Abstract: Provided is a photocurable composition used for forming a resin layer of a concave-convex structure including a substrate and a resin layer provided on the substrate and having fine concavities and convexities formed on a surface thereof. A cured film of the photocurable composition has a surface free energy of 15 mJ/m2 to 40 mJ/m2 as measured based on the Kitazaki-Hata theory and a hardness of 0.05 GPa to 0.5 GPa as measured using a nanoindenter.

Abstract: Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.

Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Abstract: An article supplying apparatus includes a retention unit configured to retain an article, a robot hand configured to insert the article retained in the retention unit into a container, and a control unit configured to control operation of the robot hand. The robot hand has a holding portion for holding the article. The control unit executes holding control in which the article is held by the holding portion; and stand-by insertion control in which after the holding portion is temporarily disposed at a stand-by position different from a position immediately above an article insertion port in the container and set on a movement path from a start position of the holding through the holding control to the position immediately thereabove, the holding portion is moved to the position immediately thereabove, and the article is inserted into the container via the article insertion port.

Abstract: A power transmission device includes: a gear; a case receiving the gear; and a baffle plate positioned between the gear and the case; the baffle plate including a guide portion arranged to guide an oil scooped up by the gear, into between the baffle plate and the case, and the guide portion being disposed above an oil level within the case, the guide portion being adjacent to an axial side surface of the gear, the guide portion being positioned in the baffle plate on an upstream side in a rotation direction of the gear, and the guide portion including a first bent portion which is positioned on a tip end side, and which is bent in a direction from the case toward the gear.

Abstract: Provided is a system that enables additional information to be further posted in a state of being annexed to a posting image. The system includes: a posting-side annexed posting information registration unit that registers annexed posting information provided from a poster of the posting image in association with a position designated by the poster in the posting image; and a viewing-side annexed posting information registration unit that registers annexed posting information provided from a viewer of the posting image in association with a position designated by the viewer among the poster designation position and other positions. The poster can post annexed posting information by designating a position where the poster desires to get evaluation, and the viewer can post annexed posting information in association with the poster designation position, or can post the annexed posting information by designating a position where the viewer desires to perform evaluation or to make a comment.

Abstract: The present invention relates to a compound represented by general formula (I) (wherein, all symbols represent the same meanings as the symbols set forth in the specification), a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug of any of these. Since the compound has a Brk inhibitory activity, the compound is useful as a drug ingredient for the prevention and/or treatment of Brk-related diseases such as cancer, for example.

Abstract: Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.

Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Abstract: Provided is a photocurable composition used for forming a resin layer of a concave-convex structure including a substrate and a resin layer provided on the substrate and having fine concavities and convexities formed on a surface thereof. A cured film of the photocurable composition has a surface free energy of 15 mJ/m2 to 40 mJ/m2 as measured based on the Kitazaki-Hata theory and a hardness of 0.05 GPa to 0.5 GPa as measured using a nanoindenter.

Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Abstract: A repeater includes a reception unit, a permission signal generating unit that detects the state of the pulses of the signal, and generates a permission signal that permits a relay of the signal when the permission signal generating unit detects the pulses, and that inhibits the relay of the signal when the permission signal generating unit detects an end of the pulses, and a transmission unit. When detecting the end of the pulses, for the permission signal, the permission signal generating unit sets a pulse re-input monitoring period for determining whether or not the pulses of the signal are re-detected. When detecting the pulses of the signal during the pulse re-input monitoring period, the permission signal generating unit determines that the signal continues, and when not detecting the pulses of the signal, the permission signal generating units determines that the signal ends.

Abstract: Provided is a clutch friction plate and a clutch device configured so that stiction torque can be reduced and each of in gear, shift feeling, and neutral find can be smoothly performed. A clutch device (100) includes clutch friction plates (101). In the clutch friction plate (101), multiple small-piece-shaped friction members (103) are radially bonded to surfaces of a core bar (102) formed in a flat-plate annular shape through an oil groove (105). Each friction member (103) includes an outer side (104a) facing an outer edge portion of the core bar (102) and an inner side (104b) facing an inner edge portion of the core bar (102) and extending parallel to the outer side (104a), and is formed in a rectangular shape.

Abstract: The present invention relates to a Brk inhibitory compound represented by general formula (I) (wherein, all symbols represent the same meanings as the symbols set forth in the specification), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug of any of these.

Abstract: A repeater includes: a reception unit that receives a signal in the form of pulses; a permission signal generating unit that detects the state of the pulses of the signal, and generates a permission signal that permits a relay of the signal when the permission signal generating unit detects the pulses, and that inhibits the relay of the signal when the permission signal generating unit detects an end of the pulses; and a transmission unit that transmits the signal during a time period permitted by the permission signal. When detecting the end of the pulses, for the permission signal, the permission signal generating unit sets a pulse re-input monitoring period for determining whether or not pulses of the signal are re-detected. When detecting the pulses of the signal during the pulse re-input monitoring period, the permission signal generating unit determines that the signal continues, and when not detecting the pulses of the signal, the permission signal generating units determines that the signal ends.

Abstract: Provided is a flexographic printing plate having improved abrasion resistance in addition to the appropriate elasticity (softness) required from a flexographic printing plate. The present invention is a block copolymer for a photosensitive printing plate material, the block copolymer comprising at least two polymer blocks having an aromatic vinyl monomer as a main constituent; and at least one polymer block having a conjugated diene monomer as a main constituent, wherein the amount of the aromatic vinyl monomer introduced into the polymer block having a conjugated diene block as a main constituent is 25% to 50% by weight of the content of all aromatic vinyl monomers to be bonded in the block copolymer.

Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Abstract: An article supplying apparatus includes a retention unit configured to retain an article, a robot hand configured to insert the article retained in the retention unit into a container, and a control unit configured to control operation of the robot hand. The robot hand has a holding portion for holding the article. The control unit executes holding control in which the article is held by the holding portion; and stand-by insertion control in which after the holding portion is temporarily disposed at a stand-by position different from a position immediately above an article insertion port in the container and set on a movement path from a start position of the holding through the holding control to the position immediately thereabove, the holding portion is moved to the position immediately thereabove, and the article is inserted into the container via the article insertion port.

Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.

Abstract: A power transmission device includes: a gear; a case receiving the gear; and a baffle plate positioned between the gear and the case; the baffle plate including a guide portion arranged to guide an oil scooped up by the gear, into between the baffle plate and the case, and the guide portion being disposed above an oil level within the case, the guide portion being adjacent to an axial side surface of the gear, the guide portion being positioned in the baffle plate on an upstream side in a rotation direction of the gear, and the guide portion including a first bent portion which is positioned on a tip end side, and which is bent in a direction from the case toward the gear.