Abstract: Disclosed is a method for producing a fusion protein of human serum albumin and human growth hormone. The method comprises (a) a step of culturing a mammalian cell capable of producing the protein in a serum-free medium and causing the protein to be secreted into the culture fluid, (b) a step of collecting a culture supernatant by removing the mammalian cell from the culture fluid, and (c) a step of purifying the protein from the culture supernatant by using column chromatography using a material to which an antibody having an affinity for the protein is bound as a stationary phase, column chromatography using a material having an affinity for phosphate group as a stationary phase, cation exchange column chromatography, and size exclusion column chromatography.

Abstract: A nuclear fusion system comprises: a muon generation unit to generate negative muons including electron and positron accelerators for generating electron and positron beams; a gas supply unit to supply to circulate gaseous deuterium or gaseous deuterium-tritium mixture as raw material gas; a Laval nozzle to accelerate the raw material gas to supersonic velocity; and a shock wave cone connected to the Laval nozzle to introduce the raw material gas accelerated to supersonic velocity to generate an oblique shock wave, the raw material gas accelerated to supersonic velocity being introduced into the shock wave cone to generate the oblique shock wave, the oblique shock wave being decelerated to create a high-density gas target in an in-flight manner, the muons generated as a result of causing electrons and positrons to collide with each other being introduced into the high-density gas target thereby to cause a muon-catalyzed nuclear fusion reaction to occur.

Abstract: Used is a method for producing a thermal insulation sheet, including: composite-forming including impregnating a nonwoven fabric with a basic sol prepared by adding a carbonate ester to a water glass composition to form a hydrogel-nonwoven fabric composite; surface-modifying including mixing the composite with a silylating agent for surface modification; and drying including removing liquid contained in the composite through drying at a temperature lower than the critical temperature of the liquid under a pressure lower than the critical pressure of the liquid. Used is a thermal insulation sheet including an aerogel and a nonwoven fabric, where the thermal insulation sheet exhibits a compressibility of 40% or lower at 0.30 to 5.0 MPa.

Abstract: A torque load member has a detected surface which is configured to face a magnetostrictive torque sensor. The detected surface is a shot peened surface whose magnetic anisotropy directed in a specific direction has been reduced by performing shot peening thereto at an arc height value of 0.31 mmA or more.

Abstract: To provide a polyether polyol having a high degree of freedom in the design of a polyurethane foam, and capable of providing a polyol system solution excellent in storage stability. A polyether polyol having a polyoxyalkylene chain consisting of oxyalkylene units, and having a degree of unsaturation of at most 0.020 meq/g, a hydroxy value of from 1 to 80 mgKOH/g, a content of oxyethylene units of from 0 to 50 mass %, and a content of ultra-high molecular weight components which have molecular weights of from 12 to 46 times the number average molecular weight of at most 1,000 mass ppm. The number average molecular weight is a molecular weight as calculated as polystyrene measured by gel permeation chromatography (GPC) method, and the content of ultra-high molecular weight components is a value measured by high performance liquid chromatography (HPLC) method using a charged aerosol detector (CAD).

Abstract: An excessive torque releasing type clutch apparatus comprises an outer ring, an inner ring arranged radially inside and coaxially with the outer ring and rotatably relative to the outer ring, a torque transmitting portion capable of transmitting torque between the outer ring and the inner ring, and a restricting mechanism for restricting excessive torque from being input from an input torque transmitting member to a driving ring of the outer ring and the inner ring and restricting excessive inverse torque that is input to a driven ring of the outer ring and the inner ring from being input to the input torque transmitting member. Treatment steps for securing strength of constituent members of the clutch apparatus in manufacturing be simplified or omitted.

Abstract: A torque load member has a detected surface which is configured to face a magnetostrictive torque sensor. The detected surface is a shot peened surface whose magnetic anisotropy directed in a specific direction has been reduced by performing shot peening thereto at an arc height value of 0.31 mmA or more.

Abstract: An object of the present invention is to provide a pharmaceutical composition which has excellent stability, disintegratability, and absorbability, is easily prepared, and contains 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative. The present invention relates to a pharmaceutical composition containing 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and hydroxypropyl-Bi-cyclodextrin.

Abstract: An excessive torque releasing type clutch apparatus which can release torque when an excessive torque is input thereto, comprises an outer ring 3, an inner ring 5 arranged radially inside and in coaxial with the center axis of the outer ring 3 and rotatably relative to the outer ring 3, a torque transmitting portion that is capable of transmitting torque having the center axis as the center between the outer ring 3 and the inner ring 5, and a restricting mechanism for restricting a torque that exceeds a predetermined torque from being input from an input torque transmitting member to a driving ring of the outer ring 3 and the inner ring 5 and an inverse torque that is input to a driven ring of the outer ring 3 and the inner ring 5 and exceeds the predetermined torque from being input to the input torque transmitting member. Treatment step for securing strength of constituent members of the clutch apparatus in manufacturing process can be simplified or omitted.

Abstract: An object of the present invention is to provide a pharmaceutical composition which has excellent stability, disintegratability, and absorbability, is easily prepared, and contains 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative. The present invention relates to a pharmaceutical composition containing 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and hydroxypropyl-?-cyclodextrin.

