Abstract: According to the present invention, as processing apparatus drive starts, the operating state of software used to drive the processing apparatus is monitored in real time to diagnose whether or not an abnormality has occurred (S110). If it is judged through the diagnosis performed in S110 that no abnormality has occurred, the workpiece processing is allowed to continue uninterrupted and then a decision is made as to whether or not the workpiece processing has been completed (S130). If the processing has been completed, the processing apparatus is stopped (S140). If, on the other hand, it is judged through the diagnosis performed in S110 that an abnormality has occurred, a log of the diagnosis item with regard to which the abnormality has occurred is recorded (S120). The processing apparatus is then stopped (S140).

Abstract: According to the present invention, as processing apparatus drive starts, the operating state of software used to drive the processing apparatus is monitored in real time to diagnose whether or not an abnormality has occurred (S110). If it is judged through the diagnosis performed in S110 that no abnormality has occurred, the workpiece processing is allowed to continue uninterrupted and then a decision is made as to whether or not the workpiece processing has been completed (S130). If the processing has been completed, the processing apparatus is stopped (S140). If, on the other hand, it is judged through the diagnosis performed in S110 that an abnormality has occurred, a log of the diagnosis item with regard to which the abnormality has occurred is recorded (S120). The processing apparatus is then stopped (S140).

Abstract: A system in which a ligand is formed by the expression of a polypeptide that converts a ligand precursor into a ligand, and the ligand thus formed binds to a nuclear receptor to thereby induce the expression of a reporter gene located downstream of the target sequence is constructed. Searching a gene library using this system can isolate a gene encoding a polypeptide capable of converting a ligand precursor into a ligand. This system, which takes the advantage of the transcriptional regulatory function of a nuclear receptor, enables screening a ligand that binds to a nuclear receptor and to examine whether or not a test compound is a ligand that binds to the nuclear receptor, and also screening genes that encode polypeptides capable of converting an inactive form of a wide range of transcriptional regulatory factors into an active form.

Abstract: Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-? super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.

Abstract: A plasma processing apparatus having a focus ring, enables the efficiency of cooling of the focus ring to be greatly improved, while preventing an increase in cost thereof. The plasma processing apparatus is comprised of a susceptor which has an electrostatic chuck and the focus ring. A wafer W to be subjected to plasma processing is mounted on the electrostatic chuck. The focus ring has a dielectric material portion and a conductive material portion. The dielectric material portion forms a contact portion disposed in contact with the electrostatic chuck. The conductive material portion faces the electrostatic chuck with the dielectric material portion therebetween.

Abstract: The present invention relates to dextran whose boron content is reduced to a value less than 0.30 &mgr;g/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. Dextran of the present invention is obtained by treating a boron-containing dextran with a lower alcohol, and said dextran has such a characteristic that deposition is inhibited or the deposition rate is drastically reduced when using it in the form of a solution. Therefore, an isotonic sodium chloride solution of said dextran is suitably used as substitute plasma or external perfusate in an operation.

Abstract: According to the present invention, as processing apparatus drive starts, the operating state of software used to drive the processing apparatus is monitored in real time to diagnose whether or not an abnormality has occurred (S110). If it is judged through the diagnosis performed in S110 that no abnormality has occurred, the workpiece processing is allowed to continue uninterrupted and then a decision is made as to whether or not the workpiece processing has been completed (S130). If the processing has been completed, the processing apparatus is stopped (S140). If, on the other hand, it is judged through the diagnosis performed in S110 that an abnormality has occurred, a log of the diagnosis item with regard to which the abnormality has occurred is recorded (S120). The processing apparatus is then stopped (S140).

Abstract: A novel action mechanism wherein androgen receptor (AR) is activated by the interaction between cyclin E and the androgen receptor was revealed. This activation is resistant to existing anti-androgen agents and both androgen receptor ligand-dependent and independent activations were found to participate in this mechanism. Methods of screening for anti-androgen agents using cyclin E are also provided by the present invention. Based on the findings as described above, novel anti-androgen agents can be screened. These anti-androgen agents are expected to be efficacious also against pathological conditions that have become resistant to existing anti-androgen agents. Thus, the instant invention opens up new possibilities for treatment using anti-androgen agents that had their limitations until now.

Abstract: The present invention relates to dextran whose boron content is reduced to a value less than 0.30 &mgr;g/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. Dextran of the present invention is obtained by treating a boron-containing dextran with a lower alcohol, and said dextran has such a characteristic that deposition is inhibited or the deposition rate is drastically reduced when using it in the form of a solution. Therefore, an isotonic sodium chloride solution of said dextran is suitably used as substitute plasma or external perfusate in an operation.

Abstract: Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-&bgr; super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.

Abstract: Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-&bgr; super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAKI, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.

Abstract: A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.

Abstract: A process for producing a primary or secondary alcohol derivative of a phosopholipid which comprises reacting the phospholipid with a primary or secondary alcohol in the presence of phospholipase DM.

Abstract: A process for producing a sphingophospholipid derivative comprising reacting a sphingophospholipid with a specified compound having an alcoholic hydroxyl group selected from the group consisting of specified primary alcohol compounds, specified secondary alcohol compounds and specified saccharides or their phenol glycosides in the presence of phospholipase DM.

Abstract: A process for producing a saccharide derivative of a phospholipid, which comprises reacting a phospholipid with a monosaccharide having 5 to 7 carbon atoms, at least one primary alcohol group and at least three hydroxyl groups in total including the OH of the primary alcohol group or a disaccharide thereof, said saccharide being optionally substituted by a group selected from the class consisting of amino and acetylamino groups, or a phenol glycoside of said saccharide in the presence of phospholipase DM. The phospholipid-saccharide derivatives are useful as a liposome-forming substrate, or as an emulsifier for cosmetics, such as cream and lotion, fat solutions for transfusion and agricultural chemicals, such as pesticides and herbicides.

Abstract: A method for continuously crystallizing a solid component by continuously feeding a solution of the solid component in water or an organic solvent to a centrifugal film evaporator equipped with a scraper blade, which comprises feeding the solution from the top of the evaporator which comprises a heating section in the upper stream and a cooling section in the lower stream, forming a film of the solution on the wall of the evaporator, passing the film of the solution down into the heating section in order to evaporate the solvent, discharging the evaporated solvent from an upper outlet by feeding an inert gas or aspirating the solvent vapor in order to prevent the passage of evaporated solvent into the cooling section and contacting the cooling section of the evaporator with the concentrated solution whereby a crystallized solid or a slurry of solid particles is formed.This is a continuation, of application Ser. No. 443,519, filed Feb. 19, 1974 now abandoned.

Abstract: Nitrogen-containing heterocyclic compounds are prepared by cyclization of a compound having the formula: ##EQU1## or ##EQU2## wherein X represents a hydrogen atom or --CH.sub.2 CHR-Y; R represents a hydrogen atom or methyl atom; Y represents an --OH group or --NH.sub.2 group; and n represents the integers 0 or 1 - 4; with a zeolite catalyst having the formulaa(M.sub.2/n O). (Al.sub.2 O.sub.3) . m(SiO.sub.2)wherein M represents a cation selected from alkali metals, alkaline earth metals, zinc group elements, hydrogen and ammonium cations; n represents the valence of the cation; a is 1.0 .+-. 0.5 and m is 2 - 12.