Abstract: [Problem] To provide, in order to manufacture cells to transplant into patients with corneal endothelial failure, a medium used to culture corneal endothelial cells obtained from human corneal tissue and grow said cells while maintaining the morphology thereof as corneal endothelial cells. [Solution] A medium containing a conditioned medium from mesenchymal stem cells; and a method in which said medium is used to culture corneal endothelial cells.

Abstract: The purpose of the present invention is to provide a refined-coal production method and a refined-coal production device, which exhibit excellent operability, and with which droplets accompanying steam generated when dehydrating moisture-containing coal is efficiently removed. This refined-coal production method is provided with: a step (A) in which a mixture including moisture-containing coal and oil is heated to dehydrate the coal; a step (B) in which droplets accompanying steam generated by performing dehydration are removed; and a step (C) in which steam, having had the droplets removed therefrom, is compressed to obtain high-temperature steam. The refined-coal production method is characterized in that, in step (B), the steam is sequentially passed through one or a plurality of mist separators, and removal of the droplets is performed while liquid is being sprayed onto a first mist separator through which the steam passes firstly.

Abstract: The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.

Abstract: Modified solid fuel manufacturing method and modified solid fuels manufactured using the manufacturing method. When solid fuels are manufactured by crushing low grade coal, mixing the crushed low grade coal with solvent oil to prepare a slurry, heating the slurry to at least the boiling point of water to evaporate moisture included in the slurry, separating the solvent oil from the slurry to produce charcoal dust and compression compacting said charcoal dust, by heating the slurry to at least the boiling point of water, the non-volatile components included in the low grade coal are extracted with the solvent oil, the outer surface of the low grade coal and the internal surfaces of the pores are coated with the extracted non-volatile components, and the content of heavy oil added from the outside will be less than 0.5 mass %, relative to the solid fuel after drying.

Abstract: A ophthalmologic method and apparatus for processing a captured image of a tear film lipid layer on a cornea of a patient's eye to be examined and for classifying types of dry eye of the patient's eye. The captured image of the tear film lipid layer is processed to measure a movement speed of the tear film lipid layer at the time of opening of the patient's eyelid. The captured image of the tear film lipid layer is further processed to measure a time until the tear film lipid layer is broken up after the patient's eyelid has been opened and a break up region is detected. The type of dry eye of the patient's eye is classified based on the two measurement results.

Abstract: Modified solid fuel manufacturing method and modified solid fuels manufactured using the manufacturing method. When solid fuels are manufactured by crushing low grade coal, mixing the crushed low grade coal with solvent oil to prepare a slurry, heating the slurry to at least the boiling point of water to evaporate moisture included in the slurry, separating the solvent oil from the slurry to produce charcoal dust and compression compacting said charcoal dust, by heating the slurry to at least the boiling point of water, the non-volatile components included in the low grade coal are extracted with the solvent oil, the outer surface of the low grade coal and the internal surfaces of the pores are coated with the extracted non-volatile components, and the content of heavy oil added from the outside will be less than 0.5 mass % relative to the solid fuel after drying.

Abstract: In an ophthalmic measuring method, a traceable marker in particulate form is administered to the lachrymal fluid of a subject's eye, and the lachrymal fluid is irradiated with illuminating light. Images of the illuminated lachrymal fluid are electronically captured respectively at different times. Two images from among the captured images are selected, with each of the two selected images displaying the traceable marker. A characteristic point of each of the two selected images is specified. A movement speed of the traceable marker is measured based on positions thereof in the two selected images and on a time difference from specifying the characteristic point of one of the two selected images to specifying the characteristic point of the other of the two selected images. The measured movement speed of the traceable marker is outputted as the movement speed of the lachrymal fluid of the subject's eye.

Abstract: According to one embodiment, a nonvolatile semiconductor memory device includes memory cell units, bit lines, word lines, and a controller. Each of the memory cell units includes a plurality of memory cells connected in series. Bit lines are connected respectively to the corresponding memory cell units. Each of the word lines is commonly connected to control gates of the corresponding memory cells of the memory cell units. The controller is configured to control a programming operation of data to the memory cells. The controller is configured to execute a first procedure including programming the data to the memory cell connected to the (4n?3)th (n being a natural number) bit line and the memory cell connected to the (4n?2)th bit line, and a second procedure including programming the data to the memory cell connected to the (4n?1)th bit line and the memory cell connected to the 4nth bit line.

Abstract: The present invention provides a method for the normalized culturing of corneal endothelial cells. More specifically, the present invention provides a culture-normalizing-agent of a corneal endothelial cell, comprising a fibrosis inhibitor. In detail, the present invention provides a culture-normalizing agent comprising a transforming growth factor (TGF) ? signal inhibitor. The present invention also provides a culture medium for culturing a corneal endothelial cell normally, which comprises the culture-normalizing agent according to the present invention and corneal endothelium culture components. The present invention also provides a method for culturing a corneal endothelial cell normally, comprising the step of culturing a corneal endothelial cell using the culture-normalizing agent according to the present invention or the culture medium according to the present invention.

Abstract: A method for separating solvent-containing water, which is generated in the process for producing an ashless coal, into a solvent and water readily without using any adsorbent or the like (a solvent separation method). The solvent separation method comprises: a solvent-containing water supply step of supplying the solvent-containing water into a pressure vessel for solvent separation purposes; and a temperature retention step of retaining the temperature of the solvent-containing water that has been supplied into the pressure vessel for solvent separation purposes at a predetermined temperature (e.g., 100 to 180 DEG C. inclusive). In the pressure vessel for solvent separation purposes, water in the liquid form moves downward and the solvent moves upward due to the difference between the density of water and the density of the solvent at the predetermined temperature. In this manner, the solvent-containing water can be separated into the solvent and water.

Abstract: The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.

Abstract: Provided is an ash-free coal production method without the need to once re-liquefy and form an ash-free coal. The ash-free coal production method includes an extraction step of mixing coal with a solvent to prepare a slurry and heating the slurry to extract a solvent-soluble coal component; a separation step of separating a solution containing the solvent-soluble coal component from the slurry obtained from the extraction step; an ash-free coal obtaining step of evaporatively separating the solvent from the solution separated in the separation step to obtain an ash-free coal. The ash-free coal obtaining step in the production method is performed so that the solvent is evaporatively separated from the solution to give a liquid ash-free coal, and the liquid ash-free coal is brought into contact with a solidifier (e.g., water) to solidify into a predetermined shape.

Abstract: Provided is an ash-free coal production method that can produce an ash-free coal efficiently with a higher solvent recovery rate. The ash-free coal production method includes an extraction step of mixing coal with a solvent to give a slurry and heating the slurry to extract a solvent-soluble coal component; a separation step of separating a solution containing the coal component from the slurry containing the extracted coal component; and an ash-free coal obtaining step of separating and recovering the solvent from the separated solution to give an ash-free coal. The ash-free coal obtaining step includes a pressure-reducing substep of reducing a pressure to a level lower than the solvent vapor pressure to evaporatively separate the solvent from the solution to thereby give a solid ash-free coal; and a heating substep of heating the solid ash-free coal to evaporatively separate a residual solvent from the ash-free coal.

Abstract: It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained.

Abstract: A method of upgrading coal which comprises: pulverizing low-grade coal; mixing the pulverized low-grade coal with an oil to form a slurry; heating the slurry to or above the boiling point of water to vaporize the water contained in the low-grade coal and dehydrate the coal; compressing a vapor mixture of the steam resulting from the slurry heating and that part of the oil which has vaporized simultaneously and thereby elevating the temperature and pressure of the vapor mixture; and supplying the vapor mixture increased in temperature and pressure by the compression and utilizing this vapor mixture as a high-temperature heat source to heat the slurry. In the method, the vapor mixture before being compressed is brought into contact with an oil in a liquid state.

Abstract: According to one embodiment, a nonvolatile semiconductor memory device includes a substrate, a tunneling insulating film, a floating gate, a leak suppression unit, an inter-gate insulating film, and a control gate. The substrate includes silicon. The tunneling insulating film is provided on the substrate. The floating gate is provided on the tunneling insulating film. The leak suppression unit is provided on the floating gate. The inter-gate insulating film is provided on the leak suppression unit. The control gate is provided on the inter-gate insulating film. The dielectric constant of the leak suppression unit is higher than a dielectric constant of the inter-gate insulating film.

Abstract: Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.

Abstract: Provided is a manufacturing method for a briquetted solid fuel that can reduce the briquetting cost while maintaining the strength of the briquetted product. A mixed oil that includes a heavy oil and a solvent oil, and a porous coal are mixed to obtain a slurry. The slurry is dewatered by heating to obtain a dewatered slurry. Solvent oil is separated from the dewatered slurry to obtain a cake, the cake is heated, and solvent oil is further separated from the cake to obtain a modified coal. Moisture is added to the modified coal to obtain a moist modified coal with a moisture content of 3 wt % to 10 wt %, and then the moist modified coal is briquetted under pressure.

Abstract: A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B).

Abstract: A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B).