Abstract: An object of the present invention is to provide a pharmaceutical composition which has excellent stability, disintegratability, and absorbability, is easily prepared, and contains 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative. The present invention relates to a pharmaceutical composition containing 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and hydroxypropyl-?-cyclodextrin.

Abstract: The flow path of a container valve communicates from a container attachment portion, to be attached to a fluid storage container, to an outlet, and is provided with a valve chamber, accommodating an open/close valve, in a middle part thereof. A portion of the flow path from an end of the container attachment portion to a bottom surface of the valve chamber is set as a primary flow path, and a portion of the flow path from an inner side surface of the valve chamber to an end of the outlet is set as a secondary flow path. In an outer circumferential portion of the bottom surface of the valve chamber, a discharge promotion groove is formed continuously with a portion corresponding to the lateral opening in a circumferential direction. A bottom surface of the secondary flow path is located below a bottom surface of the discharge promotion groove.

Abstract: Used is a method for producing a thermal insulation sheet, including: composite-forming including impregnating a nonwoven fabric with a basic sol prepared by adding a carbonate ester to a water glass composition to form a hydrogel-nonwoven fabric composite; surface-modifying including mixing the composite with a silylating agent for surface modification; and drying including removing liquid contained in the composite through drying at a temperature lower than the critical temperature of the liquid under a pressure lower than the critical pressure of the liquid. Used is a thermal insulation sheet including an aerogel and a nonwoven fabric, where the thermal insulation sheet exhibits a compressibility of 40% or lower at 0.30 to 5.0 MPa.

Abstract: Used is a method for producing a thermal insulation sheet, including: composite-forming including impregnating a nonwoven fabric with a basic sol prepared by adding a carbonate ester to a water glass composition to form a hydrogel-nonwoven fabric composite; surface-modifying including mixing the composite with a silylating agent for surface modification; and drying including removing liquid contained in the composite through drying at a temperature lower than the critical temperature of the liquid under a pressure lower than the critical pressure of the liquid. Used is a thermal insulation sheet including an aerogel and a nonwoven fabric, where the thermal insulation sheet exhibits a compressibility of 40% or lower at 0.30 to 5.0 MPa.

Abstract: The side airbag device includes an inflator and a side airbag that is stored in a folded state in a side portion of a seatback of a vehicle seat and is inflatable and deployable in a space between a vehicle sidewall and a side portion of an occupant. The side airbag includes an outer bag and an inner bag. The inner bag houses the inflator and is disposed at a rear portion of the outer bag along an extending direction of the seatback. The outer bag is provided with a vent hole configured to communicate with an outside. The inner bag is provided with a gas circulating hole configured to communicate with the outer bag. The gas circulating hole is disposed at a position to be blocked by the outer bag when the side airbag in an inflated and deployed state is pressed between the occupant and the vehicle sidewall.

Abstract: To provide a polyether polyol having a high degree of freedom in the design of a polyurethane foam, and capable of providing a polyol system solution excellent in storage stability. A polyether polyol having a polyoxyalkylene chain consisting of oxyalkylene units, and having a degree of unsaturation of at most 0.020 meq/g, a hydroxy value of from 1 to 80 mgKOH/g, a content of oxyethylene units of from 0 to 50 mass %, and a content of ultra-high molecular weight components which have molecular weights of from 12 to 46 times the number average molecular weight of at most 1,000 mass ppm. The number average molecular weight is a molecular weight as calculated as polystyrene measured by gel permeation chromatography (GPC) method, and the content of ultra-high molecular weight components is a value measured by high performance liquid chromatography (HPLC) method using a charged aerosol detector (CAD).

Abstract: A heat-insulation sheet includes a first silica xerogel layer, a second silica xerogel layer, and a composite layer. The first silica xerogel layer includes a first silica xerogel, and the second silica xerogel layer includes a second silica xerogel. The composite layer is located between the first silica xerogel layer and the second silica xerogel layer, and includes at least one type of unwoven fabric fibers, and a third silica xerogel. The third silica xerogel is located in a spatial volume of the unwoven fabric fibers.

Abstract: A heat-insulation sheet includes a first silica xerogel layer, a second silica xerogel layer, and a composite layer. The first silica xerogel layer includes a first silica xerogel, and the second silica xerogel layer includes a second silica xerogel. The composite layer is located between the first silica xerogel layer and the second silica xerogel layer, and includes at least one type of unwoven fabric fibers, and a third silica xerogel. The third silica xerogel is located in a spatial volume of the unwoven fabric fibers.

Abstract: An object of the present invention is to provide a pharmaceutical composition which has excellent stability, disintegratability, and absorbability, is easily prepared, and contains 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and a cyclodextrin derivative. The present invention relates to a pharmaceutical composition containing 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof and hydroxypropyl-?-cyclodextrin.

Abstract: A heat-insulation sheet includes a first silica xerogel layer, a second silica xerogel layer, and a composite layer. The first silica xerogel layer includes a first silica xerogel, and the second silica xerogel layer includes a second silica xerogel. The composite layer is located between the first silica xerogel layer and the second silica xerogel layer, and includes at least one type of unwoven fabric fibers, and a third silica xerogel. The third silica xerogel is located in a spatial volume of the unwoven fabric fibers.