Patents by Inventor Shiling Zhang

Shiling Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9677130
    Abstract: Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5? end and polyA sequences coupled to a tag at the 3? end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3? ends of these molecules.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: June 13, 2017
    Assignee: Institute For Systems Biology
    Inventors: Kai Wang, Shile Zhang, David Galas
  • Publication number: 20150337089
    Abstract: Provided is a composition comprising (a) one or more polyisocyanate, wherein said polyisocyanate has the structure of formula I: A-NCO??I and (b) one or more compound having the structure of formula II: A-L-Q-G??II wherein A in structure II is identical to A in structure I, L is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, Q is an organic group, and G is an anionic group, and wherein the ratio of the sum of the moles of isocyanate groups plus the moles of said L groups to the moles of said Q groups is 3:1 to 10:1. Also provided is an emulsion in which the particles comprise such a composition and further comprise (c) one or more water-insoluble compound that is different from said polyisocyanate (a).
    Type: Application
    Filed: October 28, 2013
    Publication date: November 26, 2015
    Inventors: Yongchun CHEN, Guoling HOU, Shiling ZHANG
  • Publication number: 20150274649
    Abstract: Provided is a composition comprising one or more compound having the structure of formula II: wherein A is a residue of a polyisocyanate, L is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, n is 5 to 25, m is 0 to 100, and Z is methyl or ethyl or propyl, and wherein the ratio of the sum of the moles of isocyanate groups plus the moles of said L groups to the moles of said Z groups is 2:1 to 30:1.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 1, 2015
    Inventors: Yongchun Chen, Shiling Zhang, Ling Yuan, Guoling Hou
  • Publication number: 20150265991
    Abstract: Provided is a composition comprising (a1) one or more compound that is a trimer of a diisocyanate that has structure A1-NCO; (b1) one or more compound having the structure A1-L1-(CH2CH2O)n—Z; (a2) one or more compound that is a trimer of a diisocyanate that has structure A2-NCO; and (b2) one or more compound having the structure A2-L2-Q-G; wherein A1 in structure II-1 is identical to A1 in structure I-1, L1 is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, n is 5 to 25, Z is an alkyl group, A2 in structure II-2 is identical to A2 in structure I-2, L2 is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, Q is an organic group, G is an anionic group, A1 and A2 may be identical or different, wherein wa1+wa2 is 0% to 90%, wherein wa1 is the weight percent of said compound (a1), based on the total solids weight of said composition, wherein wa2 is the weight percent of said compound (a2), based on the total solids weight of
    Type: Application
    Filed: October 28, 2013
    Publication date: September 24, 2015
    Inventors: Yongchun CHEN, Shiling ZHANG, Guoling HOU, Mai CHEN
  • Publication number: 20140287413
    Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Applicants: Battelle Memorial Institute, Institute for Systems Biology
    Inventors: David Galas, Richard Evan Gelinas, Clay Braden Marsh, Melissa Garnet Piper, Kai Wang, Shile Zhang
  • Patent number: 8748101
    Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: June 10, 2014
    Assignees: Battelle Memorial Institute, Institute for Systems Biology, The Ohio State University Research Foundation
    Inventors: David Galas, Richard Evan Gelinas, Clay Braden Marsh, Melissa Garnet Piper, Kai Wang, Shile Zhang
  • Publication number: 20140080711
    Abstract: Compositions for delivering an active ingredient include particles comprising an active ingredient (for example, 1-MCP complex powder) imbedded in a resin matrix, the particles being suspended in an oil medium. Methods for preparing such compositions include blending an active ingredient with a resin at a temperature higher than the melting point of the resin to provide a blend; dispersing the blend into an oil medium at a temperature higher than the melting point of the resin to provide a dispersion comprising dispersed particles in the oil medium; and consolidating the dispersed particles to provide consolidated particles comprising a solid matrix of the resin impregnated with the active ingredient. Methods of using such compositions include mixing the compositions with an aqueous medium to provide an emulsion or slurry and either contacting plants or plant parts with the emulsion or placing the emulsion near plants or plant parts.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 20, 2014
    Inventors: Shiling Zhang, Christian Guy Becker, Yunfei Yan, Yutian Shi, Yongchun Chen, Thomas H. Kalantar, Yueqian Zhen, Xiuhan Grace Yang, Christopher John Tucker
  • Publication number: 20140080712
