Abstract: The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners.

Abstract: The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners.

Abstract: The present invention relates to a novel process for producing an N-formyl-neutral-amino acid and N-formylaspartic acid. The present invention also relates to a novel process for producing N-formyl-&agr;-L-aspartyl-L-phenylalanine methyl ester as a precursor of aspartame and aspartame, as well as a method of making a precursor of aspartame and aspartame by using the same.

Abstract: The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is a sweetener with high sweetening potency.

Abstract: The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is a sweetener with high sweetening potency.

Abstract: 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high potency of sweetness, can be easily and efficiently prepared on an industrial production from such an aldehyde derivative, via a reductive alkylation reaction with aspartame. Therefore, 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde is extremely excellent as an intermediate for the production of N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester.

Abstract: Dihydroisoxazole derivatives are conveniently converted to &ggr;-hydroxyamino acid derivatives which are important as various synthetic intermediates by a catalytic hydrogenation reaction. High-purity monatins which may be used as sweeteners or ingredients thereof can be obtained by subjecting a 5-indolylmethyl-4,5-dihydroisoxazole-3,5-dicarboxylic acid to catalytic hydrogenation.

Abstract: The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is a sweetener with high sweetening potency.

Abstract: N-[N-[3-(phenyl having various substituent group(s) on the benzene ring)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced on an industrial scale at a high yield by reductively alkylating aspartame with a 3-(phenyl having specified substituent group(s) on the benzene ring)-2-propenyl aldehyde and hydrogen in the presence of a catalyst and a base.

Abstract: 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high potency of sweetness, can be easily and efficiently prepared on an industrial production from such an aldehyde derivative, via a reductive alkylation reaction with aspartame. Therefore, 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde is extremely excellent as an intermediate for the production of N-[N-[3-(3-methyl-4-hydroxyphenyl)-3- methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester.

Abstract: Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at 25 to 80° C. under an absolute humidity of 0.203 kg/kg or less environment, thereby effecting crystal transition; and a method for preparing A-type crystals by controlling and maintaining the product temperature of D-type crystals of N-(3,3-dimethylbutyl)-APM at 25 to 80° C. under an absolute humidity of 0.0550 kg/kg or less environment, thereby effecting crystal transition. According to these crystal transition methods, highly stable crystals can be prepared stably and at a low cost.

Abstract: The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners.

Abstract: N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same.

Abstract: There is provided a thermoplastic polymer composition containing (i) 100 parts of a block copolymer comprising an aromatic vinyl block and a conjugated diene block, (ii) 5 to 200 parts of a polyurethane block copolymer having a thermoplastic polyurethane block, (iii) 10 to 300 parts of a thermoplastic polyurethane and (iv) 10 to 300 parts of a paraffin oil.

Abstract: A thermoplastic polymer composition is provided that includes 100 parts by weight of a block copolymer and/or its hydrogenate having polymer blocks of an aromatic vinyl compound and polymer blocks of a conjugated diene compound, and from 5 to 95 parts by weight of a block copolymer having polymer blocks of an aromatic vinyl compound and/or an olefinic compound and polymer blocks having a constitutional unit derived from a (meth) acrylic compound, a laminate containing a layer of the composition, and a hot-melt adhesive that includes the composition. Because it has good melt adhesiveness, the composition of the invention can firmly adhere in melt to various polar or non-polar materials. Using the composition, it is easy to produce laminates having a layer of the composition and a layer of some other material, through melt shaping or any other melt adhesion techniques.

Abstract: To provide a substrate material having characteristics suitable to a magnetic head for attaining high recording density. A substrate material for a magnetic head comprising a matrix phase of a carbide of one or more of Ti, W and Ta and a dispersion phase of an oxide of one or more of Al.sub.2 O.sub.3, CrO.sub.3, and ZrO.sub.2, in which the material comprises 60 to 95 vol % of the matrix phase of the carbide. Further, a single phase in which the ingredients of carbides as the matrix phase comprise (Ti.sub.j W.sub.m Ta.sub.n)C.sub.x is preferred. Further, oxygen and/or nitrogen may be solid-solubilized in the carbide MeC of the matrix phase wherein Me is one or more of Ti, W, and Ta.

Abstract: Substrate materials for magnetic heads consisting of 24-75 mol % of .alpha.-Al.sub.2 O.sub.3 and the remaining 76-25 mol % of TiC.sub.x O.sub.y N.sub.z containing a small amount of additives, that has a NaCl-type structure which retain known characteristics required on such materials and have controlled sizes of crystallites of Al.sub.2 O.sub.3 and TiC.sub.x O.sub.y N.sub.z, uniformly dispersed TiC.sub.x O.sub.y N.sub.z crystallites and, if any, additive elements, in which internal stress is relieved. The materials are intended for eliminating problems in IBE to form steps and thus for fabricating high-precision thin-film heads for high-density recording.

Abstract: Substrate materials for magnetic heads consisting of 24-75 mol % of .alpha.-Al.sub.2 O.sub.3 and the remaining 76-25 mol % of TiC.sub.X O.sub.Y N.sub.Z, or TiC.sub.X O.sub.Y N.sub.Z containing a small amount of additives, that has a NaCl-type structure which retain known characteristics required on such materials and have controlled sizes of crystallites of Al.sub.2 O.sub.3 and TiC.sub.X O.sub.Y N.sub.Z, uniformly dispersed TiC.sub.X O.sub.Y N.sub.Z crystallites and, if any, additive elements, in which internal stress is relieved. The materials are intended for eliminating problems in machining to form steps and thus for fabricating high-precision thin-film heads for high-density recording.