality of quantization parameter values with a second plurality of weight parameters, based on the plurality of quantization parameter values, computing an inference output, based on the first set of masked weight parameters and the second plurality of weight parameters, and outputting the computed inference output as an enhanced result.

Abstract: The present invention discloses a non-linear PEGylated lipid, including the structure represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1 and L2 are linking bonds or divalent linking groups; Lx, Y, and Ld are divalent linking groups; R1 and R2 are C4-50 hydrocarbon groups or C4-50 residues of hydrocarbon derivative containing 1-4 heteroatoms; X is —CH< or n1, n2, and n3 are integers in the range of 4-250; T is a terminal group. Compared with linear PEGylated lipids, the non-linear PEGylated lipid provided herein can realize better protective effects toward the modified LNPs. The lipid pharmaceutical composition of the present invention exhibits high efficiency of drug encapsulation, appropriate particle size, non-toxicity, and good stability in serum. The LNP-nucleic acid pharmaceutical composition of the present invention demonstrates an excellent ability to complex with nucleic acids and shows high transfection activity.

Abstract: A foveated down sampling and correction (FDS-C) circuit for combined down sampling and correction of chromatic aberrations in images. The FDS-C circuit performs down sampling and interpolation of pixel values of a first subset of pixels of a color in a raw image using down sampling scale factors and first interpolation coefficients to generate first corrected pixel values for pixels of the color in a first corrected version of the raw image. The FDS-C circuit further performs interpolation of pixel values of a second subset of the pixels in the first corrected version using second interpolation coefficients to generate second corrected pixel values for pixels of the color in a second corrected version of the raw image. Pixels in the first subset are arranged in a first direction, pixels in the second subset are arranged in a second direction, and the down sampling scale factors vary along the first direction.

Abstract: Disclosed are a radio frequency switch circuit, a chip, and a communication terminal. In the radio frequency switch circuit, a switch chain is formed by at least one switch unit being provided between a first port and a second port; each switch unit is connected to a first bias circuit and to a second bias circuit; further adjustments are made to the ratio of the parasitic capacitance between MOS transistors of each switch unit to a third capacitance; and adjustments are made to the size of said MOS transistors as well as to the ratio of said size to the third capacitance. In this way, voltage distribution uniformity on the switch chain may be improved, thus increasing the overall voltage withstand ability of the radio frequency switch circuit, and reducing the occurrence of harmonic events.

Abstract: Disclosed in the present invention are a chip port state detection circuit, a chip, and a communication terminal. The chip port state detection circuit, by means of a port detection conversion circuit, converts the state of a port to be detected into a corresponding voltage and respectively outputs same to a first comparator and a second comparator, which, after comparing same with a corresponding input reference voltage, output a logic signal to a chip ID determination circuit to obtain a chip ID corresponding to the state of the chip port to be detected, in order to distinguish multiple identical chips.

Abstract: A high-ductility battery aluminum foil and preparation method thereof are disclosed. The high-ductility battery aluminum foil includes a first component and a second component. The first component includes Si, Fe, and Cu. The second component is Al. In a cross-section of the high ductility battery aluminum foil, a presence of iron-containing second phase with an equivalent circular diameter of 0.2˜3 ?m is in a range of 1.1×102˜4×104 particles/mm2. A presence of metal intermetallic compounds, with an equivalent circular diameter of 0.2˜3 ?m, formed by Si and Cu respectively with Al, is not greater than 1.1×102 particles/mm2. A presence of elemental silicon particles, with an equivalent circular diameter of 0.2˜3 ?m, is not greater than 1.1×102 particles/mm2. The high-ductility battery aluminum foil has a thickness not greater than 13 ?m, a tensile strength not less than 250 MPa, and an elongation not less than 5%.

Abstract: A non-linear PEGylated lipid of the Formula (1) contains a tertiary amine; wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld, and Lx are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivatives, each containing 0-10 heteroatoms; y is 2 or 3; X is C or CH; XPEG is a polyethylene glycol component. Compared with linear PEGylated lipids, the PEGylated lipid can realize better surface modification of LNP, better protective effects, extended systemic circulation of LNP, and significantly reduced biological toxicity of LNP. The LNP pharmaceutical composition shows excellent drug delivery capabilities. The lipid-nucleic acid pharmaceutical composition and its formulation exhibit higher pharmaceutical efficacy, especially the LNP-nucleic acid pharmaceutical composition.

Abstract: This disclosure relates generally to audio coding and particularly to methods and systems for audio coding based on neural networks. In particular, feature vectors generated by a neural network audio encoder may be quantized using adaptive codebooks and/or grouped codebooks. Correspondingly, the encoded bitstream may be processed via a dequantization process using the adaptive codebooks and/or grouped codebooks.

Abstract: A nitrogen-branched non-linear PEGylated lipid containing a tertiary amine, which is represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld and Lx are linking bonds or divalent linking groups L; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ncore is a multivalent group of valence y+1 and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; XPEG are polyethylene glycol components. Compared with linear PEGylated lipids, the nitrogen-branched PEGylated lipid herein can realize better surface modification of LNP. The present invention also provides a lipid pharmaceutical composition and its formulation containing the PEGylated lipid, which can enhance the targeting ability of drugs and improve the transfection efficiency of nucleic acid drugs.

Abstract: A nitrogen-branched non-linear PEGylated lipid of Formula (1), wherein, X is —CRa< or (Ra is H or a C1-12 alkyl group); B1 and B2 are linking bonds or C1-20 alkylene groups; L1 and L2 are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ld is a linking bond or a divalent linking group; Ncore is a multivalent group of valence y+1, and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; Lx is a linking bond or a divalent linking group; XPEG is a polyethylene glycol component. The non-linear PEGylated lipid herein can realize better surface modification of LNP. The lipid nanoparticle pharmaceutical composition and its formulation exhibit higher drug efficacy, especially for nucleic acid drugs.