Abstract: Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.

Abstract: A package structure and a method of forming the same are provided. The package structure includes a first die, a second die, a first encapsulant, and a buffer layer. The first die and the second die are disposed side by side. The first encapsulant encapsulates the first die and the second die. The second die includes a die stack encapsulated by a second encapsulant encapsulating a die stack. The buffer layer is disposed between the first encapsulant and the second encapsulant and covers at least a sidewall of the second die and disposed between the first encapsulant and the second encapsulant. The buffer layer has a Young's modulus less than a Young's modulus of the first encapsulant and a Young's modulus of the second encapsulant.

Abstract: Disclosed are methods and compositions for treating cell proliferative diseases and disorders such as cancers. Particularly disclosed are methods and composition for treating cancers such as glioblastoma by administering a therapeutic agent that inhibits the biological activity of the autophagy related 4B cysteine peptidase (ATG4B) protein in conjunction with additional therapeutic agents or treatments.

Abstract: A method and an apparatus for controlling a mobile robot, and a control system are provided. The method includes: in response to receiving a start request sent by a mobile robot, obtaining at least one of the position information or condition information of the mobile robot; determining a speed limit value of the mobile robot according to the obtained information; and sending a start instruction including the speed limit value to the mobile robot, so as to control the mobile robot to move at a speed smaller than or equal to the speed limit value. The implementation improves the motion safety of a mobile robot.

Abstract: A remote control method for an autonomous vehicle includes: a central control device receives a remote control request message sent by a vehicle; detects a driving operation of a control person on the simulated cockpit; generates an instruction for simulating a driving operation according to the driving operation of a control person on the simulated cockpit, where the instruction for simulating a driving operation is used to simulate the driving operation of the control person on the simulated cockpit; and sends a remote control message to the vehicle. A remote control apparatus for an autonomous vehicle is also related.

Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody Y126C and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, most of mice do not show toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.

Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, most of the mice show no toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.

Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-tetrodotoxin humanized antibody and use thereof. The humanized antibody has a heavy-chain variable region and a light-chain variable region with amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 2, respectively. Affinity analysis shows that the antibody of the present disclosure has prominent affinity. It is proved by experiments that, after mice in an antibody protection group pre-injected with the antibody of the present disclosure are injected with tetrodotoxin, no mice shows toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the antibody of the present disclosure shows excellent anti-tetrodotoxin effects, excellent preventive or therapeutic effects on puffer fish-related biological injuries, and promising clinical application prospects.

Abstract: The present disclosure provides a method and an apparatus for remotely controlling a self-driving vehicle, including: a control device receives operation state information of the vehicle to be controlled transmitted by the vehicle, and video data and/or audio data of a passenger in the vehicle; determines a first abnormal parameter of the vehicle according to the operation state information of the vehicle; determines a second abnormal parameter of an emotion of the passenger in the vehicle according to the video data and/or audio data of the passenger in the vehicle; and controls the vehicle remotely according to the first abnormal parameter and the second abnormal parameter. It is possible to avoid the situation that the passenger in the vehicle performs a wrong manipulation on the vehicle due to a large emotional fluctuation in an emergency, thus making the control of the vehicle more safe and reliable in the emergency.

Abstract: A chimeric antigen receptor (CAR) cell library is established through the fusion of a cell and a vector assembly. The vector assembly carries three genetic elements corresponding to a plurality of first genetic elements encoding one or more idiotype CARs, a second genetic element carrying one or more genetic circuits, and a third genetic element encoding one or more inducible proteins, respectively. The one or more genetic circuits are pre-programmed and are each a combination of a cis-regulatory factor and a transcription factor; and the one or more inducible proteins include one or two selected from the group consisting of a drug resistance protein and a suicide protein. By designing a CAR library-genetic circuit-inducible protein coupling scheme, the cell library construction and screening for complex and unknown disease target antigens are realized, such as to solve the problems that there are complex, diverse, and variable antigens.

Abstract: A soluble dimeric immunoadhesin includes a dimerized first polypeptide chain and a dimerized second polypeptide chain. The first polypeptide chain has a general formula of Z1-Z2, and the second polypeptide chain has a general formula of Y1-Y2. Z1 is (i) an extracellular domain of a first cell surface receptor or a functional variant or fragment thereof, or (ii) a first cytokine or a functional variant or fragment thereof; Z2 is a dimerization domain of an immunoglobulin constant region or a functional variant or fragment thereof. Y1 is an extracellular domain of a second cell surface receptor or a functional variant or fragment thereof, or (ii) a second cytokine or a functional variant or fragment thereof. Y2 is a dimerization domain of an immunoglobulin constant region or a functional variant or fragment thereof. A dimeric protein can be used for the treatment and prevention of infertility-related diseases.

Abstract: A method, an apparatus and a control system for controlling a mobile robot are provided. The method includes: receiving a motion mode change request sent by a target mobile robot, the motion mode change request including motion mode information, and the motion mode information being information of a motion mode to be obtained by change requested by the target mobile robot; determining whether the target mobile robot has a permission to move in the motion mode; and sending motion confirmation information for the motion mode change request to the target mobile robot to control the target mobile robot to move in the motion mode, in response to determining that the target mobile robot has the permission.

Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-physaliatoxin nanobody, and a preparation method and use thereof. The nanobody is a VHH antibody with an amino acid sequence shown in SEQ ID NO. 1. Affinity analysis shows that the nanobody of the present disclosure has prominent affinity. It is proved by small animal experiments that, after mice in an antibody protection group pre-injected with the nanobody of the present disclosure are injected with physaliatoxin, no mice shows toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the nanobody of the present disclosure shows excellent anti-physaliatoxin effects, excellent preventive or therapeutic effects on jellyfish stings, and promising clinical application prospects.

Abstract: The present disclosure provides a remote control method, apparatus, device and computer readable storage medium, the method including: receiving, by a cloud server, a control instruction transmitted from a third-party device, the control instruction comprising a vehicle identification and operation information; and transmitting the control instruction to an unmanned vehicle corresponding to the vehicle identification according to the vehicle identification, enabling the unmanned vehicle to act on the operation information. By establishing a communication connection between the third-party device, the unmanned vehicle and the cloud server, remote maneuvering of the unmanned vehicle can be implemented, a flexibility in controlling the unmanned vehicle improved.

Abstract: Use of an exosome derived from decidual natural killer (dNK) cells or a dNK cell subset in the preparation of a drug and an auxiliary therapeutic agent for infertility-related diseases is provided. Experiments have confirmed that the exosome treats the endometrial growth disorder-related diseases by promoting increase of endometrial thickness, increasing endometrial cell viability, reducing endometrial cell damage, promoting VEGF expression, and maintaining stemness and stimulating proliferation of endometrial stromal cells, such that a conception rate for endometrial injury model mice increases from 20% to 50%-70%; and the exosome treats the maternal-fetal immune tolerance disorder-related diseases by exerting immune tolerance, reducing a spontaneous abortion rate, and increasing a helper T cell level.

Abstract: A method and an apparatus for controlling an autonomous vehicle are provided according to the embodiments of the disclosure. The method includes: sending, in response to determining that a pedestrian is in a first target area, behavior prompt information representing prompting the pedestrian to make a corresponding behavior; determining whether a deceleration condition matching the behavior prompt information is satisfied based on acquired behavior information of the pedestrian; and sending control information for reducing a moving speed of the autonomous vehicle, in response to determining that the deceleration condition is satisfied and determining that a speed of the autonomous vehicle is greater than a preset deceleration threshold. According to the embodiments, deceleration control of the autonomous vehicle is achieved based on the response of the pedestrian to the behavior prompt information.

Abstract: An application of a RyR2 protein or a recombinant RyR2 protein in preparing an anti-heart failure medicament is provided. The recombinant RyR2 protein is a naturally occurring RyR2 protein fragment or a mutant, such as a SPRY1 domain protein, a P1 domain protein, a SPRY2 domain protein, a SPRY3 domain protein, a Handle domain protein, an HD1 domain protein, an HD2 domain protein, a central domain protein, an EF-hand domain protein, a U-motif protein, a P2 domain protein, a P2 domain fragment protein-1, a P2 domain fragment protein-2 derived from a natural RyR2 protein or a P2 mutant derived from the natural RyR2 protein. The exogenous recombinant RyR2 protein is highly expressed in both normal small animal and diseased small animal models, so that the left ventricular ejection fraction of experimental animals is improved varying degrees compared with that of a control group.

Abstract: The application provides a vehicle driving guarantee method, an apparatus, a device, and a readable storage medium. The method includes: acquiring vehicle state information of a vehicle and current road environment information in real-time; sending the state information of the vehicle and the current road environment information to a monitoring terminal under a condition that the state information of the vehicle meets a preset driving guarantee condition, so that the monitoring terminal generates a control instruction according to a driving strategy after the driving strategy is determined according to the state information of the vehicle and the current road environment information by a monitoring user; and receiving the control instruction returned by the monitoring terminal, and controlling the vehicle to drive according to the control instruction.

Abstract: A remote control method for an autonomous vehicle includes: a central control device receives a remote control request message sent by a vehicle; detects a driving operation of a control person on the simulated cockpit; generates an instruction for simulating a driving operation according to the driving operation of a control person on the simulated cockpit, where the instruction for simulating a driving operation is used to simulate the driving operation of the control person on the simulated cockpit; and sends a remote control message to the vehicle. A remote control apparatus for an autonomous vehicle is also related.

Abstract: Provided are a method for preparing chimeric antigen receptor (CAR)-carrying exosomes derived from immune cells through isolation, and use of the CAR-carrying exosomes. The method includes: A) preparation of CAR expressing immune cells; B) antigen-specific activation of the CAR expressing immune cells; C) isolation of exosomes secreted by CAR expressing immune cells; and D) purification and enrichment of CAR exosomes. The immune cells in step A are T cells or NK cells; and the immune cells are derived from a patient or a healthy donor. CAR expressing immune cells are activated with specific antigens, and the resulting exosomes are further analyzed, isolated, purified and enriched to finally obtain CAR-carrying exosomes derived from immune cells. The exosomes can be used for treating cancer, severe infectious diseases, and other diseases.