Patents by Inventor Shingo Matsumura

Shingo Matsumura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-piperidine compounds
    Patent number: 4336373
    Abstract: Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl ]phenoxy}propane.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Company, Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Quaternary ammonium substituted N-cinnamylpiperidines
    Patent number: 4336374
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Benzoguanamine derivatives, their production and pharmaceutical compositions containing the same
    Patent number: 4333933
    Abstract: Novel 2-amino-4-nicotinoylamino-6-halogenophenyl-s-triazines and acid addition salts thereof, possessing strong anti-inflammatory action when the phenyl group is mono- or di-halogen substituted. The compounds are formulated into pharmaceutical compositions in bulk or dosage form, and are administered to humans and animals having inflammatory conditions or disorders until the same are reduced or overcome. The novel compounds are prepared by various procedures such as reacting a benzoguanamine which is halogen-substituted with an active derivative of nicotinic acid, and recovering the 2-amino-4-nicotinoylamino-6-halogenophenyl-s-triazines thus formed.
    Type: Grant
    Filed: May 22, 1981
    Date of Patent: June 8, 1982
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshihisa Shibata
  • Carbamyl piperazine derivatives
    Patent number: 4269838
    Abstract: 4-(3-Aryloxy-2-hydroxypropyl)piperazines bearing a carbamyl, N-alkyl or N,N-dialkylcarbamyl group in the 1-position are .beta.-adrenergic blockers. A typical example is 1-carbamyl-4-(3-phenoxy-2-hydroxypropyl)piperazine.
    Type: Grant
    Filed: October 23, 1979
    Date of Patent: May 26, 1981
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Haruo Tanaka
  • 9H-Pyrido[3,4-b]indole derivatives
    Patent number: 4241064
    Abstract: 1-Substituted-9H-pyrido[3,4-b]indole derivatives, which are further optionally substituted in the 3- or 4-position, are inhibitors of xanthine-oxidase. A representative embodiment is 1-formyl-4-hydroxy-9H-pyrido[3,4-b]indole which can be prepared through the processing of Picrasma quassioides.
    Type: Grant
    Filed: October 10, 1979
    Date of Patent: December 23, 1980
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshitsugu Nomiyama, Tatsuhiko Kono, Masato Matsuda, Haruo Tanaka
  • Acyl derivatives of 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose
    Patent number: 4211866
    Abstract: Acylated derivatives of 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose have antitumor activity.
    Type: Grant
    Filed: October 3, 1978
    Date of Patent: July 8, 1980
    Assignees: Nippon Shinyaku Co., Ltd., Takara Shuzo Co., Ltd.
    Inventors: Shingo Matsumura, Masakuni Ozaki, Hisao Watanabe, Hiroyuki Kuroda, Teruya Nakamura, Akira Obayashi
  • Process for the preparation of 2-hydroxymethyl-3,4,5-trihydroxy piperidine
    Patent number: 4198481
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy piperidine, or moranoline, is prepared by culturing a moranoline-producing strain of microorganism of the genus Streptomyces in an appropriate culture medium and thereafter isolating moranoline from the culture medium.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: April 15, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Masahiro Yagi
  • Process for the preparation of phenopicolinic acid
    Patent number: 4009077
    Abstract: Phenopicolinic acid is produced by culturing a strain of Paecilomyces. The compound, which may be alternatively named as 5-(4-hydroxybenzyl)-2-pyridinecarboxylic acid, is a hypotensive agent.
    Type: Grant
    Filed: August 22, 1975
    Date of Patent: February 22, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Osamu Tanabe, Akira Obayashi, Teruya Nakamura, Osamu Suzuka, Masao Murayama, Shingo Matsumura