Abstract: The present invention provides a compound having p38 MAP kinase inhibitory activity. Because of having p38 MAP kinase inhibitory activity, the compounds represented by the formula (I): wherein each symbol is as defined in the description, salts thereof, N-oxides thereof, solvates thereof, or prodrugs thereof are useful in preventing and/or treating diseases that are supposedly caused or deteriorated by abnormal production of cytokines including inflammatory cytokines or chemokines, or by overresponse thereto, namely cytokine-mediated diseases such as inflammatory diseases, respiratory diseases, cardiovascular diseases and bone diseases.

Abstract: The present invention relates to a compound that has p38 MAP kinase inhibitory activity useful as drug medicine, represented by the general formula (I): wherein all the symbols are as defined in the description, or its salt, N-oxide or solvate, or a prodrug thereof. Further, there are provided a process for producing the same and usage thereof. The compound of the general formula (I) has a p38 MAP kinase inhibitory activity and is useful for the prevention and/or treatment of diseases in which an abnormal production of cytokine, such as inflammatory cytokine or chemokine, or an over-reaction thereto would be instrumental in the cause and aggravation of pathologic condition thereof, namely, cytokine-mediated diseases, for example, inflammatory diseases, respiratory diseases, circulatory diseases, central nervous diseases, etc.

Abstract: A wiring board (lead frame) has a configuration in which a high-frequency current suppression member formed of a conductive soft magnetic film having high magnetic permeability is provided in a near field (magnetic field dominant area) in a lead frame part (wiring part) which can be a radiation noise source, preferably, in the periphery of the lead frame part.

Abstract: The present invention relates to a compound represented by formula (I): (wherein all the symbols have the same meanings as defined in the above description) and a production method and use thereof. The compounds represented by formula (I), or its salt, N-oxide or solvate, or a prodrug thereof have p38 MAP kinase inhibitory activity, and are useful in the prevention and/or treatment of those diseases that are supposedly caused or deteriorated by abnormal production of cytokines including inflammatory cytokine or chemokine, or by over response thereto, namely cytokine-mediated diseases such as inflammatory diseases, respiratory diseases, cardiovascular disease, central nervous system diseases, and the like.

Abstract: The object of the present invention is to provide a hopper having a simplified structure that can prevent fragments of component parts generated by vibrations and bolts, nuts, etc., that have fallen out of place from intermixing with the articles in the weighing hoppers or on the conveyor of a combination weighing apparatus. A link mechanism for opening and closing a gate is arranged on a plate provided on one side of the box-like body of a pool hopper. A cover that covers the entire link mechanism is provided and the cover is configured such that it can be freely attached to and detached from the box-like body. The cover can be attached to and detached from the box-like body by engaging and disengaging an engaging member of the cover with and from a nut coupled to the box-like body.

Abstract: The object of the present invention is to provide a hopper having a simplified structure that can prevent fragments of component parts generated by vibrations and bolts, nuts, etc., that have fallen out of place from intermixing with the articles in the weighing hoppers or on the conveyor of a combination weighing apparatus. A link mechanism for opening and closing a gate is arranged on a plate provided on one side of the box-like body (20) of a pool hopper (7). A cover (25) that covers the entire link mechanism is provided and the cover (25) is configured such that it can be freely attached to and detached from the box-like body (20). An attachment/detachment mechanism (62) slides in the direction of arrows (O) and (P) inside a long hole (64) provided in a bulged part (63) of the cover main body (61).

Abstract: A piperidin-2-one derivative compound represented by formula (I): wherein all symbols are described in the specification, or a non-toxic salt thereof. The compound represented by formula (I) inhibits activation of p38MAP kinase, and is useful for prevention and/or treatment of various inflammatory diseases, rheumatoid arthritis, osteoarthritis, arthritis, osteoporosis, autoimmune diseases, infectious diseases, sepsis, cachexia, cerebral infarction, Alzheimer's disease, asthma, chronic pulmonary inflammatory diseases, reperfusion injury, thrombosis, glomerulonephritis, diabetes, graft versus host rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, multiple sclerosis, tumor growth and metastasis, multiple myeloma, plasma cell leukemia, Castleman's disease, atrial myxoma, psoriasis, dermatitis, gout, adult respiratory distress syndrome (ARDS), arteriosclerosis, post-percutaneous transluminal coronary angioplasty (PTCA) restenosis or pancreatitis.

Abstract: An allocating mechanism of a weighing apparatus that temporarily stores objects and allocates the objects to a plurality of hoppers disposed below is provided to reduce the amount of objects that remain without being allocated. The allocating mechanism 21 is included in the weighing apparatus. The allocating mechanism 21 is a mechanism that temporarily stores objects, and allocates the objects to hoppers 24 and 25 disposed below. The allocating mechanism 21 includes a tubular member 61, a bottom plate 62, a driving motor, and a controller. The bottom plate 62 can, together with the tubular member 61, form a storage space S, in which the objects are stored. The driving motor rotates the tubular member 61 and the bottom plate 62. The controller controls the driving motor to rotate the tubular member 61 and the bottom plate 62, such that the objects are dropped in one of the hoppers 24 and 25.

Abstract: An allocating mechanism of a weighing apparatus that temporarily stores objects and allocates the objects to a plurality of hoppers disposed below is provided to reduce the amount of objects that remain without being allocated. The allocating mechanism 21 is included in the weighing apparatus. The allocating mechanism 21 is a mechanism that temporarily stores objects, and allocates the objects to hoppers 24 and 25 disposed below. The allocating mechanism 21 includes a tubular member 61, a bottom plate 62, a driving motor, and a controller. The bottom plate 62 can, together with the tubular member 61, form a storage space S, in which the objects are stored. The driving motor rotates the tubular member 61 and the bottom plate 62. The controller controls the driving motor to rotate the tubular member 61 and the bottom plate 62, such that the objects are dropped in one of the hoppers 24 and 25.