Abstract: The present invention provides a substance which can modulate expression of a Period gene effectively and with a wide range of application. Provided is an expression modulator for the Period gene comprising, as an active ingredient, one or more selected from the group consisting of arnica extract, nuphar extract, black tea extract, Zanthoxylum extract, juniper oil, cedar oil, lavender oil, clove bud oil, cypress oil, rose oil, ylang-ylang oil, galbanum oil, petitgrain oil, pepper oil, thyme oil, basil oil, and beta-caryophyllene.

Abstract: The present invention provides a substance which can modulate expression of a Bmal gene effectively and with a wide range of application. Provided is an expression modulator for the Bmal gene comprising, as an active ingredient, one or more selected from the group consisting of hinoki cypress extract, chlorella extract, hop extract, Zanthoxylum extract, juniper oil, lavender oil, eucalyptus oil, olibanum, cypress oil, palmarosa oil, pineneedle oil, rose oil, ylang-ylang oil, elemi oil, petitgrain oil, pepper oil, thyme oil and chamomile oil.

Abstract: Provided is a fragrance composition having a natural rose aroma with freshness, sweetness, and softness, which is hardly reproduced by combining aroma components conventionally known as rose aromas. Also provided is a fragrance composition having excellent rose-like naturalness, freshness, and richness. More specifically, provided are: a fragrance composition, having added thereto 2-isopropyl-4-methylthiazole alone or in combination with rose oxide; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma.

Abstract: Skin blood circulation is improved, skin temperature is increased, or shoulder stiffness or sensitivity to cold is prevented or improved by using, as an active ingredient, at least one of the members selected from the group consisting of an Arabian jasmine (matsurika, jasmin sambac) extract, a damask rose (Rosa damascena) steam distillate, 3-methyloctano-4-lactone, and bornyl acetate.

Abstract: It is intended to provide a sedative effect-imparting agent that provides excellent sedative effect with good fragrance-releasing property, and is possible to provide the excellent sedative effect immediately. The sedative effect-imparting agent according to the present invention provides excellent sedative effect immediately, since it consists of dimethoxybenzene that provides excellent sedative effect with good fragrance-releasing property.

Abstract: Sympathetic nerve-stimulating fragrant compositions with weight-loss effects, characterized by containing one or more selected from among fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olibanum, or one or more from among limonene, pinene, myrcene and benzyl benzoate as the active ingredients in the oils, and preferably also containing caffeine.

Abstract: Sympathetic nerve-stimulating fragrant compositions with weight-loss effects, characterized by containing one or more selected from among fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olibanum, or one or more from among limonene, pinene, myrcene and benzyl benzoate as the active ingredients in the oils, and preferably also containing caffeine.

Abstract: Sympathetic nerve-stimulating fragrant compositions with weight-loss effects, characterized by containing one or more selected from among fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olibanum, or one or more from among limonene, pinene, myrcene and benzyl benzoate as the active ingredients in the oils, and preferably also containing caffeine.

Abstract: A natural flavor or fragrance can be easily and effectively produced by using a “unicellularized plant”, obtained by unicellularizing, without destroying, the cells of a plant usable as a starting material for a natural flavor or fragrance, as a material for the natural flavor or fragrance and further applying an enzymatic treatment or chemical treatment or continuously heating the same, to thereby remarkably shorten the aging period for producing the natural flavor or fragrance, or by homogenizing a plant usable as the starting material quickly after harvesting to thereby promote the aging.

Abstract: Escherichia coli characterized in that a capability thereof of forming acetate is at most one fifth that of wild type Escherichia coli, and a process for producing a useful substance by cultivating the Escherichia coli to a high density and recovering the substance

Abstract: A mutant strain having a glucose consumption rate is at most 1/4 that of wild type strains is provided. The mutant strain belongs to Escherichia, Bacillus, Pseudomonas, or Serratia; has a glucose consumption rate of at most one fourth that of the corresponding wild type strain, and the feedback repression by biotin is removed. Further, a process for producing biotins using this mutant strain is provided.