Abstract: Provided herein are methods of treating certain cancers comprising administering to the subject in need there of an effective amount of a compound of Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Ra, and Rb are as defined herein.

Abstract: The present disclosure provides an automatic driving test method. The method includes: acquiring test configuration information input by a user; generating test cases according to the test configuration information, and allocating the test cases to corresponding test types, wherein test types comprise a virtual simulation test, a whole vehicle in-loop test, a closed site test, and an open road test; and under each test type, testing a to be tested vehicle based on the corresponding test cases to obtain test results corresponding to each of the test type, and the test results comprise a simulation test result, a whole vehicle in-loop test result, a closed road test result, and an open road test result. Thus obtaining rich comprehensive test evaluation results makes the test results for autonomous vehicles more accurate.

Abstract: An LED display screen, comprising: an LED array, consisting of multiple LED light-emitting units and used for emitting a light; an optical diffusion film, provided at a light exit side of the LED array; a matrix shading frame, comprising multiple hollow shading gratings, the hollow shading gratings corresponding one-to-one to the LED light-emitting units; and a substrate, used for supporting the LED array and the matrix shading frame, where the light emitted by the LED light-emitting units, after running through the hollow shading gratings, is diffused to a viewer side via the optical diffusion film, and the LED light-emitting units emit the light towards the hollow shading gratings.

Abstract: A head-up display screen, a head-up display assembly, and a vehicle are provided. The head-up display screen is attached to an inner side of an attachment surface of a windshield and configured to reflect image light emitted towards the windshield. The head-up display screen includes a functional layer, a reflective layer, and a protective layer that are sequentially arranged in a direction from the windshield to a driving position. The functional layer includes prism microstructures protruding from the inner side of the attachment surface of the windshield. The reflective layer is at least attached to lower inclined surfaces of the prism microstructures and is configured to reflect the image light towards the driving position. The protective layer covers the reflective layer and the functional layer.

Abstract: A medical image processing method, an X-ray diagnostic apparatus, and a method of generating a learned model includes receiving first X-ray image data, inputting the first X-ray image data to a trained model, outputting, from the trained model, an X-ray image having an image quality higher than an image quality of the first X-ray image data. The learned model was trained using contrastive learning using second X-ray image data as input data, third X-ray image data and fourth X-ray image data as label data, the third X-ray image data being negative label data having worse image quality than the second X-ray image data, and the fourth image data being positive label data having better image quality than the second X-ray image data.

Abstract: A light-shielding frame and an LED display device are provided and respectively has excellent light-shielding performance and optical display performance. The light-shielding frame includes a retaining wall and hollow grids; the retaining wall includes first and second retaining walls connected in a stacked manner along a light-emitting direction of the grids, and each grid includes first and second grid portions. The thickness of the first retaining wall decreases from one end thereof close to the second retaining wall to the other end thereof distant from the second retaining wall to form a first draft angle; the thickness of the second retaining wall decreases from one end thereof close to the first retaining wall to the other end thereof distant from the first retaining wall to form a second draft angle; the first retaining wall has the same thickness as the second retaining wall in the connection position thereof.

Abstract: Disclosed is an LED display screen, including an LED array including LED light emitting units and arranged on a substrate, a diffusion film arranged at a light-exiting side of the LED array, and a matrix light-shielding frame arranged between the LED array and the diffusion film. A hollow grid array including hollow grids is included. The hollow grids correspond one-to-one to the LED light emitting units and a projection of each hollow grid on the substrate surrounds a corresponding one of the plurality of LED light emitting units. Light emitted from the LED array can pass through a projection region of the matrix light-shielding frame on the diffusion film and exiting therefrom.

Abstract: Provided are a wavelength conversion apparatus, a light source system including the same, and a display device including the light source system. The wavelength conversion apparatus includes an angle deflection region and a wavelength conversion region for converting incident second light into excited light and then emitting same. The angle deflection region includes deflection units, each of which includes a light emergent face for emitting first light. A first included angle is formed between the light emergent face and a reference plane. First included angles between light emergent faces of at least two deflection units and the reference plane are not equal. The deflection units are located on a light path of the first light in a time sequence, so as to change an emergent angle of the first light in the time sequence, such that the first light is successively scanned at a preset position to form virtual pixels.

