Abstract: The present invention provides compositions, systems, kits, and methods for treating a subject, having a condition that causes a cytokine storm, by administering or providing a composition comprising a beta-secretase 1 (BACE1) inhibitor. In some embodiments, the composition reduces lung or other bodily inflammation in the subject (e.g., by reducing the cytokine storm caused by a virus). In certain embodiments, the subject is infected with a virus such as SARS-CoV-2, has received CAR-T cell immunotherapy, has an organ transplant, or has an autoimmune disease (e.g., arthritis).

Abstract: Provided herein are compositions, systems, kits, and methods for treating a subject with cancer by administering a BACE1 inhibitor, such as MK-8931. In particular embodiments, the subject is treated with radiation (e.g., low dose radiation) first, and then administered a BACE1 inhibitor within a certain time window (e.g., about 3 hours to 6 days after the radiation treatment).

Abstract: Provided herein are compositions, systems, kits, and methods for treating a subject with cancer by administering a BACE1 inhibitor, such as MK-8931. In particular embodiments, the subject is treated with radiation (e.g., low dose radiation) first, and then administered a BACE1 inhibitor within a certain time window (e.g., about 3 hours to 6 days after the radiation treatment).

Abstract: The invention encompasses a novel tumor marker TC1 which is present on tumor cells and absent on corresponding normal cells, nucleic acid encoding the tumor marker, and monoclonal antibodies to tumor marker TC1.

Abstract: The invention encompasses a novel tumor marker which is present on tumor cells and absent on corresponding normal cells, nucleic acid encoding the tumor marker, and a novel method of isolating DNA encoding the tumor marker or a gene which is differentially expressed in tissues.

Abstract: We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.