Abstract: A method for treating a specimen in soluble GPC3 immunoassay, the method including mixing a soluble GPC3-containing specimen with a reducing agent. A soluble GPC3 immunoassay method including the following (a) and (b): (a) mixing a soluble GPC3-containing specimen with a reducing agent; and (b) measuring the amount of soluble GPC3 in the mixture obtained in (a) using one or more kinds of antibodies against soluble GPC3. A soluble GPC3 immunoassay reagent including the following (a) and (b): (a) a reducing agent; and (b) one or more kinds of antibodies against soluble GPC3.

Abstract: There is provided an air cleaner configured to be disposed behind an engine and inside a vehicle body frame. The air cleaner includes: an air cleaner case in which an intake chamber is formed; an air filter that divides the intake chamber into a dirty side and a clean side; an inlet tube configured to take in air from a vehicle rear side to the dirty side; and an outlet tube configured to send air from the clean side to the engine. The inlet tube and the outlet tube are attached to an upper side of the air cleaner case, and an expansion portion is formed on a lower side of the air cleaner case, the expansion portion being formed by expanding the clean side further downward than the dirty side.

Abstract: A measurement method and a measurement reagent for cardiac troponin which enable accurate measurement of the amount of cardiac troponin contained in a sample irrespective of the type of the sample and the presence or absence of other components are disclosed. The measurement method for cardiac troponin, wherein cardiac troponin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of cardiac troponin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

Abstract: A measurement method and a measurement reagent for thyroglobulin, which enable measurement of a more accurate amount of thyroglobulin by a single test without being influenced by interference of anti-thyroglobulin antibody, are disclosed. The measurement method for thyroglobulin, wherein thyroglobulin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of thyroglobulin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

Abstract: A measurement method including: measuring a fragment containing a human type IV collagen 7S domain in a sample by sandwich immunoassay, using a capture antibody in which a first monoclonal antibody capable of binding specifically to the human type IV collagen 7S domain is immobilized on a carrier and a labeled antibody in which a second monoclonal antibody capable of binding specifically to the human type IV collagen 7S domain binds to a labeling substance.

Abstract: A method for producing a shield wire includes: disposing the first terminal at an opening end portion of the shield body in a state where the covered wire and the shield body are inserted into the first terminal; folding the opening end portion of the shield body to an outer side and disposing the second terminal to sandwich the folded opening end portion; and press-deforming the first terminal and the second terminal into a clamping shape. A mold surface of the mold has a protruding portion protruding toward the axis, and a protruding end surface of the protruding portion has a radius of curvature smaller than a radius of an outer peripheral surface of the second terminal before clamping and larger than a radius of an outer peripheral surface of the covered wire before clamping.

Abstract: There is provided a method for producing a wet friction plate that can improve the retention property of lubricating oils in a fine groove formed by laser light. In a method for producing a wet friction plate (200), a friction material (210) is produced by sheet making processing in a first step. Thereafter, in a second step, a fine groove (211) is formed on the friction material (210). The friction material (210) is produced such that thermosetting resin therein is in a semi-cured state. The cross-sectional shape of the fine groove (211) is formed into a V shape by laser light. Subsequently, in a third step, the friction material (210) is disposed on a core metal (201) via an adhesive agent including thermosetting resin. Subsequently, in a fourth step, the friction material (210) is pressed while heated to crush the fine groove (211). In this manner, unevenness is formed on an intra-groove surface (212), and the thermosetting resin is completely cured.

Abstract: Provided are a method for manufacturing a wet friction plate, whereby efficiency of the work of forming a fine groove on a friction material can be improved, the wet friction plate, and a wet multiple-plate clutch device having the wet friction plate. In the method for manufacturing a wet friction plate 200, a core metal 201 and a friction material 210 are prepared, a resin layer 203 is formed on the core metal, the friction material is attached onto the resin layer, and a fine groove 211 is formed in the friction material. Specifically, irradiation of a laser beam L is started on an exposed portion 205 of the core metal. A laser head 301 is displaced in an annular shape while continuously emitting the laser beam. Thus, annular fine grooves 204 and 211 are formed in the exposed portion of the core metal and the friction material.

Abstract: There is provided an air cleaner configured to be disposed inside a vehicle body frame, the air cleaner including: an air cleaner case in which an intake chamber is formed; an air filter disposed in the intake chamber; an inlet tube configured to take in air to the intake chamber; and an outlet tube configured to send out the air from the intake chamber. The inlet tube extends in a front-rear direction. The inlet tube has a bottom wall curved downward in a side view to form a concave curved portion below a discharge port of the inlet tube. The concave curved portion is formed with a drain hole.

Abstract: There is provided an air cleaner configured to be disposed behind an engine and inside a vehicle body frame. The air cleaner includes: an air cleaner case in which an intake chamber is formed; an air filter that divides the intake chamber into a dirty side and a clean side; an inlet tube configured to take in air from a vehicle rear side to the dirty side; and an outlet tube configured to send air from the clean side to the engine. The inlet tube and the outlet tube are attached to an upper side of the air cleaner case, and an expansion portion is formed on a lower side of the air cleaner case, the expansion portion being formed by expanding the clean side further downward than the dirty side.

Abstract: The present invention provides a method of immunologically detecting SARS-CoV-2, the method comprising detecting a SARS-CoV-2 N protein in a specimen taken from a subject by using the following antibodies (1) and (2): (1) a first antibody to a first epitope in a 306th to 339th amino acid region in the SARS-CoV-2 N protein, and (2) a second antibody to a second epitope in a 365th to 419th amino acid region in the SARS-CoV-2 N protein.