    Abstract: The present invention relates to compositions, methods and materials for delivering a cyclopropene or other active ingredient to a plant. Provided are compositions comprising double encapsulated particles having a waxy coating and being imbedded in a resin matrix. Such double encapsulated particles are further coated with Pickering particles and suspended in an oil. The double encapsulated particles comprise a volatile compound (for example, 1-MCP complex powder) as an active ingredient. Also provided are methods for preparing such compositions and methods for using such compositions.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 20, 2014
    Inventors: Christine Lihong Lao, Shiling Zhang, Christian Guy Becker, Taylor Xiao Yi Pang, Tong Sun, Xiuhan Grace Yang
  • Publication number: 20140080710
    Abstract: Provided are compositions comprising a collection of coated particles, wherein the coated particles comprises an active ingredient dispersed in an resin matrix; and a coating comprising at least one hydrophobic compound. Also provided are methods for preparing compositions comprising: (a) blending an active ingredient (for example, 1-MCP complex powder) with resin at the temperature slightly over the melting point of the resin; (b) dispersing the blend into an oil medium containing hydrophobic particles by shearing and obtain an oil dispersion; and (c) consolidating the resin particles by cooling. Thus, the active ingredient (for example, 1-MCP complex powder) is imbedded in the resin matrix spheres, and the hydrophobic particles, which also serve as Pickering emulsifier to stabilize the matrix spheres, form a coating layer around the matrix spheres to provide protection against water. Thus, the sphere is composed of the “Pickering” particle and resin matrix, in which the active ingredient is imbedded.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 20, 2014
    Inventors: Shiling Zhang, Christian Guy Becker, Yunfei Yan, Yongchun Chen
  • Patent number: 8668489
    Abstract: An ignition system for a multi-burner heat exchanger assembly, a furnace, and a method using same are disclosed. The assembly may include a plurality of adjacent heat exchanger tubes, with a burner associated with each tube. All the burners may be lit with a single igniter and no source of secondary air. To do so, each of the burners may be provided so as to generate a swirling exit flow of combustion gases. One or more carryover tubes may also be connected between adjacent pairs of heat exchanger tubes or adjacent pairs of burners. The swirling flow generated by the burners causes hot combustion gases to move through the carryover tubes to thus carry the flame from one burner to the next. Not only can a single igniter be used, but a single flame sensor as well, while at the same time reducing nitrogen oxide emissions.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: March 11, 2014
    Assignee: Carrier Corporation
    Inventors: Louis Chiappetta, Scott A. Liljenberg, Meredith B. Colket, Shiling Zhang
  • Publication number: 20120283106
    Abstract: Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5? end and polyA sequences coupled to a tag at the 3? end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3? ends of these molecules.
    Type: Application
    Filed: February 15, 2012
    Publication date: November 8, 2012
    Applicant: Institute For Systems Biology
    Inventors: Kai WANG, Shile ZHANG, David GALAS
  • Publication number: 20120052452
    Abstract: An ignition system for a multi-burner heat exchanger assembly, a furnace, and a method using same are disclosed. The assembly may include a plurality of adjacent heat exchanger tubes, with a burner associated with each tube. All the burners may be lit with a single igniter and no source of secondary air. To do so, each of the burners may be provided so as to generate a swirling exit flow of combustion gases. One or more carryover tubes may also be connected between adjacent pairs of heat exchanger tubes or adjacent pairs of burners. The swirling flow generated by the burners causes hot combustion gases to move through the carryover tubes to thus carry the flame from one burner to the next. Not only can a single igniter be used, but a single flame sensor as well, while at the same time reducing nitrogen oxide emissions.
    Type: Application
    Filed: August 2, 2011
    Publication date: March 1, 2012
    Applicant: Carrier Corporation
    Inventors: Louis Chiappetta, Scott A. Liljenberg, Meredith B. Colket, Shiling Zhang
  • Publication number: 20100216139
    Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
    Type: Application
    Filed: November 10, 2009
    Publication date: August 26, 2010
    Applicants: BATTELLE MEMORIAL INSTITUTE, INSTITUTE FOR SYSTEMS BIOLOGY, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: David Galas, Richard Evan Gelinas, Clay Braden Marsh, Melissa Garnet Piper, Kai Wang, Shile Zhang