Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: The objective of the present invention is to provide a novel ASMT expression promoter. Provided are an ASMT expression promoter comprising ectoine or a physiologically acceptable salt thereof as an active ingredient, and a melatonin synthesis promoter comprising ectoine or a physiologically acceptable salt thereof as an active ingredient, which promotes melatonin synthesis through the promotion of ASMT expression. Effects such as improvement of sleep disorder, improvement of cognitive function, improvement of mood disorder, enhancement of antioxidant activity, and enhancement of anti-inflammatory activity can be enhanced by promoting melatonin synthesis through the promotion of ASMT expression.

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1?-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Abstract: A method for promoting expression of a clock gene and/or a hyaluronic acid synthase gene in skin, comprising applying onto skin a composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative.

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: Provided is a novel drug capable of inhibiting excessive formation of melanin in skin and a skin whitening agent incorporated therewith. Phenylethyl cinnamate is incorporated as an active ingredient.

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: Provided is a novel drug capable of inhibiting excessive formation of melanin in skin and a skin whitening agent incorporated therewith. Phenylethyl cinnamate is incorporated as an active ingredient.

Abstract: The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1?-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Abstract: Disclosed here is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-?-ionol and 4-methoxystyrene. Also disclosed is a method for elevating skin temperature comprising administering to a subject in need thereof a composition comprising an effective amount of one or more compounds selected from the group consisting of dihydro-?-ionol, 4-methoxystyrene, clary sage extract, Japanese peppermint extract, juniper berry extract, and geraniol.

Abstract: A method for promoting expression of a clock gene and/or a hyaluronic acid synthase gene in skin, comprising applying onto skin a composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative.

Abstract: A rose-like fragrance composition including methyl epijasmonate, provided that a natural jasmine fragrance containing methyl epijasmonate is excluded. The rose-like fragrance composition can also include 2-isopropyl-4-methyl thiazole.

Abstract: The present invention provides substances that can be used in a broad range of applications and effectively regulate clock gene expression. Provided is a clock gene expression regulating agent comprising, as an active ingredient, one or more selected from the group consisting of caryophyllene oxide and compounds represented by the following structural formula: wherein X is CH3, NH2 or NHCH3.

Abstract: A rose-like fragrance composition including methyl epijasmonate, provided that a natural jasmine fragrance containing methyl epijasmonate is excluded. The rose-like fragrance composition can also include 2-isopropyl-4-methyl thiazole.

Abstract: The present invention provides substances that can be used in a broad range of applications and effectively regulate clock gene expression. Provided is a clock gene expression regulating agent comprising, as an active ingredient, one or more selected from the group consisting of caryophyllene oxide and compounds represented by the following structural formula: wherein X is CH3, NH2 or NHCH3.

Abstract: An object of the present invention is to provide a skin temperature elevating agent that can further effectively raise a skin temperature. Another object is to provide a cosmetic composition, a food and a sundry article having a skin temperature elevating effect. A skin temperature elevating agent of the present invention is selected from one or more selected from a group consisting of: an extract of Japanese peppermint; an extract of clary sage; dihydro-?-ionol; and geraniol, and thus it can raise a skin temperature of a cheek. The skin temperature elevating agent according to the present invention is also selected from one or more selected from a group consisting of: an extract of Japanese peppermint; an extract of juniper berry; and 4-methoxystyrene, and thus it can raise a skin temperature of a hand fingertip. Hence, the skin temperature elevating agent according to the present invention can further effectively raise a skin temperature.

Abstract: Disclosed are a sympathetic inhibitor allowing more effective inhibition of activity of a sympathetic nerve, as well as a cosmetic composition, a food, and a sundry article containing the same. Ethyl 4-methoxybenzoate is efficacious for quieting down the activity of the sympathetic nerve. The sympathetic inhibitor, the cosmetic composition, the food and the sundry article containing the same enable more effective inhibition of the activity of the sympathetic nerve.

Abstract: Provided is a fragrance composition having a natural rose aroma with freshness, sweetness, and softness, which is hardly reproduced by combining aroma components conventionally known as rose aromas. Also provided is a fragrance composition having excellent rose-like naturalness, freshness, and richness. More specifically, provided are: a fragrance composition, having added thereto 2-isopropyl-4-methylthiazole alone or in combination with rose oxide; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma.