Abstract: The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiments, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.

Abstract: An improved robotic device motion planning system that is capable of producing motion plans for accomplishing a task that are deterministic and at a higher success rate than typical systems is described herein. For example, the improved robotic device motion planning system may implement a hybrid motion planning approach in which the robotic device motion planning system initially attempts to develop a motion plan for a robotic device using a real-time motion planning algorithm. If the robotic device motion planning system is unable to develop a motion plan using a real-time motion planning algorithm, then the robotic device motion planning system may attempt to develop the motion plan using a sampling method.

Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.

Abstract: The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.

Abstract: The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Abstract: A method for determining a trajectory of a vehicle within a physical space based at least on an aligned point cloud may include generating a fused feature map by concatenating a first feature map corresponding to a source point cloud and a second feature map corresponding to a target point cloud. A machine learning model may be applied to determine, based at least on the fused feature map, a relative transform aligning the target point cloud to the source point cloud. An aligned target point cloud may be generated by transforming the target point cloud in accordance with the relative transform. Furthermore, a trajectory of a vehicle within the physical space may be determined based on at least the first relative transform. Related systems and computer program products are also provided.

Abstract: The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.

Abstract: A method for determining a trajectory of a vehicle within a physical space based at least on an aligned point cloud may include generating a fused feature map by concatenating a first feature map corresponding to a source point cloud and a second feature map corresponding to a target point cloud. A machine learning model may be applied to determine, based at least on the fused feature map, a relative transform aligning the target point cloud to the source point cloud. An aligned target point cloud may be generated by transforming the target point cloud in accordance with the relative transform. Furthermore, a trajectory of a vehicle within the physical space may be determined based on at least the first relative transform. Related systems and computer program products are also provided.

Abstract: A method for determining a trajectory of a vehicle within a physical space based at least on an aligned point cloud may include generating a fused feature map by concatenating a first feature map corresponding to a source point cloud and a second feature map corresponding to a target point cloud. A machine learning model may be applied to determine, based at least on the fused feature map, a relative transform aligning the target point cloud to the source point cloud. An aligned target point cloud may be generated by transforming the target point cloud in accordance with the relative transform. Furthermore, a trajectory of a vehicle within the physical space may be determined based on at least the first relative transform. Related systems and computer program products are also provided.

Abstract: The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.

Abstract: Compositions and methods for the treatment of benign nervous system tumors including schwannomas using attenuated Salmonella typhimurium and optionally one or more checkpoint inhibitors.

Abstract: A radar target simulator for simulating radar targets is provided. The radar target simulator has an analogue-to-digital converter having a first clock generator and a digital-to-analogue converter having a second clock generator. The analogue-to-digital converter is configured to receive a radar signal transmitted by a radar system as an input signal, while the digital-to-analogue converter is configured to return an output signal to the radar system for simulation of the radar target. Further, the first and the second clock generator are configured to operate the analogue-to-digital converter and the digital-to-analogue converter at a different sampling rate in each case.

Abstract: Various embodiments of the present invention are directed toward systems and methods relating to security screening. For example, a screening system includes a chamber configured to accommodate a user to be screened, and a chamber scanner. The chamber scanner is configured to scan the user to identify whether the user is carrying an undivested item that needs to be divested. The chamber is configured to release the user to proceed from the chamber to a secure area, upon confirmation that no undivested items are to be divested.

Abstract: A radar target simulation device for testing a device under test with respect to at least one radar scenario. The radar target simulation device includes a memory, a radar scenario simulator and at least two antennas. The memory stores the radar scenario(s) with respect to the device under test, and provides the radar scenario(s) to the radar scenario simulator. The radar scenario simulator receives radar signals from the device under test via the antennas to simulate the radar scenario(s) by manipulating the radar signals according to the radar scenario(s), generates resulting manipulated radar signals, and transmits the manipulated radar signals to the device under test via the antennas. The memory contains storage contents including storage cells, wherein each storage cell corresponds to the respective antenna of the at least two antennas.

Abstract: A system for parallel measurement of devices under test in an open over the air environment is provided. The system comprises a plurality of alignment structures, each comprising a shaped reflector arranged at a top end of the alignment structure and an antenna arranged at the focal region of the shaped reflector. In this context, the devices under test are arranged at bottom ends of the plurality of alignment structures, opposite to a respective shaped reflector. In addition, the plurality of alignment structures are placed parallel to each other without shielded enclosures.

Abstract: A system for parallel measurement of devices under test in an open over the air environment is provided. The system comprises a plurality of alignment structures, each comprising a shaped reflector arranged at a top end of the alignment structure and an antenna arranged at the focal region of the shaped reflector. In this context, the devices under test are arranged at bottom ends of the plurality of alignment structures, opposite to a respective shaped reflector. In addition, the plurality of alignment structures are placed parallel to each other without shielded enclosures.

Abstract: Systems and methods for systems and methods for generating the complete set of IC design layout clips, or any part of the complete set, satisfying usefulness criteria and of a prespecified size. A method includes generating an initial set of integrated circuit (IC) design layout clips as a current set of IC design layout clips. The method includes removing any of IC design layout clips from the current set of IC design layout clips that do not meet the one or more usefulness criteria. The method includes, while a size of the IC design layout clips is less than a desired clip size, generating a new set of IC design layout clips from the current set of IC design layout clips according to every combination of pairs of the design layout clips in the current set of IC design layout clips, and repeating the removing process.

Abstract: Systems and methods for systems and methods for generating the complete set of IC design layout clips, or any part of the complete set, satisfying usefulness criteria and of a prespecified size. A method includes generating an initial set of integrated circuit (IC) design layout clips as a current set of IC design layout clips. The method includes removing any of IC design layout clips from the current set of IC design layout clips that do not meet the one or more usefulness criteria. The method includes, while a size of the IC design layout clips is less than a desired clip size, generating a new set of IC design layout clips from the current set of IC design layout clips according to every combination of pairs of the design layout clips in the current set of IC design layout clips, and repeating the removing process.

Abstract: A method and a system for detecting faulty devices are provided. The method comprises the steps of gathering test data in near field with respect to a device under test, extrapolating the test data to far field conditions with the aid of at least one machine learning technique, and evaluating a far field performance of the device under test on the basis of the far field conditions.