Abstract: Disclosed in the present application are a multi-shared directory tree-oriented control method and system. The method includes: setting a number of circular queues and a number of worker execution units in a Samba configuration file of a server according to a number of directories to be shared; running a Samba main process on the server; obtaining a data read-write test request from a client; and orienting request tasks of individual directories to individual worker execution units according to the data read-write test request by using a Server Message Block (SMB) message header data-based adaptive equalization control algorithm. The system includes an Input/Output (IO) execution unit, a plurality of worker execution units, a setting unit, a request obtaining unit, and a concurrency control unit. According to the present application, the data processing efficiency of a Samba server and the data processing efficiency of a client may be effectively improved.

Abstract: The present disclosure is drawn to the combination therapy of a C-C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

Abstract: Provided herein are methods of treating certain cancers comprising administering to the subject in need there of an effective amount of a compound of Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Ra, and Rb are as defined herein.

Abstract: a logic operation circuit, includes at least one differential logic operation circuit, the differential logic operation circuit includes a logic network module, a differential amplifier module, and a differential amplifier module. The logic network module includes a first logic network unit and a second logic network unit with functions complementarity to each other. A differential signal is generated based on input signals of the first logic network unit and the second logic network unit, the first logic network and the second logic network performs a predetermined logic function to output an operation result based on the input signals. The differential amplifier module, includes a first input terminal, a second input terminal, a first output terminal, a second output terminal, the first input terminal and the second input terminal are connected to an output of the first logic network and the second logic network respectively.

Abstract: A projection screen includes a substrate with a first substrate surface. The first substrate surface includes a first region and a second region adjacent to the first region. Multiple first wire grid bodies extending in a first direction are provided in the first region. Multiple second wire grid bodies extending in the first direction are provided in the second region. Each first wire grid body includes a first contact surface connected to the substrate and a first surface, and a first angle is formed therebetween. The first angles gradually decrease in a direction from the first region to the second region. Each second wire grid body includes a second contact surface connected to the substrate and a third surface, and a third angle is formed therebetween. The third angles gradually increase in a direction from the first region to the second region.

Abstract: The projection screen includes a reflective layer and a light-absorbing layer, where the reflective layer is configured to receive and reflect projection light, and the light-absorbing layer is arranged on the reflective layer; the light-absorbing layer includes a plurality of irregularly arranged light-absorbing members; and the light-absorbing members are configured to absorb at least a part of the projection light, so as to make a brightness of a projected image uniform.

Abstract: Provided herein are methods for treating a subject suffering from a cutaneous neutrophilic inflammatory disease comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein each variable position is as defined herein. In some embodiments, the cutaneous neutrophilic inflammatory disease is Hidradenitis suppurativa (HS).

Abstract: The present disclosure is drawn to the combination therapy of a C—C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

Abstract: Disclosed in the present application are a multi-shared directory tree-oriented control method and system. The method includes: setting a number of circular queues and a number of worker execution units in a Samba configuration file of a server according to a number of directories to be shared; running a Samba main process on the server; obtaining a data read-write test request from a client; and orienting request tasks of individual directories to individual worker execution units according to the data read-write test request by using a Server Message Block (SMB) message header data-based adaptive equalization control algorithm. The system includes an Input/Output (IO) execution unit, a plurality of worker execution units, a setting unit, a request obtaining unit, and a concurrency control unit. According to the present application, the data processing efficiency of a Samba server and the data processing efficiency of a client may be effectively improved.

Abstract: The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of cancer.

Abstract: The projection screen includes a reflective layer and a light-absorbing layer, where the reflective layer is configured to receive and reflect projection light, and the light-absorbing layer is arranged on the reflective layer; the light-absorbing layer includes a plurality of irregularly arranged light-absorbing members; and the light-absorbing members are configured to absorb at least a part of the projection light, so as to make a brightness of a projected image uniform.

Abstract: A head-up display screen, a head-up display assembly, and a vehicle are provided. The head-up display screen is attached to an inner side of an attachment surface of a windshield and configured to reflect image light emitted towards the windshield. The head-up display screen includes a functional layer, a reflective layer, and a protective layer that are sequentially arranged in a direction from the windshield to a driving position. The functional layer includes prism microstructures protruding from the inner side of the attachment surface of the windshield. The reflective layer is at least attached to lower inclined surfaces of the prism microstructures and is configured to reflect the image light towards the driving position. The protective layer covers the reflective layer and the functional layer.