Abstract: A central lock comprises a center pole (2), a center top cap (1), and a center bottom cap (3). A locking piece (4) is received in the center bottom cap (3); a first through hole (41) is provided in the locking piece (4); and the end part of the center pole (2) is provided with a clamping groove (21) and a clamp locking part (22) located at the lower end of the clamping groove (21). When the central lock is in a locked state, the locking piece (4) is clamped with the clamping groove (21) of the center pole (2), and the locking part (22) abuts against a lower end surface of the locking piece (4); and when the central lock is in an unlocked state, the locking piece (4) is separated from the clamping groove (21), and the clamp locking part (22) can pass through the first through hole (41).

Abstract: A collapsible canopy frame with an improved locking mechanism. The collapsible canopy frame has at least three supporting legs. The collapsible canopy frame also has a central lock that is used for locking the collapsible canopy frame in an unfolded state and permits the collapsible canopy frame to be folded into a folded state when the central lock is unlocked. An outer retractable unit is connected between each adjacent supporting leg. An inner retractable unit having an inner end is connected between each supporting leg and the central lock. The inner end of the inner retractable unit is connected through the central lock.

Abstract: A collapsible canopy frame includes a plurality of side and central supports and a plurality of telescopic legs. A single activation feature provides for the extension and retraction, and the locking and unlocking of the canopy frame. A fixed bracket and a sliding bracket located at the upper end of each telescopic leg provide the connection of the telescopic legs to the side and central supports and to each other. The single activation feature includes an upper and a lower hub and when they joined together facilitate the extension and locking of canopy frame; as the lower hub is disengaged from the upper hub, the gazebo frame becomes unlocked and capable of being retracted. Each telescopic leg includes a plurality of telescopic sections that extend and retract through a cable system or a tape-driven system connected to the sliding bracket and which links the telescopic sections to each other.

Abstract: The invention belongs to the technical field of organic synthetic drugs, and particularly relates to a pyrazolopyrimidine derivative and a preparation method and medical uses thereof. The invention provides a new pyrazolopyrimidine derivative mainly having position 4 substituted, i.e., position substituted by Y in formula I. The pyrazolopyrimidine derivative of the invention has a structural formula I as follows: The invention provides a new pyrazolopyrimidine derivative and a simple, efficient and low-cost preparation method thereof. The pyrazolopyrimidine derivative of the invention has good inhibitory activity for multiple kinases, has inhibitory action on multiple solid tumors, leukemia and autoimmune diseases, provides a new effective choice for preparation of kinase inhibitors, medicines for autoimmune diseases, angiogenesis inhibitors and antitumor drugs, and has good application prospect.

Abstract: The present invention relates to the field of chemical and medicine, more particularly, 3-ethynylpyrazolopyrimidine derivatives and their preparation methods and uses. The invention provides a 3-ethynylpyrazolopyrimidine derivative, and the structure is shown in formula I. The present invention also provides preparation methods and use of 3-ethynylpyrazolopyrimidine derivatives, comprising the compounds and derivatives, and their pharmaceutical compositions for the use of the treatment and prevention of tumors.

Abstract: A collapsible canopy frame includes a plurality of side and central supports and a plurality of telescopic legs. A single activation feature provides for the extension and retraction, and the locking and unlocking of the canopy frame. A fixed bracket and a sliding bracket located at the upper end of each telescopic leg provide the connection of the telescopic legs to the side and central supports and to each other. The single activation feature includes an upper and a lower hub and when they joined together facilitate the extension and locking of canopy frame; as the lower hub is disengaged from the upper hub, the gazebo frame becomes unlocked and capable of being retracted. Each telescopic leg includes a plurality of telescopic sections that extend and retract through a cable system or a tape-driven system connected to the sliding bracket and which links the telescopic sections to each other.

Abstract: The invention belongs to the technical field of organic synthetic drugs, and particularly relates to a pyrazolopyrimidine derivative and a preparation method and medical uses thereof. The invention provides a new pyrazolopyrimidine derivative mainly having position 4 substituted, i.e., position substituted by Y in formula I. The pyrazolopyrimidine derivative of the invention has a structural formula I as follows: The invention provides a new pyrazolopyrimidine derivative and a simple, efficient and low-cost preparation method thereof. The pyrazolopyrimidine derivative of the invention has good inhibitory activity for multiple kinases, has inhibitory action on multiple solid tumors, leukemia and autoimmune diseases, provides a new effective choice for preparation of kinase inhibitors, medicines for autoimmune diseases, angiogenesis inhibitors and antitumor drugs, and has good application prospect.

Abstract: Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).

Abstract: Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).