Abstract: Disclosed is a novel method showing a higher detection sensitivity for hepatitis B virus genotype D than those of known methods. A method of immunoassay of hepatitis B virus core-related antigen uses, as an antibody to be used for the immunoassay, a monoclonal antibody that specifically binds to at least one kind of core-related antigen of hepatitis B virus genotype D, or an antigen-binding fragment thereof, wherein an epitope of the monoclonal antibody or the antigen-binding fragment thereof is a region included in the amino acid sequence from position 31 to 48 of SEQ ID NO:3.

Abstract: A lectin-binding substance measurement method is a method for measuring a lectin-binding substance in a sample, and includes: a capturing step of bringing a capture carrier including a water-insoluble carrier and a molecule immobilized on the water-insoluble carrier, the molecule being a molecule capable of capturing a lectin-binding substance, into contact with the sample to cause the capture carrier to capture the lectin-binding substance; a washing step of removing contaminants unbound to the capture carrier; a releasing step of releasing the lectin-binding substance from the capture carrier to obtain a prepared sample; and a measuring step of measuring the lectin-binding substance in the prepared sample by using a lectin.

Abstract: A lectin-binding substance measurement method is a method for measuring a lectin-binding substance in a sample, and includes a measuring step of bringing a blocked labeled lectin including a water-soluble carrier made of a first water-soluble polymer and a labeling substance and a lectin immobilized on the water-soluble carrier into contact with the sample.

Abstract: Disclosed is a highly sensitive assay method and assay kit for HBsAg, which do not require treatment with a strong acid or alkali in the sample pretreatment, and which is less susceptible to influences by the autoantibodies. The assay method for hepatitis B virus s antigen in a sample separated from a living body includes: a pretreatment step of mixing a sample with a pretreatment reagent containing a reducing agent, to reduce hepatitis B virus s antigen; and an immunoassay step of subjecting the pretreated sample to an immunoassay of hepatitis B virus s antigen using at least one antibody or antigen-binding fragment thereof capable of antigen-antibody reaction with a reduced peptide composed of the amino acids at positions 98 to 179 of hepatitis B virus s antigen.

Abstract: Disclosed are a measurement method and a measurement reagent for thyroglobulin, which measurement method and measurement reagent enable more accurate measurement of the thyroglobulin level by a single test without being influenced by interference of anti-thyroglobulin antibody, and which measurement method and measurement reagent allow use of even an antibody less resistant to an acidifier and/or a surfactant in an immunoassay. A method of measuring, by an immunoassay, thyroglobulin in a sample separated from a living body includes a pretreatment step of mixing the sample separated from the living body with a pretreatment liquid containing an alkaline substance.

Abstract: A method for producing a shield wire includes: disposing the first terminal at an opening end portion of the shield body in a state where the covered wire and the shield body are inserted into the first terminal; folding the opening end portion of the shield body to an outer side and disposing the second terminal to sandwich the folded opening end portion; and press-deforming the first terminal and the second terminal into a clamping shape. A mold surface of the mold has a protruding portion protruding toward the axis, and a protruding end surface of the protruding portion has a radius of curvature smaller than a radius of an outer peripheral surface of the second terminal before clamping and larger than a radius of an outer peripheral surface of the covered wire before clamping.

Abstract: A connector housing includes a housing main body, a seal element between an electric wire section of a terminal-equipped electric wire and the housing main body, and a rear holder configured to be attached to the housing main body so as to close the rear side opening and has a passage hole for the electric wire section and a plurality of protrusions, the passage hole having a larger opening area than a radial cross section area of the electric wire section, wherein the protrusions protrude from an inner circumferential surface of the passage hole with a protrusion length in such a way that one of vertices is positioned in each of three regions of the passage hole which are obtained by dividing it equally in a plan view on the passage hole, the protrusion length being adapted to an inner circumference position of a sealing through hole.

Abstract: Provided are a method for manufacturing a wet friction plate, whereby efficiency of the work of forming a fine groove on a friction material can be improved, the wet friction plate, and a wet multiple-plate clutch device having the wet friction plate. In the method for manufacturing a wet friction plate 200, a core metal 201 and a friction material 210 are prepared in a first step. Thereafter, a resin layer 203 is formed on the core metal 201 in a second step. The resin layer 203 is formed on each of entire two plate surfaces of the core metal 201. Subsequently, the friction material 210 is attached onto the resin layer 203 of the core metal 201 in a third step. Subsequently, a fine groove 211 is formed in the friction material 210 in a fourth step. Specifically, irradiation of a laser beam L is started on an exposed portion 205 of the core metal 201. A laser head 301 is displaced in an annular shape while continuously emitting the laser beam L.

Abstract: A power circuit shut off device includes a housing and a switch portion provided in the housing, and an operating member configured to turn on or turns off the switch portion. The switch portion includes a pair of terminals arranged along a bottom face of the housing, an electric conductive member having contact point portions and that is elastically urged toward the pair of terminals, and an insulating movable member configured to move along a direction in which the pair of terminals are arranged. The pair of terminals are brought into electric conductive to each other when the pair of terminals contact the contact point portions respectively. The insulating movable member is moved between a shut-off position and a conductive position by an operation on the operating member.