Abstract: Pseudoephedrine hydrochloride extended-release tablets including a sustained release hydroxypropylmethylcellulose matrix and a microcrystalline cellulose disintegrant formed by a dry mixed, direct compression method.

Abstract: A medicament includes a caplet having a peripheral land which is inserted into mating capsule shell halves each with internally formed recesses defining external peripheral lands which align when the shell halves are fitted over the caplet. In one embodiment of the invention, the internal diameter of the capsule shells is selected such that the caplet will fit within the capsule cell regardless of its orientation, while in another embodiment the caplet land mates with the internal recesses of the capsule shells. In a preferred embodiment of the invention, the capsule shells have different lengths and diameters such that one overlaps the other and can be sealed.

Abstract: An orally administrable sustained-release dosage form includes particles of an active pharmaceutical ingredient which is coated with a polymeric material that is water-insoluble, but water-permeable and water-swellable, so that the sustained-release dosage form provides controlled release which is independent of certain variable physiological factors such as pH. In accordance with one aspect of the invention, the active pharmaceutical ingredient is acetaminophen and the coated acetaminophen particles are combined with uncoated acetaminophen particles to provide a combination immediate-release/sustained-release dosage form.

Abstract: An improved castable refractory composition having excellent resistance to attack from slag can be efficiently transported to a destination, such as a mold, using a pump. The castable refractory composition includes about 36-92% by weight silicon carbide, about 8-20% by weight of a colloidal silica binder, and a balance substantially of other refractory materials which can include alumina, microsilica, graphite, and a setting agent. The composition of the invention can be used alone or in addition to a conventional refractory casting material to form a refractory lining. When used together, the conventional refractory composition is used to construct a lower layer in the refractory lining, and the composition of the invention is used to construct an upper refractory layer above the lower layer.